Levetiracetam (Keppra)

Methodology: 
Liquid chromatography/Tandem mass spectrometry (LC-MS/MS)
Performed: 
As needed
Reported: 
Within 3 days
Use: 
This test is used for the quantitation of levetiracetam, an anti-epileptic drug, in serum/plasma.
Specimen Requirements: 

Collect at least 2mL of blood in a plain red-top or lavender-top (EDTA) serology tube. Centrifuge the blood and remove the serum/plasma from the cells within two hours of collection.

Transport/Storage Temperature:
  • Refrigerated
Stability (collection to shipping of the sample):
  • Ambient: 7 days
  • Refrigerated: 7 days
  • Frozen (-20 º C): 30 days
Rejection Criterion:
  • Do not submit specimens in serum-separator tubes (SST), as the gel in the tube may absorb the levetiracetam.
Reference Values: 
Therapeutic range: 12 - 46 μg/ml
CPT Code (s): 
80177
Notes: 

UFHPL Test #: 

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