Adult Islet Autoantibody Panel (ICA, GADA, IA-2A, and ZnT8A)
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EmailMethodology:
Indirect immunofluorescence (ICA), radioimmunoassay (GADA, IA-2A), enzyme-linked immunosorbant assay (ZnT8A)
Performed:
Weekly
Reported:
10 - 20 business days
Use:
- Diagnosis of Type 1 Diabetes: The presence of islet cell cytoplasmic autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GADA), insulinoma-2 associated autoantibodies (IA-2A) and/or zinc transporter 8 autoantibodies (ZnT8A) in the serum of patients who have been biochemically diagnosed with diabetes mellitus indicates the presence of autoimmune, type 1 diabetes mellitus (aka type 1A diabetes mellitus).
- Prediction of Type 1 Diabetes: The presence of ICA, GADA, IA-2A and/or ZnT8A in the serum of an asymptomatic individual places the subject at increased risk for the development of type 1 diabetes mellitus.
Specimen Requirements:
Collect blood in a 5 mL serum separator tube. Centrifuge, separate and transfer the serum to a plastic vial. Ship specimens with a frozen cold pack for overnight delivery.
Stability (collection to shipping of the sample):
- Ambient: 24 hours
- Refrigerated: 24 hours
- Frozen: 1 year (Avoid repeated freeze/thaw cycles.)
Reference Values:
-
ICA:
- Negative (quantitative results reported in JDF units): < 10 JDF units
- Positive: ≥ 10 JDF units
-
GADA:
- Negative: < 1.1
- Positive: ≥ 1.1 U/mL
-
IA-2A:
- Negative: < 0.76
- Positive: ≥ 0.76ICA: 86337, 88347\
-
ZnT8A:
- Negative:< 15 U/mL
- Positive: ≥ 15 U/mL
CPT Code (s):
-
ICA: 86337, 88347
-
GADA: 86341
-
IA-2A: 86341
- ZnT8A: 86341
