Lijun Yang

Lijun Yang,

PROFESSOR

Department: MD-PATHOLOGY
Business Phone: (352) 265-0071
Business Email: yanglj@pathology.ufl.edu

Teaching Profile

Courses Taught
2011-2018,2020-2023
DEN6350 General Pathology
2018
GMS7979 Advanced Research

Board Certifications

  • Lijun Yang
    Hematopathology
  • Lijun Yang
    Clinical Pathology
  • Lijun Yang
    Anatomic Pathology

Clinical Profile

Specialties
  • Pathology, Immunology and Laboratory Medicine

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-0522-3292

Publications

2023
Expression and secretion of glycosylated barley oxalate oxidase in Pichia pastoris.
PloS one. 18(5) [DOI] 10.1371/journal.pone.0285556. [PMID] 37167324.
2021
Classical Hodgkin Lymphoma Presenting as a Sigmoid Mass.
Gastroenterology research. 14(3):204-208 [DOI] 10.14740/gr1409. [PMID] 34267838.
2021
GLP-1 Induces the Expression of FNDC5 Derivatives That Execute Lipolytic Actions.
Frontiers in cell and developmental biology. 9 [DOI] 10.3389/fcell.2021.777026. [PMID] 34869379.
2020
Recent Updates of Irisin’s Anti-Obesity Research
Journal of Diabetes & Metabolism. 11(4) [DOI] 10.35248/2155-6156.20.11.843.
2019
Effects of irisin on the differentiation and browning of human visceral white adipocytes.
American journal of translational research. 11(12):7410-7421 [PMID] 31934288.
2018
Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.
The American journal of surgical pathology. 42(3):293-305 [DOI] 10.1097/PAS.0000000000000985. [PMID] 29194092.
2018
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00135. [PMID] 29456535.
2018
Primary Gastric EBV-positive Diffuse Large B Cell Lymphoma (DLBCL) of the Elderly with Plasmablastic Differentiation.
In vivo (Athens, Greece). 32(2):413-417 [PMID] 29475930.
2017
Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity.
Proceedings of the National Academy of Sciences of the United States of America. 114(34):8980-8985 [DOI] 10.1073/pnas.1706894114. [PMID] 28784797.
2017
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 69(6):1280-1293 [DOI] 10.1002/art.40077. [PMID] 28217966.
2016
“Lupoid hepatitis” in SLE patients and mice with experimental lupus.
Clinical immunology (Orlando, Fla.). 172:65-71 [DOI] 10.1016/j.clim.2016.07.007. [PMID] 27430519.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.). 68(12):2917-2928 [DOI] 10.1002/art.39781. [PMID] 27274010.
2016
Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase.
Biochimica et biophysica acta. 1861(2):130-137 [DOI] 10.1016/j.bbalip.2015.11.003. [PMID] 26569053.
2016
Cell-Permeable Peptide Blocks Tlr4 Signaling and Improves Islet Allograft Survival
Cell Transplantation. 25(7):1319-1329 [DOI] 10.3727/096368916X690449.
2016
Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.
American journal of physiology. Endocrinology and metabolism. 311(2):E530-41 [DOI] 10.1152/ajpendo.00094.2016. [PMID] 27436609.
2016
Irisin Inhibits Atherosclerosis by Promoting Endothelial Proliferation Through microRNA126-5p.
Journal of the American Heart Association. 5(9) [PMID] 27671318.
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
2015
Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts
PLOS ONE. 10(8) [DOI] 10.1371/journal.pone.0136816. [PMID] 26305684.
2015
Maintenance of autoantibody production in pristane-induced murine lupus.
Arthritis research & therapy. 17 [DOI] 10.1186/s13075-015-0886-9. [PMID] 26717913.
2015
Mechanisms of autoantibody production in systemic lupus erythematosus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00228. [PMID] 26029213.
2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis
Cell Death & Differentiation. 22(9):1437-1450 [DOI] 10.1038/cdd.2014.230. [PMID] 25613378.
2015
Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.
American journal of translational research. 7(6):995-1008 [PMID] 26279745.
2014
Bacterial delivery of TALEN proteins for human genome editing.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0091547. [PMID] 24618838.
2014
Histamine-induced Ca2+ signalling is mediated by TRPM4 channels in human adipose-derived stem cells
Biochemical Journal. 463(1):123-134 [DOI] 10.1042/bj20140065.
2014
Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis
PLoS ONE. 9(10) [DOI] 10.1371/journal.pone.0110273. [PMID] 25338001.
2014
Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling.
Diabetes. 63(2):514-25 [DOI] 10.2337/db13-1106. [PMID] 24150604.
2014
Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research & Therapy. 16(1)
2014
Toll-like receptor 7-stimulated tumor necrosis factor α causes bone marrow damage in systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.). 66(1):140-51 [DOI] 10.1002/art.38189. [PMID] 24449581.
