Anti-Beta-2 Glycoprotein 1 Antibodies, IgG & IgM

Methodology: 
Enzyme- linked immunosorbent assay (ELISA), INOVA Diagnostics, Inc.
Performed: 
Monday - Friday
Reported: 
Within 6 days
Use: 

This assay is used in the diagnosis of antiphospholipid
syndrome.

Vascular Thrombosis: One or more clinical episodes of arterial, venous or small-vessel thrombosis in any
tissue or organ.

Pregnancy Morbidity:
  • One or more unexplained deaths of a morphologically normal fetus at or beyond the tenth week of gestation, with normal fetal morphology documented by ultrasound.
  • One or more premature births of a morphologically normal neonate before the 34th week of gestation because of (a) eclampsia or severe preeclampsia divined according to standard definitions or (b) recognized features of placental insufficiency.
  • Three or more unexplained consecutive spontaneous abortions before the tenth week of gestation, with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes excluded.
Laboratory criteria for the antiphospholipid syndrome include:
  • Anti-β2 glycoprotein-I antibody of IgG and/or IgM isotype in serum or plasma (in titer > the 99th percentile)
Specimen Requirements: 
One 4 mL light-blue-cap tube (3.2% sodium citrate)
 
Unacceptable Conditions:
  • Ambient
  • Frozen
  • Specimens greater than 24 hours old
Stability (collection to initiation of testing):
  • Ambient: Unacceptable
  • Refrigerated: 24 hours
  • Frozen: Unacceptable
Reference Values: 
Normal:
  • β2 GPI IgG ≤ 20 SGU U/mL
  • β2 GPI IgM ≤ 20 SMU U/mL
Positive:
  • β2 GPI IgG > 20 SGU U/mL
  • β2 GPI IgM > 20 SMU U/mL
CPT Code (s): 
86146 x 2
Notes: 

UFHPL Test #: 60020

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