Prostate-Specific Antigen (PSA), Total

CPT Code(s):



Chemiluminescent immunometric assay


Monday - Friday


Within 3 days


Prostate-specific antigen has been found to be primarily associated with prostate tissue, and elevated serum PSA has been found in patients with prostate cancer, benign prostatic hypertrophy and inflammatory conditions of other adjacent genitourinary tissues, but not in healthy men and men with nonprostatic carcinoma.

The American Cancer Society recommends that both the PSA blood test and digital rectal examination be offered annually, beginning at age 50, to men who have at least a 10-year life expectancy, as well as younger men who are at high risk.

Specimen Requirements:

Collect blood by venipuncture into an SST/gold-top tube. For serum, allow the specimens to clot at room temperature. Separate the serums from the cells, using a refrigerated centrifuge and avoid hemolysis. If possible, keep specimens cold (2 - 8°C).

Stability (collection to time of analysis/testing):

  • Refrigerated (2 - 8°C): 48 hours
  • Frozen (-20°C): Indefinitely

Collection Procedure:


Reference Values:

< 4.0 ng/mL

Interpretation Data:




Reported Notes: