Antinuclear Antibodies (ANA) Comprehensive Profile

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86225, 86235 (x 8)

Container/Tube: Red-top tube or gel-barrier tube

Sample Volume: 1 mL

Minimum Volume: 0.5 mL (Repeat testing is not possible with this specimen volume.)

Stability (collection to time of analysis/testing):

• Ambient: 14 days
• Refrigerated: 14 days
• Frozen: 14 days
• Freeze/Thaw Cycles: Stable (x 3)

This test is used to detect antibodies associated with SLE and mixed connective tissue disease. Anti-Sm is highly specific for SLE. Anti-RNP is found with a variety of rheumatoid diseases. RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1 are extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells.

The test includes:

• Anticentromere B antibodies
• Anti-dsDNA
• Antichromatin antibodies
• Anti-Jo-1; RNP antibodies
• Antiscleroderma 70 antibodies
• Smith antibodies
• Sjögren anti-SS-A
• Sjögren anti-SS-B