Group A Streptococcus Direct, DNA Probe

DNA probe
Monday - Friday
This test uses nucleic acid hybridization for the qualitative detection of group A streptococcal RNA as an aid in the diagnosis of group A streptococcal pharyngitis from throat swabs.


Blood and potentially other chemiluminescent substances may interfere with this test. A negative test does not exclude the possibility that the numbers of group A streptococcal cells may be below the level of detection of the assay. Some strains of Streptococcus equi and rare strains of nonhemolytic streptococci which react with group G antisera may result in a false-positive reaction.
Specimen Requirements: 
Type: Swab of posterior oropharynx, tonsil, or other inflamed area
Container/Tube: Copan Double Dacron dry swab in transport tube without medium (red cap)

Sample Volume: One or two swabs

Storage: Throat swabs are transported to the laboratory at room temperature for 48 hours after specimen collection. After receipt in the laboratory, specimens are stored at 2°C to 8°C and tested within 72 hours.
Rejection Criteria:
  • Throat swab that contains visible blood;
  • Improper labeling
  • Inappropriate specimen transport device
  • Specimen received after prolonged delay (more than 48 hours)
  • Source other than throat
CPT Code (s): 

UFHPL Test #: 78070


  • Gen-Probe® Group a Streptococcus Direct Test package insert, Gen-Probe®, Inc., San Diego, California
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