FISH Study: Neoplastic Interphase EWSR1 (22q12) (For Formalin-Fixed Paraffin-Embedded Tissue) (FFPE)

Methodology: 
Interphase nuclei fluorescence in-situ hybridization (FISH) break-apart analyses; previous or concurrent conventional cytogenetic workup recommended (where possible)
Performed: 
Monday - Saturday
Reported: 
5 - 14 days (subject to a broad range of variables)
Use: 

This test is used to detect Ewing’s sarcoma/primitive neuroectodermal tumor and other small round cell tumors sharing EWS rearrangement.

Specimen Requirements: 
  • Formalin-fixed, paraffin-embedded tissues
  • FFPE-isolated nuclei
  • De-paraffinated, four-micron, slide-mounted tissue sections

The identification of tissues/cells to be targeted and DNA probe selection is the responsibility of the requesting or submitting parties.

Tissue sections and tissues utilized to obtain nuclei isolated from paraffin blocks submitted for interphase FISH analysis must include concurrent evaluation by qualified individuals utilizing additional non-FISH morphometric features to ensure that the requested FISH test(s) are applied to the appropriate tissues/cells.

Reference Values: 

By report; interpretive

CPT Code (s): 
  • 88367 x 2 (computer-assisted)
  • 88377 x 2 (manual)
Notes: 

UFHPL Test #: 30175

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