Immunoglobulin A, Quantitative

Methodology: 
Immunoturbidimetric
Performed: 
Monday - Friday
Reported Notes: 
Limitations: If samples containing macroglobulins, cryoglobulin, or cold agglutinins are handled at incorrect temperatures, false low values may result.
Use: 
This test evaluates humoral immunity and monitors therapy in IgA myeloma.
Specimen Requirements: 

Type: Serum

Container/Tube: Red-top tube or gel-barrier tube

Sample Volume:
  • Adult: 1 mL  
  • Pediatric: 0.4 mL

Storage: Store specimens at room temperature.

Stability (collection to time of analysis/testing): 
  • Ambient: 14 days
  • Refrigerated: 14 days
  • Frozen: 14 days
  • Freeze/Thaw cycles: Stable (x3)
Causes for Rejection:
  • Excessive lipemia
Note: The patient's age must be submitted with the test request.
Reference Values: 

IgA Quantitation Reference Intervals
 

Age

Range (mg/dL)

0 - 11 months

11 − 58

1 - 2 years

20 − 101

3 - 6 years

44 − 189

7 - 12 years

62 − 236

13 - 17 years

77 − 278

>18 years

91 − 414

CPT Code (s): 
82784
Notes: 

UFHPL Test #: 28110

UFHPL Epic order code: LAB73

Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially in multiple myeloma and Mediterranean lymphoma. involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG   2 and IgG4. IgA may be decreased in patients with chronic sinopulmonary disease (in ataxia-telangiectasia or congenitally). Patients with congenital IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA and anaphylaxis if transfused. IgA levels may rise with exercise and fall during pregnancy.
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