Mark A Atkinson

Mark A Atkinson,

Eminent Scholar

Department: MD-PATHOLOGY
Business Phone: (352) 273-8278
Business Email: atkinson@ufl.edu

About Mark A Atkinson

Dr. Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida. He also is the Director of the Diabetes Institute at UF. The author of nearly 600 publications, Dr. Atkinson is beginning his 37th year of investigation into the field of type 1 diabetes. Dr. Atkinson has been the recipient of multiple scientific and humanitarian based awards for these efforts. Those include each of the three from the Juvenile Diabetes Research Foundation (JDRF). The first was the Gerold and Gayla Grodsky award (2001) provided to the outstanding Ph.D. investigating type 1 diabetes. He is a three-time recipient of the Mary Tyler Moore & S. Robert Levine M.D. award for translational research on type 1 diabetes (2004, 2008, and 2014). He was also the recipient of the JDRF’s David Rumbough award for contributions to diabetes research (2005) and the prestigious Eli Lilly Award for Outstanding Scientific Achievement from the American Diabetes Association (ADA) (2004). He also received the Barbara Davis Award for contributions to the field seeking to prevent type 1 diabetes (2015), the Claes Hellerström Award (Sweden) for his efforts promoting pancreas research in this disease (2016), and the 2016 recipient of the outstanding alumni award from his alma mater (The University of Michigan-Dearborn). Most recently, he received the UF College of Medicine Lifetime Achievement Award (2018), the ADA Humanitarian Award (2018) and the ADA Albert Renold Award (2018), College of Medicine Wall of Fame Award (2019), and the Jacobaeus Award from the Novo Nordisk Foundation (2019; the most prestigious international award in Endocrinology and Metabolism). He has also engaged in leadership service to the type 1 diabetes community, with active administrative or advisory service to JDRF, The American Diabetes Association (ADA), The National Institutes of Health, The Immunology of Diabetes Society, and a variety of companies from the pharmaceutical and biotech industry. At present, this includes service as the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program, and he recently completed his term as Steering Committee Chair of the NIH Human Islet Research Network (HIRN); both organizations are directed at major questions in type 1 diabetes with international recognition and impact. He is also a long-standing member of the NIH TrialNet effort, having served in a number of leadership capacities with that organization since its inception. Dr. Atkinson is also one of nine members of the Brehm Coalition for Type 1 Diabetes Research, as well as one of four initial members of the Leona M. and Harry B. Helmsley Charitable Trust’s Type 1 Diabetes Research Initiative. He has served on the state, regional, as well as the national Board of Directors for the ADA, as well as past-memberships on their publications, scientific sessions planning, research review committees. He recently completed service as an Associate Editor of the ADA’s Journal Diabetes and now serves as ad hoc Editor-in-Chief of that journal as well as Diabetes Care. Dr. Atkinson is an internationally recognized authority on multiple aspects pertaining to type 1 diabetes, with particular interests in disease prediction and prevention, the role for environment in the initiation of the disease, stem cells and pancreatic regeneration, the use of animal models in studies of type 1 diabetes pathogenesis and therapy, and the identification of markers of tolerance and immunoregulation. In 2019, Dr. Atkinson surpassed $75M in total extramural funding for his career. With respect to the notions of prevention and cure of type 1 diabetes, Dr. Atkinson has extensively contributed to the performance of some seven “bench to bedside” trials. He has been active in terms of training and education of the next generation of diabetes researchers in many ways throughout his career, including service (two terms) on the NIH NIDDK Training Study Section, undertaking/publishing a 30 year research study on the effectiveness of JDRF training programs, as well as personal mentoring to over 30 graduate students/post-doctoral fellows/clinical fellows/young faculty (K awardees). Dr. Atkinson has been the recipient of numerous funding awards. Finally, he is President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world.

Accomplishments

Jacobaeus Award in Endocrinology and Metabolism
2019 · Novo Nordisk Foundation
Wall of Fame – UF College of Medicine Alumni
2019 · College of Medicine, University of Florida
Albert Renold Award
2018 · American Diabetes Association
Alex and Ani Invisible Angel Award
2018 · JDRF
Humanitarian Award
2018 · American Diabetes Association
University of Florida College of Medicine Lifetime Achievement Award
2018 · University of Florida
Claes Hellerstrom Award
2016 · Upsalla, Sweden
Mary Tyler Moore and S. Robert Levine Clinical Research Award
2015 · JDRF
Julio Santiago Award
2014 · Washington University St. Louis
Davis Award
2012 · Children with Diabetes Foundation
Service Award
2011 · American Diabetes Association
Honorary Lecturer (with Award)
2010 · Edwin Gale Retirement event
Cure Award
2009 · American Diabetes Association
Exemplary Teacher Award
2009 · Univeristy of Florida, College of Medicine
Mary Tyler Moore and S. Robert Levine Clinical Research Award
2008 · Juvenile Diabetes Research Foundation
Howard Hughes Medical Institute undergraduate professor
2007 · University of Florida
Distinguished Service Award for serving as Chair of the Immunology, Immunogenetics, and Transplantation Council
2006 · American Diabetes Association
University of Florida Research Professor
2006 · University of Florida
David Rumbough Award for Scientific Excellence
2005 · JDRF
Hilborn Scholar
2005 · UCLA School of Medicine
Eli Lilly Award for Outstanding Scientific Achievement
2004 · American Diabetes Association
Mary Tyler Moore and S. Robert Levine Clinical Research Award
2004 · Juvenile Diabetes Research Foundation
Distinguished Visiting Professor
2003 · Johns Hopkins University School of Medicine
Gerold & Kayla Grodsky Award for Major Contributions to Diabetes Research
2003 · Juvenile Diabetes Research Foundation
Mary Jane Krugal Research Award
2003 · Juvenile Diabetes Research Foundation
Faculty Basic Science Research Award
2001 · College of Medicine, University of Florida
Outstanding Research Achievement Award
2000 · American Diabetes Association (South Costal Region)
“Distinguished Faculty”
2000 · Juvenile Diabetes Research Foundation
Congressional Briefing on Type 1 Diabetes
1999 · United States Congress
Mary Jane Krugal Research Award
1999 · Juvenile Diabetes Research Foundation
Elected Executive Board Member
1998 · Immunology of Diabetes Society
Sebastian Family / American Diabetes Association Endowed Chair
1998 · American Diabetes Association
University of Florida Research Foundation Professorship
1998 · University of Florida
Mary Jane Krugal Research Award
1997 · Juvenile Diabetes Research Foundation
Partners for a Cure Award
1996 · American Diabetes Association (Florida)
Career Development Award
1993 · Juvenile Diabetes Association
Diabetes Research and Education Foundation Award
1992 · American Diabetes Association
FIRST Award
1992 · National Institutes of Health
Research Development Award (CDA)
1990 · American Diabetes Association
Post-Doctoral Fellowship
1988 · Juvenile Diabetes Research Foundation
Post-Doctoral Fellowship (Mentor Based)
1988 · American Diabetes Association
Medical Guild Research Award for Graduate Research
1987 · University of Florida
Division of Sponsored Research Award
1986 · University of Florida

Teaching Profile

Courses Taught
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation

Clinical Profile

Much of my research effort over these past three decades has been either translational in scope (i.e., bench to bedside), addressing issues of clinical immunology, contributing to the design and performance of clinical trials, or addressing how type 1 diabetes develops in humans through studies of pancreatic pathology / genetics, or immunology.

Research Profile

When a first year graduate student at The University of Florida in 1984, my Mentor provided words of advice that remain a major part of my academic life. In a conversation regarding what areas would form the best focus for a research career in T1D, he responded, “If you pursue three avenues of investigation and find out their answers, you will make a valuable contribution to type 1 diabetes (sic)”. Those recommended efforts were to: • Determine what causes type 1 diabetes. • Identify a means to predict, months to years in advance, who will develop the disease. • Develop a method to cure type 1 diabetes.

Now some 35 years later, with both a sense of happiness and sadness, I can say that these three avenues remain a major focus of my research efforts. Happiness, in that progress has been made by the research community (with some contributions from my research group and collaborators) towards each goal, but at the same time none have been fully addressed. Indeed, progress towards each goal differs quite dramatically. For example, we and others have, to a large extent, developed a means to predict in a population of individuals who is likely to develop T1D. This is a major (if even partial) success. At the same time, its impact remains somewhat muted in that without an answer to the third goal (a method to prevent or cure the disease), efforts for disease prediction have been somewhat underutilized by the public health care community. That said, we are moving closer (and leading efforts) towards testing of agents capable of effectively intervening in the disease which leaves open the discussion of progress towards the first goal, understanding what causes the disorder. Sadly, of all the goals, this one remains the most elusive. Perhaps in part because of this state of progress, I have expanded my efforts to seeing insulin provided to those in third world areas as while not a cure, it does represent a life-saving entity.

