Our service for diagnosing primary ciliary dyskinesia (PCD) is discontinued

Effective immediately, University of Florida Health Pathology Laboratories' service for diagnosing primary ciliary dyskinesia (PCD) is discontinued. The modern, state-of-the-art method for diagnosing or excluding this condition involves a panel of several different diagnostic methods, including nasal nitric oxide measurements, functional ciliary beat frequency by video imaging, immunofluorescence testing for specific ciliary proteins, electron microscopy (EM)  and gene sequencing. No single diagnostic method is sufficient for the diagnosis of all cases of PCD, and a combination of methods is usually required. At this time, we only offer the EM component of this comprehensive analysis. Because of this, please do not send patient specimens for this analysis to our laboratories, as our service for excluding PCD by EM only would be insufficient by best-practice diagnostic standards and, therefore, not optimal for quality patient care.

To help our clients provide their PCD-suspected patients with the best possible standard of care, we recommend sending their specimens to any of the participants of the Genetic Disorders of Mucociliary Clearance Consortium, a group of 10 government-subsidized medical institutions that focus on diagnosing ciliary conditions. These are the best diagnostic facilities in North America for interpreting ciliary specimens, and they can diagnose patients with suspected PCD with far greater accuracy than our laboratories at this time.

INSTITUTION LOCATION
The Children's Hospital Colorado Denver, Colorado
Seattle Children’s Hospital Seattle, Washington
The Hospital for Sick Children Toronto, Ontario, Canada
Indiana Universty School of Medicine, Department of Pediatrics Indianapolis, Indiana
McGill University Montréal, Québec, Canada
National Heart, Lung and Blood Institute Bethesda, Maryland
National Jewish Health Denver, Colorado
Stanford University Medical Center Palo Alto, California
University of North Carolina at Chapel Hill Chapel Hill, North Carolina
Washington University St. Louis, Missouri


If you have any questions about this change, please call our Client Services Department toll-free at 888.372.LABS (5227) or locally at 352.265.9900.

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