Saeed R Khan

Saeed R Khan,

Emeritus Prof

Department: MD-PATHOLOGY
Business Phone: (352) 392-3574
Business Email: khan@pathology.ufl.edu

Teaching Profile

Courses Taught
2008
GMS6381 Spec Topics Pathology

Publications

2023
Proposal for pathogenesis-based treatment options to reduce calcium oxalate stone recurrence.
Asian journal of urology. 10(3):246-257 [DOI] 10.1016/j.ajur.2023.01.008. [PMID] 37538166.
2021
Antiurolithic effects of medicinal plants: results of in vivo studies in rat models of calcium oxalate nephrolithiasis-a systematic review.
Urolithiasis. 49(2):95-122 [DOI] 10.1007/s00240-020-01236-0. [PMID] 33484322.
2021
Editorial: Immunity and Inflammatory Response in Kidney Stone Disease.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.795559. [PMID] 34790209.
2021
Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation.
Nature reviews. Nephrology. 17(6):417-433 [DOI] 10.1038/s41581-020-00392-1. [PMID] 33514941.
2020
Immunotherapy for stone disease.
Current opinion in urology. 30(2):183-189 [DOI] 10.1097/MOU.0000000000000729. [PMID] 31913203.
2019
Development of a two-stage in vitro model system to investigate the mineralization mechanisms involved in idiopathic stone formation: stage 1-biomimetic Randall’s plaque using decellularized porcine kidneys.
Urolithiasis. 47(4):321-334 [DOI] 10.1007/s00240-018-1060-z. [PMID] 29777258.
2019
Development of a two-stage model system to investigate the mineralization mechanisms involved in idiopathic stone formation: stage 2 in vivo studies of stone growth on biomimetic Randall’s plaque.
Urolithiasis. 47(4):335-346 [DOI] 10.1007/s00240-018-1079-1. [PMID] 30218116.
2019
NADPH oxidase: a therapeutic target for hyperoxaluria-induced oxidative stress – an update.
Future medicinal chemistry. 11(23):2975-2978 [DOI] 10.4155/fmc-2019-0275. [PMID] 31659918.
2019
Opportunities for future therapeutic interventions for hyperoxaluria: targeting oxidative stress.
Expert opinion on therapeutic targets. 23(5):379-391 [DOI] 10.1080/14728222.2019.1599359. [PMID] 30905219.
2018
Calcium Oxalate Differentiates Human Monocytes Into Inflammatory M1 Macrophages.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01863. [PMID] 30186283.
2018
Development of a personalized diagnostic model for kidney stone disease tailored to acute care by integrating large clinical, demographics and laboratory data: the diagnostic acute care algorithm – kidney stones (DACA-KS).
BMC medical informatics and decision making. 18(1) [DOI] 10.1186/s12911-018-0652-4. [PMID] 30119627.
2018
Modulation of calcium oxalate dihydrate growth by phosphorylated osteopontin peptides.
Journal of structural biology. 204(2):131-144 [DOI] 10.1016/j.jsb.2018.07.010. [PMID] 30016645.
2017
Histological aspects of the “fixed-particle” model of stone formation: animal studies.
Urolithiasis. 45(1):75-87 [DOI] 10.1007/s00240-016-0949-7. [PMID] 27896391.
2017
How do stones form? Is unification of theories on stone formation possible?
Archivos espanoles de urologia. 70(1):12-27 [PMID] 28221139.
2017
Kidney stones.
Nature reviews. Disease primers. 3 [DOI] 10.1038/nrdp.2017.1. [PMID] 28079115.
2017
Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats.
Urolithiasis. 45(4):329-336 [DOI] 10.1007/s00240-017-0978-x. [PMID] 28361470.
2017
Transcriptional study of hyperoxaluria and calcium oxalate nephrolithiasis in male rats: Inflammatory changes are mainly associated with crystal deposition.
PloS one. 12(11) [DOI] 10.1371/journal.pone.0185009. [PMID] 29091707.
2016
Calcium Oxalate Stone Fragment and Crystal Phagocytosis by Human Macrophages.
The Journal of urology. 195(4 Pt 1):1143-51 [DOI] 10.1016/j.juro.2015.11.048. [PMID] 26626217.
2016
Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury.
World journal of urology. 34(1):89-95 [DOI] 10.1007/s00345-015-1563-y. [PMID] 25981400.
2016
Kidney stones.
Nature reviews. Disease primers. 2 [DOI] 10.1038/nrdp.2016.8. [PMID] 27188687.
2016
Role of Osteogenesis in the Formation of Randall’s Plaques.
Anatomical record (Hoboken, N.J. : 2007). 299(1):5-7 [DOI] 10.1002/ar.23275. [PMID] 26414710.
2015
Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys.
The Journal of urology. 193(5):1684-91 [DOI] 10.1016/j.juro.2014.11.093. [PMID] 25437532.
2015
Osteogenic changes in kidneys of hyperoxaluric rats.