Open Researcher and Contributor ID (ORCID)

0000-0001-8489-4782

Areas of Interest
  • type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, metabolism

Publications

2024
An antigen-specific immunotherapeutic, AKS-107, deletes insulin-specific B cells and prevents murine autoimmune diabetes.
Frontiers in immunology. 15 [DOI] 10.3389/fimmu.2024.1367514. [PMID] 38515750.
2024
Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
Diabetes. 73(1):11-22 [DOI] 10.2337/dbi20-0018. [PMID] 38117999.
2024
Diabetes Study of Children of Diverse Ethnicity and Race: Study design.
Diabetes/metabolism research and reviews. 40(3) [DOI] 10.1002/dmrr.3744. [PMID] 37888801.
2024
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Nature communications. 15(1) [DOI] 10.1038/s41467-023-44090-5. [PMID] 38172101.
2024
Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.02.08.579175. [PMID] 38405840.
2024
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes.
Diabetes care. 47(2):285-289 [DOI] 10.2337/dc23-1750. [PMID] 38117469.
2024
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
Nature cell biology. 26(3):421-437 [DOI] 10.1038/s41556-024-01368-0. [PMID] 38409327.
2023
A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.
Scientific data. 10(1) [DOI] 10.1038/s41597-023-02244-6. [PMID] 37237059.
2023
CGM Metrics Identify Dysglycemic States in Participants From the TrialNet Pathway to Prevention Study
Diabetes Care. 46(3):526-534 [DOI] 10.2337/dc22-1297. [PMID] 36730530.
2023
Corrigendum to “Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study” [eBioMedicine 83 (2022) 104208].
EBioMedicine. 98 [DOI] 10.1016/j.ebiom.2023.104860. [PMID] 37918220.
2023
Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination.
Journal of perinatology : official journal of the California Perinatal Association. 43(6):775-781 [DOI] 10.1038/s41372-022-01581-5. [PMID] 36631564.
2023
Disease progression joint model predicts time to type 1 diabetes onset: Optimizing future type 1 diabetes prevention studies.
CPT: pharmacometrics & systems pharmacology. 12(7):1016-1028 [DOI] 10.1002/psp4.12973. [PMID] 37186151.
2023
Divergent metabolic phenotypes in two genetic syndromes of low insulin secretion.
Diabetes research and clinical practice. 196 [DOI] 10.1016/j.diabres.2022.110228. [PMID] 36549505.
2023
Editorial response to Cosentino and Marino RE: detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination.
Journal of perinatology : official journal of the California Perinatal Association. 43(6):828-829 [DOI] 10.1038/s41372-023-01660-1. [PMID] 37024528.
2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes.
JCI insight. 8(17) [DOI] 10.1172/jci.insight.170767. [PMID] 37498686.
2023
Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity.
Nature immunology. 24(8):1370-1381 [DOI] 10.1038/s41590-023-01557-3. [PMID] 37460638.
2023
Insulin thermostability in a real-world setting.
The lancet. Diabetes & endocrinology. 11(5):310-312 [DOI] 10.1016/S2213-8587(23)00028-1. [PMID] 37003280.
2023
Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants
Diabetologia. 66(1):127-131 [DOI] 10.1007/s00125-022-05818-y. [PMID] 36282337.
2023
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients.
Cell reports. Medicine. 4(6) [DOI] 10.1016/j.xcrm.2023.101079. [PMID] 37327781.
2023
Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes.
Advanced materials (Deerfield Beach, Fla.). 35(40) [DOI] 10.1002/adma.202300812. [PMID] 37357903.
2023
Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies
Diabetes Care. 46(5):1098-1105 [DOI] 10.2337/dc22-2236. [PMID] 37000695.
2023
Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.02.16.528701. [PMID] 36824909.
2023
Reducing Bias in Academic Publishing: TheDiabetes CareApproach
Diabetes Care. 46(4):665-666 [DOI] 10.2337/dci23-0014.
2023
Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes
JCI Insight. 8(16) [DOI] 10.1172/jci.insight.161812. [PMID] 37432736.
2023
Serum from pregnant donors induces human beta cell proliferation and insulin secretion.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.04.17.537214. [PMID] 37131658.
2023
Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood.
Immunity. 56(8):1894-1909.e5 [DOI] 10.1016/j.immuni.2023.06.008. [PMID] 37421943.
2023
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas.
Cell metabolism. 35(9):1500-1518 [DOI] 10.1016/j.cmet.2023.06.018. [PMID] 37478842.
2023
The role of health system penetration rate in estimating the prevalence of type 1 diabetes in children and adolescents using electronic health records.
Journal of the American Medical Informatics Association : JAMIA. 31(1):165-173 [DOI] 10.1093/jamia/ocad194. [PMID] 37812771.
2023
Time for changes in type 1 diabetes intervention trial designs.
The lancet. Diabetes & endocrinology. 11(11):789-791 [DOI] 10.1016/S2213-8587(23)00262-0. [PMID] 37802093.
2022
A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. 119(31) [DOI] 10.1073/pnas.2120028119. [PMID] 35878027.
2022
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Mali.
Pediatric diabetes. 23(8):1552-1559 [DOI] 10.1111/pedi.13411. [PMID] 36062396.
2022
Commercially Available Insulin Products Demonstrate Consistency With Product Labeling Throughout All Seasons in the U.S.
Diabetes Care. 45(11):e166-e168 [DOI] 10.2337/dc22-0972.
2022
Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination.
Research square. [DOI] 10.21203/rs.3.rs-1950944/v1. [PMID] 36032985.
2022
Erratum. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes 2021;70:1623-1633.
Diabetes. 71(6) [DOI] 10.2337/db22-er06a. [PMID] 35380651.
2022
Erratum. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes Care 2021;44:1734-1743.
Diabetes care. 45(6) [DOI] 10.2337/dc22-er06b. [PMID] 35380617.
2022
Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes
Journal of the Endocrine Society. 6(11) [DOI] 10.1210/jendso/bvac136. [PMID] 36249412.
2022
Exploration of autoantibody responses in canine diabetes using protein arrays.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-06599-5. [PMID] 35169238.
2022
Improving the Prediction of Type 1 Diabetes Across Ancestries.
Diabetes care. 45(3):e48-e50 [DOI] 10.2337/dc21-1254. [PMID] 35043156.
2022
Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings From Florida
Diabetes. 71(12):2702-2706 [DOI] 10.2337/db22-0549. [PMID] 36094294.
2022
Limited extent and consequences of pancreatic SARS-CoV-2 infection.
Cell reports. 38(11) [DOI] 10.1016/j.celrep.2022.110508. [PMID] 35247306.
2022
Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening
Diabetes Care. 45(12):2982-2990 [DOI] 10.2337/dc22-1362. [PMID] 36326757.
2022
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicine. 83 [DOI] 10.1016/j.ebiom.2022.104208. [PMID] 35952496.
2022
Response to Comment on Dunne et al. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes Care 2021;44:1734-1743.
Diabetes care. 45(5) [DOI] 10.2337/dci21-0055. [PMID] 35561137.
2022
The pathogenesis, natural history, and treatment of type 1 diabetes: time (thankfully) does not stand still.
The lancet. Diabetes & endocrinology. 10(2):90-92 [DOI] 10.1016/S2213-8587(21)00344-2. [PMID] 34951951.
2022
The Transition From a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk.
Diabetes care. 45(10):2264-2270 [DOI] 10.2337/dc22-0167. [PMID] 35998266.
2022
Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program.
Cell metabolism. 34(12):1906-1913 [DOI] 10.1016/j.cmet.2022.09.013. [PMID] 36206763.
2022
α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals.
The Journal of clinical investigation. 132(11) [DOI] 10.1172/JCI156243. [PMID] 35642629.
2021
ACE2 chromogenic immunostaining protocol optimized for formalin-fixed paraffin-embedded human tissue sections.
STAR protocols. 2(3) [DOI] 10.1016/j.xpro.2021.100696. [PMID] 34308375.
2021
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes
Diabetologia. 64(10):2279-2291 [DOI] 10.1007/s00125-021-05501-8. [PMID] 34274990.
2021
Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
Diabetes. 70(5):1038-1050 [DOI] 10.2337/dbi20-0034. [PMID] 33947721.
2021
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.
Pediatric diabetes. 22(5):749-757 [DOI] 10.1111/pedi.13209. [PMID] 33837995.
2021
Correction to: Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes.
Metabolomics : Official journal of the Metabolomic Society. 18(1) [DOI] 10.1007/s11306-021-01865-5. [PMID] 34923611.
2021
Defining a cure for type 1 diabetes: a call to action.
The lancet. Diabetes & endocrinology. 9(9):553-555 [DOI] 10.1016/S2213-8587(21)00181-9. [PMID] 34339632.
2021
