Next-Generation Sequencing

Next-generation sequencing (NGS) is a massively parallel, high-throughput DNA sequencing technique that is changing the way laboratory tumor molecular profiling is performed. Cancer-causing mutations often cluster in hotspots, where tumors from different patients harbor the same recurrent mutation. NGS allows for the testing a large number of clinically actionable hotspots simultaneously, allowing for the selection of the appropriate treatment for each patient.

Tumor Mutation Analysis by Next-Generation Sequencing (NGS)

Mutation hotspots in the following genes are evaluated with this panel:
  • ABL1
  • AKT1
  • ALK
  • BRAF
  • CTNNB1
  • EGFR
  • ERBB2/HER2
  • EZH2
  • FBXW7
  • FGFR1
  • FGFR2
  • FLT3
  • GNA11
  • GNAQ
  • HRAS
  • IDH1
  • IDH2
  • JAK2
  • KIT
  • KRAS
  • MET
  • MPL
  • NOTCH1
  • NPM1
  • NRAS
  • PDGFRA
  • PIK3CA
  • PTEN
  • PTPN11
  • RET
  • SMAD4
  • SMO
  • TP53
Complete NGS targeted gene list
Updated: March 30, 2016
Next-Generation Sequencing