Biochimica et biophysica acta. 1852(9):2000-12 [DOI] 10.1016/j.bbadis.2015.06.020. [PMID] 26122267.
2015
The role of Randall’s plaques in urolithiasis. Foreword.
Urolithiasis. 43 Suppl 1(0 1):1-3 [DOI] 10.1007/s00240-014-0721-9. [PMID] 25218780.
2015
Unified theory on the pathogenesis of Randall’s plaques and plugs.
Urolithiasis. 43 Suppl 1(0 1):109-23 [DOI] 10.1007/s00240-014-0705-9. [PMID] 25119506.
2014
Breast-Cancer Risk in Families With Mutations in Palb2
New England Journal of Medicine. 371(6):497-506 [DOI] 10.1056/NEJMoa1400382. [PMID] 25099575.
2014
Calcium oxalate nephrolithiasis and expression of matrix GLA protein in the kidneys.
World journal of urology. 32(1):123-30 [DOI] 10.1007/s00345-013-1050-2. [PMID] 23475213.
2014
Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase.
Urology. 83(2):510.e1-7 [DOI] 10.1016/j.urology.2013.10.038. [PMID] 24360063.
2014
Osteopontin knockdown in the kidneys of hyperoxaluric rats leads to reduction in renal calcium oxalate crystal deposition.
Urolithiasis. 42(3):195-202 [DOI] 10.1007/s00240-014-0649-0. [PMID] 24619192.
2014
Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis.
Translational andrology and urology. 3(3):256-276 [PMID] 25383321.
2014
Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria.
American journal of physiology. Renal physiology. 306(11):F1285-95 [DOI] 10.1152/ajprenal.00057.2014. [PMID] 24598804.
2013
Editorial comment.
Urology. 82(2) [DOI] 10.1016/j.urology.2013.03.066. [PMID] 23796397.
2013
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys.
Oxidative medicine and cellular longevity. 2013 [DOI] 10.1155/2013/462361. [PMID] 23840917.
2013
Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations.
The Journal of urology. 189(3):803-11 [DOI] 10.1016/j.juro.2012.05.078. [PMID] 23022011.
2013
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate.
The Journal of urology. 190(3):1102-9 [DOI] 10.1016/j.juro.2013.02.3229. [PMID] 23499748.
2013
Stress Oxidative: Nephrolithiasis and Chronic Kidney Diseases
Minerva Medica. 104:23-30
2013
The Kidney Sodium-Phosphate Co-Transporter Alters Bone Quality in An Age and Gender Specific Manner
Bone. 53(2):546-553 [DOI] 10.1016/j.bone.2013.01.011. [PMID] 23333524.
2012
Apocynin-treatment reverses hyperoxaluria induced changes in NADPH oxidase system expression in rat kidneys: a transcriptional study.
PloS one. 7(10) [DOI] 10.1371/journal.pone.0047738. [PMID] 23091645.
2012
Association of Randall plaque with collagen fibers and membrane vesicles.
The Journal of urology. 187(3):1094-100 [DOI] 10.1016/j.juro.2011.10.125. [PMID] 22266007.
2012
Is oxidative stress, a link between nephrolithiasis and obesity, hypertension, diabetes, chronic kidney disease, metabolic syndrome?
Urological research. 40(2):95-112 [DOI] 10.1007/s00240-011-0448-9. [PMID] 22213019.
2012
Renal glomerular and tubular injury after gastric bypass in obese rats.
Nutrition (Burbank, Los Angeles County, Calif.). 28(1):76-80 [DOI] 10.1016/j.nut.2011.03.003. [PMID] 21723091.
2012
Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica.
Urological research. 40(6):671-81 [DOI] 10.1007/s00240-012-0483-1. [PMID] 22622371.
2011
Antiurolithic activity of Origanum vulgare is mediated through multiple pathways.
BMC complementary and alternative medicine. 11 [DOI] 10.1186/1472-6882-11-96. [PMID] 22004514.
2011
Crystal/cell interaction and nephrolithiasis.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. 83(1):1-5 [PMID] 21585160.
2011
Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 26(6):1785-96 [DOI] 10.1093/ndt/gfr035. [PMID] 21378157.
2011
Experimentally induced hyperoxaluria in MCP-1 null mice.
Urological research. 39(4):253-8 [DOI] 10.1007/s00240-010-0345-7. [PMID] 21161647.
2011
Prevention of Renal Crystal Deposition By An Extract of Ammi Visnaga L. and Its Constituents Khellin and Visnagin in Hyperoxaluric Rats
Urological research. 39(3):189-195 [DOI] 10.1007/s00240-010-0333-y. [PMID] 21069311.
2011
Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.
PloS one. 6(8) [DOI] 10.1371/journal.pone.0023888. [PMID] 21909374.
2011
Temporal changes in the expression of mRNA of NADPH oxidase subunits in renal epithelial cells exposed to oxalate or calcium oxalate crystals.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 26(6):1778-85 [DOI] 10.1093/ndt/gfq692. [PMID] 21079197.