Delayed diagnosis of diabetic ketoacidosis and associated mortality during the COVID-19 pandemic.
Journal of diabetes. 13(10):837-839 [DOI] 10.1111/1753-0407.13208. [PMID] 34196115.
2021
Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes?
The lancet. Diabetes & endocrinology. 9(6):328-329 [DOI] 10.1016/S2213-8587(21)00087-5. [PMID] 33838106.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size
Diabetes. 70(4):944-954 [DOI] 10.2337/db20-0995. [PMID] 33441381.
2021
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature genetics. 53(7):962-971 [DOI] 10.1038/s41588-021-00880-5. [PMID] 34127860.
2021
geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq
Genome Biology. 22(1) [DOI] 10.1186/s13059-021-02548-z. [PMID] 34872616.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes. 70(4):932-943 [DOI] 10.2337/db20-0937. [PMID] 33419759.
2021
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. 118(41) [DOI] 10.1073/pnas.2107208118. [PMID] 34611019.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas
The American Journal of Pathology. 191(3):454-462 [DOI] 10.1016/j.ajpath.2020.11.010. [PMID] 33307036.
2021
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study.
Science immunology. 6(62) [DOI] 10.1126/sciimmunol.abf3733. [PMID] 34376480.
2021
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia. 64(4):836-844 [DOI] 10.1007/s00125-020-05365-4. [PMID] 33496819.
2021
Insulin Receptor–Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice
The Journal of Immunology. 206(7):1443-1453 [DOI] 10.4049/jimmunol.1900357. [PMID] 33658296.
2021
Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology. 22(1) [DOI] 10.1186/s13059-021-02262-w. [PMID] 33478573.
2021
Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation.
Cell reports. 34(5) [DOI] 10.1016/j.celrep.2021.108725. [PMID] 33535031.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-85659-8. [PMID] 33753784.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Diabetes. 70(5):1123-1129 [DOI] 10.2337/db20-1103. [PMID] 33632742.
2021
Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes.
Diabetes. 70(2):313-322 [DOI] 10.2337/dbi20-0026. [PMID] 33472941.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
Diabetes. 70(8):1885-1897 [DOI] 10.2337/db21-0070. [PMID] 34035041.
2021
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices.
Journal of visualized experiments : JoVE. (170) [DOI] 10.3791/62207. [PMID] 33900291.
2021
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950). 207(3):849-859 [DOI] 10.4049/jimmunol.2000708. [PMID] 34301848.
2021
Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes.
Diabetologia. 64(8):1822-1833 [DOI] 10.1007/s00125-021-05468-6. [PMID] 34003304.
2021
Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.622647. [PMID] 33841327.
2021
Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry.
Cell reports. 37(5) [DOI] 10.1016/j.celrep.2021.109919. [PMID] 34731614.
2021
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.778912. [PMID] 34912300.
2021
Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes.
Metabolomics : Official journal of the Metabolomic Society. 17(11) [DOI] 10.1007/s11306-021-01850-y. [PMID] 34775536.
2021
TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.
Cell. 184(3):827-839.e14 [DOI] 10.1016/j.cell.2020.11.035. [PMID] 33545036.
2021
The influence of selection bias on identifying an association between allergy medication use and SARS-CoV-2 infection.
EClinicalMedicine. 37 [DOI] 10.1016/j.eclinm.2021.100936. [PMID] 34104879.
2021
The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence.
Diabetes. 70(8):1623-1633 [DOI] 10.2337/db21-0052. [PMID] 35381061.
2021
The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence.
Diabetes. 70(8):1623-1633 [DOI] 10.2337/db21-0052. [PMID] 35381061.
2021
The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence
Diabetes Care. 44(8):1734-1743 [DOI] 10.2337/dci21-0015.
2021
Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts.
Diabetes care. 44(10):2329-2336 [DOI] 10.2337/dc21-0226. [PMID] 34362815.
2021
Voices: Insulin and beyond.
Cell metabolism. 33(4):692-699 [DOI] 10.1016/j.cmet.2021.03.017. [PMID] 33826910.
2020
An Intolerable Burden: Suicide, Intended Self-Injury and Diabetes.
Canadian journal of diabetes. 44(6):541-544 [DOI] 10.1016/j.jcjd.2020.01.008. [PMID] 32305294.
2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.02180. [PMID] 33013915.
2020
Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.
Diabetes Care. 43(6):1360-1362 [DOI] 10.2337/dc19-1941. [PMID] 32273273.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics. 22(12):948-953 [DOI] 10.1089/dia.2020.0305. [PMID] 32833543.
2020
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.
Metabolites. 10(9) [DOI] 10.3390/metabo10090350. [PMID] 32867274.
2020
Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals.
Diabetes, obesity & metabolism. 22(6):997-1000 [DOI] 10.1111/dom.13982. [PMID] 32003110.
2020
Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention. Diabetes Care 2019;42:2228-2236.
Diabetes care. 43(4) [DOI] 10.2337/dc20-er04. [PMID] 32132004.
2020
Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds.
Canine medicine and genetics. 7(1) [DOI] 10.1186/s40575-020-00089-5. [PMID] 33323126.
2020
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 26(12):1505-1513 [DOI] 10.4158/EP-2020-0295. [PMID] 33471743.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism. 32(6):1041-1051.e6 [DOI] 10.1016/j.cmet.2020.11.005. [PMID] 33207244.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association. 37(12):2160-2168 [DOI] 10.1111/dme.14361. [PMID] 32634859.
2020
Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.574447. [PMID] 33193362.
2020
Innate inflammation drives NK cell activation to impair Treg activity
Journal of Autoimmunity. 108 [DOI] 10.1016/j.jaut.2020.102417. [PMID] 32035746.
2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis
Diabetes. 69(3):413-423 [DOI] 10.2337/db19-0942. [PMID] 31826866.
2020
Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.01103. [PMID] 32582188.
2020
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care. 43(1):5-12 [DOI] 10.2337/dc19-0880. [PMID] 31753960.
2020
Large-scale electron microscopy database for human type 1 diabetes.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-16287-5. [PMID] 32424134.
2020
Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Nature Communications. 11(1) [DOI] 10.1038/s41467-020-17040-8. [PMID] 32601271.
2020
Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.
JCI insight. 5(14) [DOI] 10.1172/jci.insight.136579. [PMID] 32573495.
2020
Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.
JAMA pediatrics. 174(6):609-617 [DOI] 10.1001/jamapediatrics.2020.0085. [PMID] 32202626.
2020
Organisation of the human pancreas in health and in diabetes
Diabetologia. 63(10):1966-1973 [DOI] 10.1007/s00125-020-05203-7. [PMID] 32894306.
2020
Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis.
JCI insight. 5(8) [DOI] 10.1172/jci.insight.134525. [PMID] 32324170.
2020
Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease.
Patterns (New York, N.Y.). 1(8) [DOI] 10.1016/j.patter.2020.100120. [PMID] 33294866.
2020
Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Nature Communications. 11(1) [DOI] 10.1038/s41467-020-17574-x. [PMID] 32699243.
2020
Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
Angewandte Chemie. 132(50):22773-22779 [DOI] 10.1002/ange.202008847.
2020
Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues
Angewandte Chemie International Edition. 59(50):22584-22590 [DOI] 10.1002/anie.202008847.
2020
Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.
The Journal of clinical endocrinology and metabolism. 105(5):1629-40 [DOI] 10.1210/clinem/dgz296. [PMID] 31867614.
2020
Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis
Scientific Reports. 10(1) [DOI] 10.1038/s41598-019-56951-5. [PMID] 31959869.
2020
Teaching Type 1 Diabetes: Creating Stakeholder Engagement in Biomedical Careers Through Undergraduate Research Curriculum
Medical Science Educator. 30(1):69-73 [DOI] 10.1007/s40670-019-00877-0. [PMID] 34457640.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues
Diabetes. 69(1):60-66 [DOI] 10.2337/db19-0554. [PMID] 31597639.
2020
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Diabetologia. 63(3):588-596 [DOI] 10.1007/s00125-019-05047-w. [PMID] 31768570.
2019
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.
Cell metabolism. 29(3):755-768.e5 [DOI] 10.1016/j.cmet.2018.11.014. [PMID] 30713109.
2019
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.
Analytical chemistry. 91(9):5794-5801 [DOI] 10.1021/acs.analchem.9b00024. [PMID] 30843680.
