Saeed R. Khan, PhD
Dr. Khan’s laboratory is involved in investigating pathogenesis of calcium oxalate (CaOx) nephrolithiasis using in-vitro and in-vivo techniques. Their studies suggest that stone formation is a result of both renal and extra renal events. High urinary oxalate and crystals lead to the development of oxidative stress in the kidneys, leading to localized inflammation and fibrosis followed by the formation of calcium phosphate plaques, the so-called Randall’s plaques (RP) inside the kidneys. The plaques grow by further mineralization of renal interstitial collagen fibers eventually reaching the renal papillary surface and becoming exposed to the pelvic urine. CaOx crystals deposit on the RPs and develop into CaOx stones.
The laboratory currently has two grants. One supports investigations of the pathways involved in the formation of reactive oxygen species and development of oxidative stress when renal cells become exposed to oxalate and various types of urinary crystals (The emphasis is on NADPH oxidase.). The other grant involves study of the CaOx crystal deposition on the RPs.