2011
Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall’s plaques?
The Journal of urology. 186(3):1107-13 [DOI] 10.1016/j.juro.2011.04.109. [PMID] 21784483.
2010
An Aqueous Extract of Ammi Visnaga Fruits and Its Constituents Khellin and Visnagin Prevent Cell Damage Caused By Oxalate in Renal Epithelial Cells
Phytomedicine. 17(8-9):653-658 [DOI] 10.1016/j.phymed.2009.10.011. [PMID] 20036111.
2010
Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats.
Phytotherapy research : PTR. 24(8):1250-5 [DOI] 10.1002/ptr.3196. [PMID] 20564494.
2010
Experimental induction of calcium oxalate nephrolithiasis in mice.
The Journal of urology. 184(3):1189-96 [DOI] 10.1016/j.juro.2010.04.065. [PMID] 20663521.
2010
Mineralogical signatures of stone formation mechanisms.
Urological research. 38(4):281-92 [DOI] 10.1007/s00240-010-0288-z. [PMID] 20625894.
2010
Nephrocalcinosis in animal models with and without stones.
Urological research. 38(6):429-38 [DOI] 10.1007/s00240-010-0303-4. [PMID] 20658131.
2010
Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein.
American journal of physiology. Renal physiology. 299(3):F469-78 [DOI] 10.1152/ajprenal.00243.2010. [PMID] 20591941.
2010
Reduced-intensity conditioning using fludarabine with either antithymocyte globulin and BU, or low-dose TBI allowing allogeneic hematopoietic SCT.
Bone marrow transplantation. 45(1):31-7 [DOI] 10.1038/bmt.2009.126. [PMID] 19543325.
2009
Genetic basis of renal cellular dysfunction and the formation of kidney stones.
Urological research. 37(4):169-80 [DOI] 10.1007/s00240-009-0201-9. [PMID] 19517103.
2009
Herbal medicines in the management of urolithiasis: alternative or complementary?
Planta medica. 75(10):1095-103 [DOI] 10.1055/s-0029-1185719. [PMID] 19444769.
2009
Mechanism of formation of concentrically laminated spherules: implication to Randall’s plaque and stone formation.
Urological research. 37(1):11-7 [DOI] 10.1007/s00240-008-0169-x. [PMID] 19066874.
2009
Superoxide from NADPH oxidase as second messenger for the expression of osteopontin and monocyte chemoattractant protein-1 in renal epithelial cells exposed to calcium oxalate crystals.
BJU international. 104(1):115-20 [DOI] 10.1111/j.1464-410X.2009.08374.x. [PMID] 19220254.
2009
The effect of calcium on calcium oxalate monohydrate crystal-induced renal epithelial injury.
Urological research. 37(1):1-6 [DOI] 10.1007/s00240-008-0160-6. [PMID] 19005647.
2008
A tribute to the life and accomplishments of Birdwell Finlayson.
The Journal of urology. 179(3):842-6; discussion 846 [DOI] 10.1016/j.juro.2007.10.052. [PMID] 18221959.
2008
Apatite induced renal epithelial injury: insight into the pathogenesis of kidney stones.
The Journal of urology. 180(1):379-87 [DOI] 10.1016/j.juro.2008.02.041. [PMID] 18499159.
2008
Calcium oxalate crystal deposition in kidneys of hypercalciuric mice with disrupted type IIa sodium-phosphate cotransporter.
American journal of physiology. Renal physiology. 294(5):F1109-15 [DOI] 10.1152/ajprenal.00620.2007. [PMID] 18337544.
2008
Direct AFM measurements of adhesion forces between calcium oxalate monohydrate and kidney epithelial cells in the presence of Ca2+ and Mg2+ ions.
Journal of colloid and interface science. 325(2):594-601 [DOI] 10.1016/j.jcis.2008.06.024. [PMID] 18619606.
2008
Prevention of Nephrolithiasis By An Extract of Ammi Visnaga L, in Stone Forming Rats
Planta Medica. 74
2007
Dietary oxalate and calcium oxalate nephrolithiasis.
The Journal of urology. 178(5):2191-6 [PMID] 17870111.
2007
Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals.
BJU international. 100(4):891-7 [PMID] 17550416.
2006
Adhesion force between calcium oxalate monohydrate crystal and kidney epithelial cells and possible relevance for kidney stone formation.
Journal of colloid and interface science. 300(1):131-40 [PMID] 16677664.
2006
Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline.
Kidney International. 70(5):914-23 [DOI] 10.1038/sj.ki.5001699. [PMID] 16850024.
2006
Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts.
BJU international. 98(3):656-60 [PMID] 16925768.
2006
Re: Dietary oxalate loads and renal oxalate handling. R. P. Holmes, W. T. Ambrosius and D. G. Assimos.
The Journal of urology. 175(4):1576; author reply 1576-7 [PMID] 16516052.
