Chromosome Study: Neoplastic Marrow/Blood

CPT Code(s):

  • 88237
  • 88262
  • 88291


Classic cytogenetic G-band analysis (karyotyping); requires cell culture


Monday - Saturday


7 - 14 days


This test is used to identify clonal chromosome changes by conventional karyotyping methods for the diagnosis and classification of various hematological disorders.

Specimen Requirements:

Bone Marrow Aspirate: Obtain 1 - 2 cc of aspirate in a green-top sodium heparin tube and immediately rotate it thoroughly to ensure adequate mixing with the anticoagulant.

Bone Marrow Core Biopsy: Deposit the sample in a sterile container containing RPMI or tissue culture medium with antibiotics, which has been brought to room temperature prior to collection.*

Peripheral Blood Specimens: These may be submitted in certain clinical conditions (e.g., circulating blasts) and/or circumstances where warranted.

Unacceptable Conditions:

  • Frozen specimens
  • Specimens greater than 48 hours old*
Stability (collection to initiation of testing):

  • Ambient: 24 - 48 hours old*
  • Frozen: Unacceptable

* Cell viability of specimens requiring cell culture may be compromised in specimens greater than 48 hours old upon receipt. Refrigeration at 2° - 8° C may assist when a delay in delivery is unpreventable. Do not freeze or place specimens directly on ice.

No formalin-, alcohol- or paraffin-preserved specimens. Do not freeze or fix samples in any manner contrary to the maintenance of cell viability. Maintain sample sterility; keep all specimens at room temperature; and deliver samples to the laboratory within 24 - 48 hours. Ship specimens at room temperature for overnight delivery.

Collection Procedure:


Reference Values:

By report; interpretive

Interpretation Data:



UFHPL Test #: 30040

Reported Notes:



By report; interpretive