Basic Endocrine Autoantibodies Panel

Methodology: 
Indirect immunofluorescence, radioimmunoassay
Performed: 
Weekly
Reported: 
1 - 7 business days
Use: 
  • Diagnosis of an Autoimmune Endocrine Disorder: In the presence of clinical endocrine disease, an autoantibody directed against the affected gland indicates an autoimmune etiology for the glandular dysfunction.
     
  • Prediction of an Autoimmune Endocrine Disorder: Endocrine autoantibodies detected in an asymptomatic individual indicate an increased risk for the subsequent development of clinical endocrine disease. It is not recommended that asymptomatic, nondiabetic persons be screened for the presence of islet autoantibodies (e.g., ICA) unless these individuals are part of a research study. Positivity for thyroperoxidase autoantibodies (TPOA) and/or thyroglobulin autoantibodies (TGA) indicates an increased risk for the development of autoimmune thyroid disease. If TPOA or TGA are positive, yearly measurement of TSH anticipating the development of thyroid disease is a reasonable clinical management strategy. Positivity for gastric parietal cell autoantibodies (PCA) indicates an increased risk for autoimmune gastritis and the development of pernicious anemia. If PCA are positive, yearly measurements of ferritin and vitamin B12 are a reasonable clinical management strategy. Positivity for adrenal cortical autoantibodies (ACA) indicates an increased risk for the development of Addison disease. If ACA are positive, yearly measurements of supine renin and cortisol following cosyntropin injection anticipating the development of primary adrenal insufficiency is a reasonable clinical management strategy. Positivity for steroidal cell autoantibodies (SCA) indicates an increased risk for the development of gonaditis in women of reproductive age.  If SCA are positive, yearly assessment of menstruation and fertility (if desired) is a reasonable clinical management strategy.
Result: 
Interpretive report
Specimen Requirements: 
Collect blood in a 1- 5 mL serum separator tube. Centrifuge, separate and transfer the serum to a plastic vial.
 
Ship specimens with a frozen cold pack for overnight delivery.
 
Stability (collection to shipping of the sample):
  • Ambient: 24 hours
  • Refrigerated: 24 hours
  • Frozen: 1 year (Avoid repeated freeze/thaw cycles.)
Reference Values: 
Negative (interpretive report provided)
CPT Code (s): 
  • 88346
     
  • 88350 (x 5)
     
  • 86800
     
  • 86376
Notes: 
This panel includes the following tests:

If insulin autoantibodies are requested, a preliminary report will be issued whenever the insulin autoantibodies, which have an in-house turnaround time of 20 working days, are not completed with the other tests. A final report will be issued upon completion.

UFHPL Test #: 60050

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