Insulin Autoantibodies (IAA)

Additional Information:

EPIC Test Name: INSULIN AUTOANTIBODY

CPT Code(s):

86337

Specimen Requirements:

Type: Serum
Container/Tube: SST
Sample Volume: 1 mL
Minimum Volume: 0.4 mL (Repeat testing is not possible with this specimen volume.)
Storage: Centrifuge, separate and transfer the serum to a plastic vial. Ship specimens with a frozen cold pack for overnight delivery.
Stability (collection to time of analysis/testing):

  • Refrigerated: 24 hours
  • Frozen: 1 year

Use:

  • Diagnosis of Type 1 Diabetes: The presence of autoantibodies against insulin (IAA) in patients with diabetes mellitus indicates the presence of autoimmune, type 1 diabetes. It is advised that blood for IAA testing be drawn before insulin therapy is initiated. For the IAA result to be valid, the patient must not be insulin treated for more than 1 week.
  • Prediction of Type 1 Diabetes: Autoantibodies against insulin in an asymptomatic individual places the subject at increased risk for the development of type 1 diabetes.

Methodology:

Radioimmunoassay

Reported:

7 - 20 Business Days

Reference Values:

  • Negative: < 95 nU/mL
  • Indeterminate: 95 - 124 nU/mL
  • Positive: > 125 nU/mL

Performed:

Monthly