FISH Study: Neoplastic Interphase MLL

Methodology: 
Interphase nuclei fluorescence in-situ hybridization (FISH) break-apart rearrangement analyses; a concurrent or previous conventional cytogenetic workup is required/recommended (where possible)
Performed: 
Monday - Saturday
Reported: 
5 - 12 days
Use: 

This test is used to detect rearrangements involving the MLL gene locus at 11q23, which may result in the formation of a large variety of hybrid gene fusion products and are seen in ALL, AML and bi-phenotypic acute leukemias.

Result: 
Interpretive report
Specimen Requirements: 
  • Bone Marrow Aspirate: Obtain 1 - 2 cc of in a green-top sodium heparin tube and immediately rotate it thoroughly to ensure adequate mixing with the anticoagulant.
  • Bone Marrow Core Biopsy: Deposit samples in a sterile container containing tissue culture medium with antibiotics (RPMI) that have been brought to room temperature before collection.*
  • Peripheral Blood Specimens: Peripheral blood specimens may be submitted in those clinical conditions (i.e. circulating blasts) and/or circumstances (where warranted).

Do not freeze or fix samples in any manner contrary to the maintenance of cell viability. Maintain sample sterility; keep all specimens at room temperature; and deliver samples to the laboratory within 24 - 48 hours. Ship specimens at room temperature for overnight delivery.

Reference Values: 

By report; interpretive

CPT Code (s): 
  • 88271
  • 88275
  • 88291
Notes: 

UFHPL Test #: 30225

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