2019
Bringing closure: towards achieving a better understanding of Israel.
Lancet (London, England). 394(10198) [DOI] 10.1016/S0140-6736(19)31760-X. [PMID] 31376991.
2019
Clinical features, biochemistry and HLA-DRB1 status in children and adolescents with diabetes in Dhaka, Bangladesh
Diabetes Research and Clinical Practice. 158 [DOI] 10.1016/j.diabres.2019.107894. [PMID] 31669629.
2019
Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan
Diabetes Research and Clinical Practice. 149:9-17 [DOI] 10.1016/j.diabres.2019.01.023. [PMID] 30710658.
2019
Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering. 5(5):2631-2646 [DOI] 10.1021/acsbiomaterials.9b00332. [PMID] 31119191.
2019
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
Nature Communications. 10(1) [DOI] 10.1038/s41467-019-11460-x. [PMID] 31399563.
2019
Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-38905-z. [PMID] 30862859.
2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports. 29(10):3073-3086.e5 [DOI] 10.1016/j.celrep.2019.11.010. [PMID] 31801074.
2019
Islet amyloidosis in a child with type 1 diabetes
Islets. 11(2):44-49 [DOI] 10.1080/19382014.2019.1599707. [PMID] 31084520.
2019
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes
Journal of Histochemistry & Cytochemistry. 67(1):41-52 [DOI] 10.1369/0022155418778546. [PMID] 29771178.
2019
Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].
Diabetologia. 62(6):1100-1103 [DOI] 10.1007/s00125-019-4873-6. [PMID] 31016358.
2019
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
Diabetes. 68(6):1267-1276 [DOI] 10.2337/db19-0057. [PMID] 30967424.
2019
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.
Cell metabolism. 29(3):769-783.e4 [DOI] 10.1016/j.cmet.2019.01.003. [PMID] 30713110.
2019
NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).
Diabetes. 68(7):1394-1402 [DOI] 10.2337/db19-0058. [PMID] 31127054.
2019
Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity. 26(4):188-194 [DOI] 10.1097/MED.0000000000000484. [PMID] 31145130.
2019
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Diabetologia. 62(5):744-753 [DOI] 10.1007/s00125-019-4811-7. [PMID] 30675626.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine. 8(9) [DOI] 10.3390/jcm8091321. [PMID] 31466263.
2019
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
Diabetes Care. 42(2):281-287 [DOI] 10.2337/dc18-1512. [PMID] 30552130.
2019
Research digest: pioneering an oral GLP-1 receptor agonist.
The lancet. Diabetes & endocrinology. 7(12) [DOI] 10.1016/S2213-8587(19)30360-2. [PMID] 31748168.
2019
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Cell Metabolism. 29(5):1045-1060.e10 [DOI] 10.1016/j.cmet.2019.01.021. [PMID] 30799288.
2019
The challenge of modulating β-cell autoimmunity in type 1 diabetes.
The lancet. Diabetes & endocrinology. 7(1):52-64 [DOI] 10.1016/S2213-8587(18)30112-8. [PMID] 30528099.
2019
The challenge of modulating β-cell autoimmunity in type 1 diabetes.
The lancet. Diabetes & endocrinology. 7(1):52-64 [DOI] 10.1016/S2213-8587(18)30112-8. [PMID] 30528099.
2019
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program.
Nature. 574(7777):187-192 [DOI] 10.1038/s41586-019-1629-x. [PMID] 31597973.
2019
The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.
Diabetes care. 42(8):1357-1364 [DOI] 10.2337/dc19-0102. [PMID] 31167894.
2019
Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.
Diabetes care. 42(3):406-415 [DOI] 10.2337/dc18-1727. [PMID] 30659077.
2019
Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.
Metabolomics : Official journal of the Metabolomic Society. 15(2) [DOI] 10.1007/s11306-019-1477-6. [PMID] 30830416.
2019
Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention.
Diabetes care. 42(12):2228-2236 [DOI] 10.2337/dc19-0593. [PMID] 31558546.
2018
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
Cell Reports. 22(10):2667-2676 [DOI] 10.1016/j.celrep.2018.02.032. [PMID] 29514095.
2018
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Diabetes care. 41(9):1887-1894 [DOI] 10.2337/dc18-0087. [PMID] 30002199.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-22574-5. [PMID] 29540798.
2018
Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.
Frontiers in endocrinology. 9 [DOI] 10.3389/fendo.2018.00791. [PMID] 30687234.
2018
Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: incidence, clinical features, biochemistry, and HLA-DRB1 status.
Diabetes Research and Clinical Practice. 144:252-259 [DOI] 10.1016/j.diabres.2018.09.009. [PMID] 30218742.
2018
Hospital time prior to death and pancreas histopathology: implications for future studies.
Diabetologia. 61(4):954-958 [DOI] 10.1007/s00125-017-4494-x. [PMID] 29128936.
2018
Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.
Diabetes. 67(10):2038-2053 [DOI] 10.2337/db17-1227. [PMID] 30065030.
2018
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles
Diabetes. 67(4):697-703 [DOI] 10.2337/db17-0937. [PMID] 29343548.
2018
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.
Diabetes care. 41(9):1917-1925 [DOI] 10.2337/dc18-0494. [PMID] 30012675.
2018
Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.
The Journal of clinical investigation. 128(5):1888-1902 [DOI] 10.1172/JCI97739. [PMID] 29438107.
2018
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of
Chemical science. 9(34):6944-6951 [DOI] 10.1039/c8sc02680g. [PMID] 30210768.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism. 103(1):35-45 [DOI] 10.1210/jc.2017-01159. [PMID] 28938416.
2018
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01053. [PMID] 29868014.
2018
Remnant β Cells in Recent-Onset Type 1 Diabetes Have Essentially Normal Gene Expression and Function, but α Cells are Significantly Compromised
.
2018
Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes—The TrialNet Experience
Diabetes. 67(7):1216-1225 [DOI] 10.2337/db18-0065. [PMID] 29769238.
2018
Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.
Diabetes care. 41(12):2480-2486 [DOI] 10.2337/dc18-0861. [PMID] 30275285.
2018
Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes
Diabetes Care. 41(4):653-661 [DOI] 10.2337/dc17-0806. [PMID] 29559451.
2017
β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?
Nature reviews. Endocrinology. 13(9) [DOI] 10.1038/nrendo.2017.83. [PMID] 28685769.
2017
Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.
JAMA pediatrics. 171(12):1217-1225 [DOI] 10.1001/jamapediatrics.2017.2905. [PMID] 29052687.
2017
Beta cell mass versus function in type 1 diabetes: truth or dare?
.
2017
Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?
Diabetes. 66(6):1443-1452 [DOI] 10.2337/db16-1551. [PMID] 28533295.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 23(8) [DOI] 10.1038/nm0817-1004a. [PMID] 28777787.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 23(2) [DOI] 10.1038/nm0217-264a. [PMID] 28170374.
2017
Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.
Genome research. 27(11):1807-1815 [DOI] 10.1101/gr.217984.116. [PMID] 29025893.
2017
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials
Diabetes Care. 40(11):1494-1499 [DOI] 10.2337/dc17-0916. [PMID] 28860125.
2017
Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy.
Molecular therapy. Methods & clinical development. 4:178-191 [DOI] 10.1016/j.omtm.2016.12.003. [PMID] 28345003.
2017
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas. 46(2):252-259 [DOI] 10.1097/MPA.0000000000000717. [PMID] 27984510.
2017
Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 198(11):4255-4267 [DOI] 10.4049/jimmunol.1700024. [PMID] 28461573.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes
Diabetes Care. 40(9):e122-e123 [DOI] 10.2337/dc17-0996.
2017
Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes.
BMC genomics. 18(1) [DOI] 10.1186/s12864-017-3949-2. [PMID] 28821222.
2017
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
Diabetes. 66(3):722-734 [DOI] 10.2337/db16-1025. [PMID] 27920090.
2017
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00655. [PMID] 28659913.
2017
Mary Tyler Moore (1936-2017): Diabetes Educator and Advocate.
Diabetes care. 40(6):732-735 [DOI] 10.2337/dci17-0015. [PMID] 28533256.
2017
More on Intralymphatic Injection of Autoantigen in Type 1 Diabetes.
The New England journal of medicine. 377(4) [DOI] 10.1056/NEJMc1703468. [PMID] 28748691.
2017
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Cell metabolism. 26(3):568-575.e3 [DOI] 10.1016/j.cmet.2017.08.013. [PMID] 28877460.
2017
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.
Scientific reports. 7 [DOI] 10.1038/srep42372. [PMID] 28205558.
2017
Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.
Proceedings of the National Academy of Sciences of the United States of America. 114(38):10196-10201 [DOI] 10.1073/pnas.1711169114. [PMID] 28874568.
2017
Raising Awareness: The Need to Promote Allocation of Pancreata From Rare Nondiabetic Donors With Pancreatic Islet Autoimmunity to Type 1 Diabetes Research.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(1):306-307 [DOI] 10.1111/ajt.13983. [PMID] 27460917.
2017
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Diabetologia. 60(4):753-755 [DOI] 10.1007/s00125-016-4195-x. [PMID] 28070616.
2017
Re-addressing the 2013 consensus guidelines for the diagnosis of insulits in human type 1 diabetes – Is change necessary?
. 60(4):753-755
2017
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.
Diabetologia. 60(1):35-38 [PMID] 27785529.
2017
Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334–1345
Diabetes. 66(9):e10-e11 [DOI] 10.2337/dbi17-0029. [PMID] 28830918.
2017
Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care. 40(4):577-582 [DOI] 10.2337/dc16-1774. [PMID] 28115475.
2017
T cells display mitochondria hyperpolarization in human type 1 diabetes.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-11056-9. [PMID] 28883439.
2017
Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays
Journal of Proteome Research. 16(1):195-203 [DOI] 10.1021/acs.jproteome.6b00354.
2017
Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy
The Journal of Immunology. 199(11):3757-3770 [DOI] 10.4049/jimmunol.1700822. [PMID] 29055002.
2017
Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway
Diabetes. 66(12):3061-3071 [DOI] 10.2337/db17-0106. [PMID] 28877912.
2017
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-09908-5. [PMID] 28842637.
2016
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.
Diabetes. 65(5):1310-6 [DOI] 10.2337/db15-0492. [PMID] 26718498.
2016
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.
Human pathology. 56:93-100 [DOI] 10.1016/j.humpath.2016.06.006. [PMID] 27342911.
2016
An Interview with Dr. Mark Atkinson on 100 Years of Type 1 Diabetes Care and Research
Endocrinology. 157(11):4087-4090
2016
Analysis of Self-Antigen Specificity of Islet Infiltrating T Cells from Human Donors with Type 1 Diabetes
. 22(12):1482-1487
2016
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine. 22(12):1482-1487 [DOI] 10.1038/nm.4203. [PMID] 27798614.
2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes. 65(12):3765-3775 [PMID] 27669730.
2016
Autoimmune manifestations in aged mice arise from early-life immune dysregulation.
Science translational medicine. 8(361) [PMID] 27798262.
2016
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(2):983-93 [DOI] 10.1096/fj.15-279810. [PMID] 26546129.
2016
Factors impeding the discovery of an intervention-based treatment for type 1 diabetes.
Clinical and experimental immunology. 183(1):1-7 [DOI] 10.1111/cei.12656. [PMID] 25989477.
2016
Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics. 18 Suppl 1:S69-75 [DOI] 10.1089/dia.2016.2507. [PMID] 26836431.
2016
Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
Diabetes. 65(1):285-296 [DOI] 10.2337/db15-0179. [PMID] 26450993.
2016
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes. 65(3):719-31 [DOI] 10.2337/db15-0779. [PMID] 26581594.
2016
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
Diabetologia. 59(11):2448-2458 [DOI] 10.1007/s00125-016-4067-4. [PMID] 27506584.
2016
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.
Clinical and experimental immunology. 183(3):350-7 [DOI] 10.1111/cei.12731. [PMID] 26462724.
2016
Pancreatic and Ductal Cell Hyperplasia/Dysplasia with Obstructive Chronic Pancreatitis: An Association with Reduced Pancreatic Weight in Type 1 Diabetes. Reply to Kobayashi T., Aida K., Fukui T. et al [letter] and Saisho Y. [letter]
. 59(4):865-867
2016
Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].
Diabetologia. 59(4):870-2 [DOI] 10.1007/s00125-016-3889-4. [PMID] 26861059.
2016
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care. 39(7):1292-4 [DOI] 10.2337/dc16-0737. [PMID] 27330131.
2016
Sulfatide preserves insulin crystals not by being integrated in the lattice but by stabilizing their surface
. 2016
2016
Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.
Journal of diabetes research. 2016 [DOI] 10.1155/2016/6179635. [PMID] 26981544.
2016
The influence of type 1 diabetes on pancreatic weight.
Diabetologia. 59(1):217-221 [DOI] 10.1007/s00125-015-3752-z. [PMID] 26358584.
2016
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
JCI insight. 1(20) [DOI] 10.1172/jci.insight.88242. [PMID] 27942583.
2016
Towards a Functional Hypothesis Relating Anti-Islet Autoimmunity to the Dietary Impact on Microbial Communities and Butyrate Production
. 26(4)
2016
Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production.
Microbiome. 4 [DOI] 10.1186/s40168-016-0163-4. [PMID] 27114075.
2016
Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.
Proteomics. 16(9):1432-46 [DOI] 10.1002/pmic.201500333. [PMID] 26935967.
2016
Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.
Diabetes. 65(11):3233-3239 [PMID] 27959859.
2016
Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease.
Clinical and experimental immunology. 185(1):33-41 [DOI] 10.1111/cei.12797. [PMID] 27029857.
2015
A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
Clinical immunology (Orlando, Fla.). 160(1):90-102 [DOI] 10.1016/j.clim.2015.03.023. [PMID] 25842187.
2015
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
Scientific reports. 5 [DOI] 10.1038/srep13155. [PMID] 26279095.
2015
A Friend or Foe?
. S
2015
A run on the biobank: what have we learned about type 1 diabetes from the nPOD tissue repository?
Current opinion in endocrinology, diabetes, and obesity. 22(4):290-5 [DOI] 10.1097/MED.0000000000000171. [PMID] 26087339.
2015
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
Diabetes. 64(11):3885-90 [DOI] 10.2337/db15-0449. [PMID] 26216853.
2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation. 125(1):448-55 [DOI] 10.1172/JCI78492. [PMID] 25500887.
2015
Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes.
Endocrine. 49(3):693-702 [DOI] 10.1007/s12020-015-0534-9. [PMID] 25605478.
2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes. 64(11):3873-84 [DOI] 10.2337/db15-0164. [PMID] 26185279.
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-Prone Bi-Congenic B6.NODC11bxC1tb Mice
. 7:5-17
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
2015
Current concepts on the pathogenesis of type 1 diabetes–considerations for attempts to prevent and reverse the disease.
Diabetes care. 38(6):979-88 [DOI] 10.2337/dc15-0144. [PMID] 25998290.
2015
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.
Journal of immunology (Baltimore, Md. : 1950). 195(1):145-55 [DOI] 10.4049/jimmunol.1402381. [PMID] 25994968.
2015
Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.
Diabetes care. 38(2):329-32 [DOI] 10.2337/dc14-0850. [PMID] 25519450.
2015
Hla-Associated Susceptibility To Type 1 Diabetes in the Developing World Reveals Differences Among Populations; Implications for Prediction and Intervention
Tissue Antigens. 85(5)
2015
Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.
American journal of medical genetics. Part A. 167A(1):69-79 [DOI] 10.1002/ajmg.a.36810. [PMID] 25355237.
2015
Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.
PloS one. 10(11) [DOI] 10.1371/journal.pone.0142318. [PMID] 26580221.
2015
Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced Cd40(+) B Cells To Maintain Tolerance To Islet Autoantigens
Diabetes. 64(1):158-171 [DOI] 10.2337/db13-1639. [PMID] 25187361.
2015
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Diabetes care. 38(10):1964-74 [DOI] 10.2337/dc15-1419. [PMID] 26404926.
2015
Study of Gaba in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
Frontiers in pharmacology. 6 [DOI] 10.3389/fphar.2015.00260. [PMID] 26617516.
2015
The role for gut permeability in the pathogenesis of type 1 diabetes–a solid or leaky concept?
Pediatric diabetes. 16(7):485-92 [DOI] 10.1111/pedi.12305. [PMID] 26269193.
2015
The streetlight effect in type 1 diabetes.
Diabetes. 64(4):1081-90 [DOI] 10.2337/db14-1208. [PMID] 25805758.
2015
Type 1 Diabetes: Around the World With Hla
Human Immunology. 76(4)
2014
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.
Frontiers in microbiology. 5 [DOI] 10.3389/fmicb.2014.00678. [PMID] 25540641.
2014
Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.
Journal of materials chemistry. B. 2(17):2562-2574 [PMID] 24778809.
2014
