Thyroglobulin Autoantibodies (TGA)

Methodology: 
Radioimmunoassay
Performed: 
Weekly
Reported: 
1 - 3 days
Use: 
  • Diagnosis of Autoimmune Thyroid Disease: The detection of either thyroperoxidase autoantibodies (TPOA) or thyroglobulin autoantibodies (TGA) in the presence of biochemically defined hypothyroidism or euthyroid goiter identifies an autoimmune etiology as the cause of the subject’s thyroid disease.
     
  • Prediction of Autoimmune Thyroid Disease: The detection of TPOA and/or TGA in an asymptomatic individual indicates an increased risk for the subsequent development of auto immune thyroid disease that can produce goiter and/or either hypothyroidism (Hashimoto thyroid or atropic thyroiditis) or hyperthyroidism (Graves’ disease).
Specimen Requirements: 

Collect blood in a 1- 5 mL serum separator tube. Centrifuge, separate and transfer the serum to a plastic vial. Ship specimens with a frozen cold pack for overnight delivery.

Stability (collection to shipping of the sample):
  • Ambient: 24 hours
  • Refrigerated: 24 hours
  • Frozen: 1 year (Avoid repeated freeze/thaw cycles.)
    • For specimen storage < 7 days: Store at 2 - 8° C
    • For specimen storage < 6 months: Store at -20° C
Reference Values: 

Negative

CPT Code (s): 

86800

Notes: 
  • Reference Range: < 40 IU/mL
  • Reportable Range: 20 - 3000 IU/mL
  • Analytical Sensitivity: 2.2 IU/mL

UFHPL Test #: 60145

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