Marguerite Hatch, PhD
Dr. Hatch’s general interests are focused on the mechanisms and control of electrolyte and solute transport across epithelial membranes. She is particularly interested in transport mechanisms for the oxalate anion across intestinal and renal epithelial in the context of calcium oxalate kidney stone disease and primary hyperoxaluria.
Current investigations in Dr. Hatch’s laboratory are focused on several anion exchangers in the SLC26A gene family that are involved in epithelial oxalate transport. Using a variety of transport physiology and molecular biology approaches and studies that include whole animal (mouse knockout models) and tissue (intestine and kidney), in addition to cell culture studies, her team evaluates the contribution of specific transport proteins to epithelial movements of oxalate. Dr. Hatch also focuses on the physiological interaction between the gut-resident oxalobacter formigenes and the enterocyte, which results in alterations of intestinal oxalate transport and enteric elimination of oxalate and leads to reduced renal excretion of this stone-forming compound.