Compromised Gut Microbiota Networks in Children with Anti-Islet Autoimmunity
Diabetes. 63(6):2006-2014
2014
Compromised gut microbiota networks in children with anti-islet cell autoimmunity
Diabetes. 63(6):2006-14 [DOI] 10.2337/db13-1676. [PMID] 24608442.
2014
Effect of a Single Autologous Cord Blood Infusion On Beta-Cell and Immune Function in Children With New Onset Type 1 Diabetes: a Non-Randomized, Controlled Trial
Pediatric Diabetes. 15(2):100-109 [DOI] 10.1111/pedi.12072. [PMID] 24102806.
2014
Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas
. 57(2):392-401
2014
Gaba Promotes Human Beta-Cell Proliferation and Modulates Glucose Homeostasis
Diabetes. 63(12):4197-4205 [DOI] 10.2337/db14-0153. [PMID] 25008178.
2014
Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950). 193(3):1024-34 [DOI] 10.4049/jimmunol.1303230. [PMID] 24973447.
2014
Losing a grip on the notion of β-cell specificity for immune responses in type 1 diabetes: can we handle the truth?
Diabetes. 63(11):3572-4 [DOI] 10.2337/db14-1069. [PMID] 25342726.
2014
Mechanisms of Pdl1-Mediated Regulation of Autoimmune Diabetes (Vol 125, Pg 16, 2007)
Clinical Immunology. 150(1) [DOI] 10.1016/j.clim.2013.09.004.
2014
Nardilysin-Dependent Proteolysis of Cell-Associated Vtcn1 (B7-H4) Marks Type 1 Diabetes Development
Diabetes. 63(10):3470-3482 [DOI] 10.2337/db14-0213. [PMID] 24848066.
2014
New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
Current diabetes reports. 14(10) [DOI] 10.1007/s11892-014-0530-0. [PMID] 25142715.
2014
Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.
Diabetes. 63(8):2876-87 [DOI] 10.2337/db13-1236. [PMID] 24677716.
2014
Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora’s box.
Diabetologia. 57(4):656-9 [DOI] 10.1007/s00125-013-3159-7. [PMID] 24442510.
2014
Pancreatic Biopsies in Type 1 Diabetes: Revisiting the Myth of Pandora’s Box
. 57:656-659
2014
Stem cells to insulin secreting cells: two steps forward and now a time to pause?
Cell stem cell. 15(5):535-6 [DOI] 10.1016/j.stem.2014.10.012. [PMID] 25517460.
2014
The intestinal microbiome in type 1 diabetes.
Clinical and experimental immunology. 177(1):30-7 [DOI] 10.1111/cei.12321. [PMID] 24628412.
2014
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes. 15(1):1-9 [DOI] 10.1111/pedi.12097. [PMID] 24325575.
2014
Truncated Cables1 causes agenesis of the corpus callosum in mice.
Laboratory investigation; a journal of technical methods and pathology. 94(3):321-30 [DOI] 10.1038/labinvest.2013.146. [PMID] 24336072.
2014
Type 1 diabetes.
Lancet (London, England). 383(9911):69-82 [DOI] 10.1016/S0140-6736(13)60591-7. [PMID] 23890997.
2013
A Vision of Hope
Lancet. 382
2013
Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years–a population-based electronic cohort study.
PloS one. 8(11) [DOI] 10.1371/journal.pone.0079803. [PMID] 24236160.
2013
Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(7):1126-9 [DOI] 10.1016/j.bbmt.2013.04.011. [PMID] 23611977.
2013
Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes.
American journal of translational research. 5(2):184-99 [PMID] 23573363.
2013
George S. Eisenbarth, 1947-2012.
Diabetologia. 56(3):435-8 [DOI] 10.1007/s00125-013-2833-0. [PMID] 23354126.
2013
Global reality of type 1 diabetes care in 2013.
Diabetes care. 36(9) [DOI] 10.2337/dc13-0744. [PMID] 23970723.
2013
Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.
Cancer immunology, immunotherapy : CII. 62(4):737-46 [DOI] 10.1007/s00262-012-1380-8. [PMID] 23223899.
2013
Improving diabetes care in resource-poor countries: challenges and opportunities.
The lancet. Diabetes & endocrinology. 1(4):268-70 [DOI] 10.1016/S2213-8587(13)70172-4. [PMID] 24622408.
2013
Increased complement activation in human type 1 diabetes pancreata.
Diabetes care. 36(11):3815-7 [DOI] 10.2337/dc13-0203. [PMID] 24041678.
2013
Influence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes.
Immunogenetics. 65(1):83-90 [DOI] 10.1007/s00251-012-0659-4. [PMID] 23081744.
2013
Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.
Diabetes. 62(8):2870-8 [DOI] 10.2337/db12-1619. [PMID] 23835340.
2013
Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors
Diabetes. 62(7):2595-2604 [DOI] 10.2337/db12-1686. [PMID] 23524641.
2013
Nardilysin-Dependent Proteolysis of Cell-Associated Vtcn1: a Novel Pathway and Biomarker of Type 1 Diabetes Development
Journal of Immunology. 190
2013
Novel Detection of Pancreatic and Duodenal Homeobox 1 Autoantibodies (Paa) in Human Sera Using Luciferase Immunoprecipitation Systems (Lips) Assay
International Journal of Clinical and Experimental Pathology. 6:1202-1210
2013
Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076919. [PMID] 24204704.
2013
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials.
Diabetes. 62(1):9-17 [DOI] 10.2337/db12-0562. [PMID] 23258904.
2013
Reponse To Comments On: Butler Et Al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604
Diabetes. 62(10):E19-E22 [DOI] 10.2337/db13-0996. [PMID] 24065800.
2013
Serological Autoantibody Profiling of Type 1 Diabetes By Protein Arrays
Journal of Proteomics. 94:486-496 [DOI] 10.1016/j.jprot.2013.10.018. [PMID] 24148850.
2013
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes.
The Journal of experimental medicine. 210(1):191-203 [DOI] 10.1084/jem.20111843. [PMID] 23277452.
2013
The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
Journal of autoimmunity. 44:8-12 [DOI] 10.1016/j.jaut.2013.06.001. [PMID] 23891168.
2013
The diagnosis of insulitis in human type 1 diabetes.
Diabetologia. 56(11):2541-3 [DOI] 10.1007/s00125-013-3043-5. [PMID] 24006089.
2013
The Effects of Inpatient Hybrid Closed-loop Therapy Initiated Within 1 Week of Type 1 Diabetes Diagnosis
Diabetes Technology & Therapeutics. 15:401-408
2013
The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus.
Arthritis research & therapy. 15(2) [DOI] 10.1186/ar4208. [PMID] 23566364.
2013
Transient B-Cell Depletion With Anti-Cd20 in Combination With Proinsulin Dna Vaccine Or Oral Insulin: Immunologic Effects and Efficacy in Nod Mice
PLoS One. 8(2) [DOI] 10.1371/journal.pone.0054712. [PMID] 23405091.
2013
Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13(8):1963-75 [DOI] 10.1111/ajt.12333. [PMID] 23834659.
2013
Trying to make a difference for those with Type 1 Diabetes: a lesson in patience as well as a willingness to fail mightily
. 8(4):323-327
2013
Trying to make a difference for those with Type 1 diabetes: a lesson in patience as well as a willingness to fail mightily.
Expert review of endocrinology & metabolism. 8(4):323-327 [DOI] 10.1586/17446651.2013.811869. [PMID] 30736146.
2013
γ-Aminobutyric acid regulates both the survival and replication of human β-cells.
Diabetes. 62(11):3760-5 [DOI] 10.2337/db13-0931. [PMID] 23995958.
2012
Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
Blood. 120
2012
Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
BMC immunology. 13 [DOI] 10.1186/1471-2172-13-70. [PMID] 23237483.
2012
Central role for interleukin-2 in type 1 diabetes.
Diabetes. 61(1):14-22 [DOI] 10.2337/db11-1213. [PMID] 22187370.
2012
Collection protocol for human pancreas.
Journal of visualized experiments : JoVE. (63) [DOI] 10.3791/4039. [PMID] 22665046.
2012
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.
The Journal of experimental medicine. 209(1):51-60 [DOI] 10.1084/jem.20111187. [PMID] 22213807.
2012
Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease.
Diabetologia. 55(11):2868-77 [DOI] 10.1007/s00125-012-2672-4. [PMID] 22875196.
2012
Formation of a human β-cell population within pancreatic islets is set early in life.
The Journal of clinical endocrinology and metabolism. 97(9):3197-206 [DOI] 10.1210/jc.2012-1206. [PMID] 22745242.
2012
In Vitro Generation of Functional Insulin-Producing Cells from Human Bone Marrow-Derived Stem Cells, but Long-Term Culture Running Risk of Malignant Transformation
. 1:114-127
2012
In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.
American journal of stem cells. 1(2):114-127 [PMID] 22833839.
2012
Mixed Chimerism and Growth Factors Augment Beta Cell Regeneration and Reverse Late-Stage Type 1 Diabetes
Science Translational Medicine. 4(133) [DOI] 10.1126/scitranslmed.3003835. [PMID] 22572882.
2012
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews. 28(7):608-17 [DOI] 10.1002/dmrr.2316. [PMID] 22585677.
2012
No increased rate of acute myocardial infarction or stroke among patients with ankylosing spondylitis-a retrospective cohort study using routine data.
Seminars in arthritis and rheumatism. 42(2):140-5 [DOI] 10.1016/j.semarthrit.2012.02.008. [PMID] 22494565.
2012
On the Road To the Insulin Centenary