2006
Reactive oxygen species mediated calcium oxalate crystal-induced expression of MCP-1 in HK-2 cells.
Urological research. 34(1):26-36 [PMID] 16397773.
2006
Renal tubular damage/dysfunction: key to the formation of kidney stones.
Urological research. 34(2):86-91 [PMID] 16404622.
2006
Role of lipids in urinary stones: studies of calcium oxalate precipitation at phospholipid langmuir monolayers.
Langmuir : the ACS journal of surfaces and colloids. 22(6):2450-6 [PMID] 16519440.
2005
Atomic force microscopy measurement of the elastic properties of the kidney epithelial cells.
Journal of Colloid and Interface Science. 285(1):125-35 [DOI] 10.1016/j.jcis.2004.11.041. [PMID] 15797405.
2005
Citrate and vitamin E blunt the shock wave-induced free radical surge in an in vitro cell culture model.
Urological research. 33(6):448-52 [PMID] 16317535.
2005
Citrate provides protection against oxalate and calcium oxalate crystal induced oxidative damage to renal epithelium.
The Journal of urology. 173(2):640-6 [PMID] 15643280.
2005
Diphenyleneiodium (DPI) reduces oxalate ion- and calcium oxalate monohydrate and brushite crystal-induced upregulation of MCP-1 in NRK 52E cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 20(5):870-8 [PMID] 15755756.
2005
Hyperoxaluria-induced oxidative stress and antioxidants for renal protection.
Urological research. 33(5):349-57 [PMID] 16292585.
2005
Oxalate induced expression of monocyte chemoattractant protein-1 (MCP-1) in HK-2 cells involves reactive oxygen species.
Urological research. 33(6):440-7 [PMID] 16307291.
2005
Oxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cells.
The Biochemical journal. 387(Pt 3):609-16 [PMID] 15533056.
2004
Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies.
Clinical and experimental nephrology. 8(2):75-88 [PMID] 15235923.
2004
Effect of angiotensin II receptor blockage on osteopontin expression and calcium oxalate crystal deposition in rat kidneys.
Journal of the American Society of Nephrology : JASN. 15(3):635-44 [PMID] 14978165.
2004
Modulators of urinary stone formation.
Frontiers in bioscience : a journal and virtual library. 9:1450-82 [PMID] 14977559.
2004
Role of renal epithelial cells in the initiation of calcium oxalate stones.
Nephron. Experimental nephrology. 98(2):e55-60 [PMID] 15499208.
2003
Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species.
Kidney international. 64(4):1283-91 [PMID] 12969146.
2003
Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 18(4):664-9 [PMID] 12637633.
2003
Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants.
Urological research. 31(1):3-9 [PMID] 12624656.
2003
Protective role of heparin/heparan sulfate on oxalate-induced changes in cell morphology and intracellular Ca2+.
Urological research. 31(3):198-206 [PMID] 12719948.
2002
Aggregation and dispersion characteristics of calcium oxalate monohydrate: effect of urinary species.
Journal of colloid and interface science. 256(1):168-74 [PMID] 12505509.
2002
Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis.
The Journal of urology. 168(3):1173-81 [PMID] 12187263.
2002
Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells.
Kidney international. 61(1):105-12 [PMID] 11786090.
2002
Quantification of proteins extracted from calcium oxalate and calcium phosphate crystals induced in vitro in the urine of healthy controls and stone-forming patients.
Urologia internationalis. 68(1):54-9 [PMID] 11803269.
2002
Stone research on the bench: where we are and where we are going.
Journal of endourology. 16(6):413-6 [PMID] 12227916.
2000
Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals.
Molecular Urology. 4(4):305-12 [PMID] 11156696.
1999
Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells.
Journal of the American Society of Nephrology. 10 Suppl 14:S457-63 [PMID] 10541283.

Grants

Aug 2013 – Jul 2018
Training Program in Urologic Research
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
May 2012 – Apr 2017
An In Vitro Model for Studying the Role of Acidic Proteins in Randalls Plaque and Stone Formation
Role: Project Manager
Funding: NATL INST OF HLTH

Contact Details

Phones:
Business:
(352) 392-3574
Emails:
Addresses:
Business Mailing:
PO Box 100275
GAINESVILLE FL 32610
Business Street:
D6-33C DSB
GAINESVILLE FL 32611