2013
Breast Implant-Associated Alk-Negative Anaplastic Large Cell Lymphoma: a Case Report and Discussion of Possible Pathogenesis
International Journal of Clinical and Experimental Pathology. 6:1631-1642
2013
Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology. 190
2013
Genetically Reprogrammed, Liver-Derived Insulin-Producing Cells Are Glucose-Responsive, But Susceptible To Autoimmune Destruction in Settings of Murine Model of Type 1 Diabetes
American Journal of Translational Research. 5:184-199
2013
High level expression, efficient purification and bioactivity assay of recombinant human platelet-derived growth factor AA dimer (PDGF-AA) from methylotrophic yeast Pichia pastoris.
Protein expression and purification. 91(2):221-7 [DOI] 10.1016/j.pep.2013.08.008. [PMID] 23978536.
2013
Novel Autoantigens in Type 1 Diabetes
American Journal of Translational Research. 5:379-392
2013
Novel Detection of Pancreatic and Duodenal Homeobox 1 Autoantibodies (Paa) in Human Sera Using Luciferase Immunoprecipitation Systems (Lips) Assay
International Journal of Clinical and Experimental Pathology. 6:1202-1210
2013
Transient receptor potential melastatin 4 channel controls calcium signals and dental follicle stem cell differentiation.
Stem cells (Dayton, Ohio). 31(1):167-77 [DOI] 10.1002/stem.1264. [PMID] 23081848.
2012
Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Blood. 120
2012
In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.
American journal of stem cells. 1(2):114-127 [PMID] 22833839.
2010
Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.
The Journal of biological chemistry. 285(16):12181-9 [DOI] 10.1074/jbc.M109.064238. [PMID] 20106981.
2010
Expression, purification, and characterization of recombinant human pancreatic duodenal homeobox-1 protein in Pichia pastoris.
Protein expression and purification. 72(2):157-61 [DOI] 10.1016/j.pep.2010.04.004. [PMID] 20381624.
2010
Reprogramming Liver Cells Into Insulin-Producing Cells By Pancreatic Transcription Factors
Human Gene Therapy. 21
2009
Treatment of type 1 diabetes with adipose tissue-derived stem cells expressing pancreatic duodenal homeobox 1.
Stem cells and development. 18(10):1399-406 [DOI] 10.1089/scd.2009.0010. [PMID] 19245309.
2008
Hairy Cell Leukemia With Unusual Loss of Cd103 in a Subset of the Neoplastic Population: Immunophenotypic and Cell Cycle Analysis By Flow Cytometry
International Journal of Clinical and Experimental Pathology. 1:381-386
2008
Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation.
Pediatric blood & cancer. 50(2):415-8 [PMID] 17051534.
2008
Transcription Factor Directed Differentiation of Human Embryonic Stem Cells Into the Pancreatic Endocrine Lineage
Cell Research. 18(S1):S109-S109 [DOI] 10.1038/cr.2008.199.
2006
Derivation of Adipocytes from Human Embryonic Stem Cells
Stem Cells and Development. 14(6) [DOI] https://doi.org/10.1089/scd.2005.14.671.
2006
Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors.
Lab Invest. 83-93 [DOI] doi.org/10.1038/labinvest.3700368.
2006
Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation.
Laboratory investigation; a journal of technical methods and pathology. 86(8):829-41 [PMID] 16732298.
2004
DRAQ5-based DNA content analysis of hematolymphoid cell subpopulations discriminated by surface antigens and light scatter properties.
Cytometry. Part B, Clinical cytometry. 58(1):47-52 [PMID] 14994375.
2004
High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells.
Diabetes. 53(12):3168-78 [PMID] 15561947.
2004
In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.
Diabetes. 53(7):1721-32 [PMID] 15220196.
2003
All-trans-retinoic acid induces CD52 expression in acute promyelocytic leukemia.
Blood. 101(5):1977-80 [PMID] 12393392.

Grants

Sep 2017 – Aug 2023
PATHOGENESIS OF PRISTANE-INDUCED LUPUS
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2016 – Aug 2020
Facilitation of stem cell differentiation in severely injured salivary glands
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2015 – Dec 2017
Engineering Irisin for Understanding its Benefits to Obestiy
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Feb 2014 – Jan 2018
Bone marrow stem cell niche dysfunction in human SLE
Role: Principal Investigator
Funding: LUPUS RES INST
Sep 2011 – Aug 2017
Pathogenesis of Autoantibodies in Pristane-Induced Lupus
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS

Contact Details

Phones:
Business:
(352) 265-0071
Emails:
Addresses:
Business Mailing:
PO Box 100275
GAINESVILLE FL 32610
Business Street:
D6-18 DENTAL SCIENCE BUILDING
GAINESVILLE FL 32610