Lancet. 380
2012
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA. 308(22):2337-9 [DOI] 10.1001/jama.2012.15008. [PMID] 23232891.
2012
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
The Journal of clinical investigation. 122(5):1717-25 [DOI] 10.1172/JCI60530. [PMID] 22484814.
2012
Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.
Oncology letters. 4(4):840-846 [PMID] 23205111.
2012
The pathogenesis and natural history of type 1 diabetes.
Cold Spring Harbor perspectives in medicine. 2(11) [DOI] 10.1101/cshperspect.a007641. [PMID] 23125199.
2012
The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
PloS one. 7(5) [DOI] 10.1371/journal.pone.0036079. [PMID] 22615750.
2012
Tyrphostin Ag490 Agent Modestly But Significantly Prevents Onset of Type 1 in Nod Mouse; Implication of Immunologic and Metabolic Effects of a Jak-Stat Pathway Inhibitor
Journal of Clinical Immunology. 32(5):1038-1047 [DOI] 10.1007/s10875-012-9707-y. [PMID] 22661285.
2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine. 9 [DOI] 10.1186/1479-5876-9-21. [PMID] 21345239.
2011
Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.
Diabetes care. 34(12):2567-9 [DOI] 10.2337/dc11-1406. [PMID] 22011412.
2011
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine. 208(8):1673-82 [DOI] 10.1084/jem.20101715. [PMID] 21746813.
2011
Combinatorial treatment of bone marrow stem cells and stromal cell-derived factor 1 improves glycemia and insulin production in diabetic mice.
Molecular and cellular endocrinology. 345(1-2):88-96 [DOI] 10.1016/j.mce.2011.07.024. [PMID] 21801807.
2011
Evaluating preclinical efficacy.
Science translational medicine. 3(96) [DOI] 10.1126/scitranslmed.3002757. [PMID] 21849661.
2011
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
PloS one. 6(10) [DOI] 10.1371/journal.pone.0025792. [PMID] 22043294.
2011
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.
Diabetes. 60(5):1370-9 [DOI] 10.2337/db10-1797. [PMID] 21525508.
2011
Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.
Pancreas. 40(7):1147-9 [DOI] 10.1097/MPA.0b013e31821ffabe. [PMID] 21926555.
2011
Immune Modulation in Early Onset Pompe Disease
Molecular Genetics and Metabolism. 102(2):S31-S32 [DOI] 10.1016/j.ymgme.2010.11.107.
2011
Induction of Mixed Chimerism With Mhc-Mismatched But Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in Nod Mice
Diabetes. 60(2):555-564 [DOI] 10.2337/db10-0827. [PMID] 21270266.
2011
Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950). 186(6):3538-46 [DOI] 10.4049/jimmunol.1001864. [PMID] 21317395.
2011
It’s time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes.
Diabetes. 60(2):361-3 [DOI] 10.2337/db10-1506. [PMID] 21270247.
2011
It’s time to mow the GRAS in type 1 diabetes.
Diabetes. 60(11):2669-71 [DOI] 10.2337/db11-1158. [PMID] 22025772.
2011
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
Diabetes. 60(11):2914-21 [DOI] 10.2337/db11-0705. [PMID] 21926271.
2011
Mesenchymal Stem Cells Express Serine Protease Inhibitor To Evade the Host Immune Response
Blood. 117(4):1176-1183 [DOI] 10.1182/blood-2010-06-287979. [PMID] 21076046.
2011
Microbiology of Type 1 Diabetes: Possible Implications for Management of the Disease
. 1:325-331
2011
Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.
Diabetes. 60(5):1383-92 [DOI] 10.2337/db10-0907. [PMID] 21441442.
2011
Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes.
Diabetes. 60(3):693-4 [DOI] 10.2337/db10-1810. [PMID] 21357468.
2011
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes. 60(8):2086-91 [DOI] 10.2337/db11-0373. [PMID] 21659497.
2011
Rapamycin Combined With Anti-Cd45Rb Mab and Il-10 Or With G-Csf Induces Tolerance in a Stringent Mouse Model of Islet Transplantation
PLoS One. 6(12) [DOI] 10.1371/journal.pone.0028434. [PMID] 22174806.
2011
Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
Diabetes. 60(10):2566-70 [DOI] 10.2337/db11-0576. [PMID] 21844098.
2011
Stem Cell Therapy of Diabetes: Effective Treatment with Stromal Cell-Derived Factor 1 plus Bone Marrow Stem Cells in the Liver of Diabetic Mice
Molecular and Cellular Endocrinology. 345:88-96
2011
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950). 187(11):5921-30 [DOI] 10.4049/jimmunol.1100746. [PMID] 22043012.
2011
The Novel Role of Serpinb9 in Cytotoxic Protection of Human Mesenchymal Stem Cells
Journal of Immunology. 187(5):2252-2260 [DOI] 10.4049/jimmunol.1003981. [PMID] 21795594.
2011
The pancreas in human type 1 diabetes.
Seminars in immunopathology. 33(1):29-43 [DOI] 10.1007/s00281-010-0208-x. [PMID] 20495921.
2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Diabetologia. 54(9):2232-6 [DOI] 10.1007/s00125-011-2244-z. [PMID] 21773685.
2011
Toward Defining the Autoimmune Microbiome for Type 1 Diabetes
. 5(1):82-91
2011
Toward defining the autoimmune microbiome for type 1 diabetes.
The ISME journal. 5(1):82-91 [DOI] 10.1038/ismej.2010.92. [PMID] 20613793.
2010
A model for studying the impact of nurture on nature: Development of diabetes in multicongenic mice with an epigenetic gene expression dysregulation defect from the nonobese diabetic mouse (NOD)
Journal of Immunology. 175(7):4561-4565
2010
A Novel Clinically Relevant Strategy To Abrogate Autoimmunity and Regulate Alloimmunity in Nod Mice
Diabetes. 59(9):2253-2264 [DOI] 10.2337/db09-1264. [PMID] 20805386.
2010
Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant
Diabetes. 59(2):433-439 [DOI] 10.2337/db09-1168. [PMID] 19934002.
2010
Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition. 51(4):414-7 [DOI] 10.1097/MPG.0b013e3181dd913a. [PMID] 20706153.
2010
Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes
Diabetes. 59(12):3139-3147 [DOI] 10.2337/db10-0542. [PMID] 20841611.
2010
Developing Combination Immunotherapies for Type 1 Diabetes: Recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
Clinical and Experimental Immunology. 160(2):176-184
2010
Dimorphic Histopathology of Long Standing Childhood Onset Diabetes
. 53:1811-1812
2010
Dimorphic histopathology of long-standing childhood-onset diabetes.
Diabetologia. 53(4):690-8 [DOI] 10.1007/s00125-009-1642-y. [PMID] 20062967.
2010
Efforts to prevent and halt autoimmune beta cell destruction.
Endocrinology and metabolism clinics of North America. 39(3):527-39 [DOI] 10.1016/j.ecl.2010.05.006. [PMID] 20723818.
2010
Estimating the Cost of Type 1 Diabetes in the Us: a Propensity Score Matching Method
PLoS One. 5(7) [DOI] 10.1371/journal.pone.0011501. [PMID] 20634976.
2010
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications. 24(3):163-7 [DOI] 10.1016/j.jdiacomp.2008.12.004. [PMID] 19217320.
2010
Genetic Control of B-Cell Mass Homeostasis
. 4:11-24
2010
Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25).
Digestive diseases and sciences. 55(2):484-95 [DOI] 10.1007/s10620-009-0955-5. [PMID] 19714465.
2010
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
PloS one. 5(7) [DOI] 10.1371/journal.pone.0011726. [PMID] 20668510.
2010
Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver Or Pancreas To Reverse Refractory Autoimmune Diabetes
Diabetes. 59(9):2228-2236 [DOI] 10.2337/db10-0450. [PMID] 20530743.
2010
Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Disease
Diabetes. 59:2228-2236
2010
Influence of Serum and CD25 Stability on Regulatory T cell Activity: Implications for Immune Regulation
PLoS One. 4
2010
Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma.
Scandinavian journal of immunology. 72(4):293-301 [DOI] 10.1111/j.1365-3083.2010.02427.x. [PMID] 20883314.
2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia. 53(10):2198-204 [DOI] 10.1007/s00125-010-1829-2. [PMID] 20593162.
2010
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one. 5(5) [DOI] 10.1371/journal.pone.0010507. [PMID] 20463897.
2010
The Juvenile Diabetes Research Foundation at forty: updates of research in type 1 diabetes.
Diabetes. 59(7):1575-7 [DOI] 10.2337/db10-0622. [PMID] 20587801.
2010
The Type 1 Diabetes PhysioLab® Platform: A Validated Physiologically Based Mathematical Model of Pathogenesis in the Non-Obese Diabetic Mouse
Clinical and Experimental Immunology. 161:250-267
2010
Type I diabetes. Preface.
Endocrinology and metabolism clinics of North America. 39(3):xvii-xviii [DOI] 10.1016/j.ecl.2010.05.012. [PMID] 20723814.
2009
Amelioration of Insulitis and Reversal of Diabetes in Nod Mice By Murine Anti-Thymocyte Globulin and Granulocyte-Colony Stimulating Factor Combination Therapy
Clinical Immunology. 131:S48-S49 [DOI] 10.1016/j.clim.2009.03.137.
2009
Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation. 9
2009
Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
Diabetes care. 32(11):2041-6 [DOI] 10.2337/dc09-0967. [PMID] 19875605.
2009
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal. 3(5):536-48 [DOI] 10.1038/ismej.2009.5. [PMID] 19225551.
2009
Deaf1 Isoforms Control the Expression of Genes Encoding Peripheral Tissue Antigens in the Pancreatic Lymph Nodes During Type 1 Diabetes
Nature Immunology. 10(9):1026-U107 [DOI] 10.1038/ni.1773. [PMID] 19668219.
2009
Diabetic eNOS Knockout Mice Develop Accelerated Retinopathy
Investigative Ophthalmology & Visual Science. 50(13)
2009
Expansion of human regulatory T-cells from patients with type 1 diabetes.
Diabetes. 58(3):652-62 [DOI] 10.2337/db08-1168. [PMID] 19074986.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes. 58(10):2277-84 [DOI] 10.2337/db09-0557. [PMID] 19628781.
2009
Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes
Journal of Immunology. 183(2):993-1004 [DOI] 10.4049/jimmunol.0900803. [PMID] 19561093.
2009
Influence of Fecal Sample Storage on Bacterial Community Diversity
. 3:40-46
2009
Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal. 3:40-6 [DOI] 10.2174/1874285800903010040. [PMID] 19440250.
2009
Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one. 4(11) [DOI] 10.1371/journal.pone.0007980. [PMID] 19956753.
2009
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology. 174(4):1221-9 [DOI] 10.2353/ajpath.2009.080605. [PMID] 19246639.
2009
Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.
Pediatric research. 65(3):311-6 [DOI] 10.1203/PDR.0b013e3181961e80. [PMID] 19047917.
2009
Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research. 72:156-157
2009
Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia. 52(2):262-70 [DOI] 10.1007/s00125-008-1200-z. [PMID] 19002428.
2009
Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells.
Journal of thrombosis and haemostasis : JTH. 7(9):1523-32 [DOI] 10.1111/j.1538-7836.2009.03548.x. [PMID] 19583824.
2009
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950). 182(8):4608-15 [DOI] 10.4049/jimmunol.0713269. [PMID] 19342635.
2009
Rapamycin Prevents and Breaks the Anti-Cd3-Induced Tolerance in Nod Mice
Diabetes. 58(4):875-881 [DOI] 10.2337/db08-1432. [PMID] 19151201.
2009
T regulatory cell function in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany). 24(9):1691-8 [DOI] 10.1007/s00467-009-1214-x. [PMID] 19495805.
2009
Taking a daily vitamin to prevent type 1 diabetes?
Diabetes. 58(1):24-5 [DOI] 10.2337/db08-1479. [PMID] 19114727.
2009
The pancreas in human type 1 diabetes: providing new answers to age-old questions.
Current opinion in endocrinology, diabetes, and obesity. 16(4):279-85 [DOI] 10.1097/MED.0b013e32832e06ba. [PMID] 19502978.
2009
The road not taken: a path to curing type 1 diabetes?
European journal of immunology. 39(8):2054-8 [DOI] 10.1002/eji.200939517. [PMID] 19672902.
2009
Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment.
Diabetes care. 32(11):1977-9 [DOI] 10.2337/dc09-1089. [PMID] 19675194.
2008
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.). 126(3):303-14 [PMID] 18096436.
2008
A Prophylactic Protocol for the Prevention of Inhibitor Formation in Gene Therapy for Hemophilia B By Shifting the Balance From An Effector To a Regulatory T Cell Response
Blood. 112
2008
Addressing ceiling effects in health status measures: a comparison of techniques applied to measures for people with HIV disease.
Health services research. 43(1 Pt 1):327-39 [DOI] 10.1111/j.1475-6773.2007.00745.x. [PMID] 18211533.
2008
Alpha-1 antitrypsin treatment of spontaneously diabetic nonobese diabetic mice receiving islet allografts.
Transplantation proceedings. 40(2):457-8 [DOI] 10.1016/j.transproceed.2008.02.010. [PMID] 18374100.
2008
Autologous umbilical cord blood infusion for type 1 diabetes.
Experimental hematology. 36(6):710-5 [DOI] 10.1016/j.exphem.2008.01.009. [PMID] 18358588.
2008
CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
Cytokine. 44(1):154-9 [DOI] 10.1016/j.cyto.2008.07.468. [PMID] 18778952.
2008
Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic Nod Mice
Diabetes. 57(12):3281-3288 [DOI] 10.2337/db08-0688. [PMID] 18835930.
2008
Comparative analysis of the islet proteome between NOD/Lt and ALR/Lt mice.
Annals of the New York Academy of Sciences. 1150:68-71 [DOI] 10.1196/annals.1447.002. [PMID] 19120270.
2008
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences. 1150:152-6 [DOI] 10.1196/annals.1447.049. [PMID] 19120286.
2008
Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology. 154(1):15-21 [DOI] 10.1111/j.1365-2249.2008.03721.x. [PMID] 18759852.
2008
Immunomodulation By Mesenchymal Stem Cells – a Potential Therapeutic Strategy for Type 1 Diabetes
Diabetes. 57(7):1759-1767 [DOI] 10.2337/db08-0180. [PMID] 18586907.
2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes. 57(2):405-14 [PMID] 18039815.
2008
Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research. 63(3):303-7 [PMID] 18091354.
2008
Prolonged islet allograft survival by alpha-1 antitrypsin: the role of humoral immunity.
Transplantation proceedings. 40(2):455-6 [DOI] 10.1016/j.transproceed.2008.02.009. [PMID] 18374099.
2008
Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.
Diabetes. 57(3):757-69 [PMID] 18086901.
2008
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
The American journal of pathology. 173(1):154-60 [DOI] 10.2353/ajpath.2008.070963. [PMID] 18511516.
2008
The “perfect storm” for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.
Diabetes. 57(10):2555-62 [DOI] 10.2337/db08-0331. [PMID] 18820210.
2008
The IDS Conducts Standardization of Assays for the Measurement of Autoantibodies and of T Cells in Autoimmune Diabetes
. 1150
2008
The IDS conducts standardization of assays for the measurement of autoantibodies and of T cells in autoimmune diabetes. Preface.
Annals of the New York Academy of Sciences. 1150 [DOI] 10.1196/annals.1447.066. [PMID] 19120260.
2008
The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology. 88(9):949-61 [DOI] 10.1038/labinvest.2008.60. [PMID] 18607348.
2007
Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7(5):1112-20 [PMID] 17456199.
2007
Alpha-1 antitrypsin treatment of spontaneously diabetic NOD mice receiving islet allografts
Xenotransplantation. 14(5):497-498
2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes. 56(5):1316-23 [PMID] 17360983.
2007
Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?
. 50(1):220-221
2007
Assessing the in Vitro Suppressive Capacity of Regulatory T Cells
. 36:607-628
2007
Assessing the in vitro suppressive capacity of regulatory T cells.
Immunological investigations. 36(5-6):607-28 [PMID] 18161521.
2007
Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11.
Immunology. 122(1):1-14 [PMID] 17662044.
2007
Comment on: Brugman S et al. (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49:2105-2108.
Diabetologia. 50(1):220-1 [PMID] 17119915.
2007
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Annals of the New York Academy of Sciences. 1103:90-3 [PMID] 17376822.
2007
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
Journal of the American Society of Nephrology : JASN. 18(2):539-50 [PMID] 17202420.
2007
Elimination of Insulitis and Augmentation of Islet β Cell Regeneration Via Induction of Chimerism in Overtly Diabetic NOD Mice
Proceedings of the National Academy of Sciences. 104:2337-2342
2007
Large-Scale Genetic Fine Mapping and Genotype-Phenotype Associations Implicate Polymorphism in the IL2RA Region in Type 1 Diabetes
Nature Genetics. 39:1074-1082
2007
Mechanisms of PDL1-Mediated Regulation of Autoimmune Diabetes
. 125:16-25
2007
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
The Journal of experimental medicine. 204(6):1463-74 [PMID] 17548519.
2007
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
Diabetes. 56(3):604-12 [PMID] 17327427.
2007
Novel synthesis of cerium oxide nanoparticles for free radical scavenging.
Nanomedicine (London, England). 2(3):325-32 [PMID] 17716177.
2007
The Virtual NOD Mouse: Applying Predictive Biosimulation to Research in Type 1 Diabetes
. 1103:45-62
2007
The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes.
Annals of the New York Academy of Sciences. 1103:45-62 [PMID] 17376834.
2007
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood. 110(10):3673-81 [PMID] 17690255.
2007
Treg in Type 1 Diabetes
. 48(2-3):165-175
2007
Treg in type 1 diabetes.
Cell biochemistry and biophysics. 48(2-3):165-75 [PMID] 17709886.
2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy. 17(6):625-34 [PMID] 16776571.
2006
Antibiotic Treatment Partially Protects Against Type 1 Diabetes in the Bio-Breeding Diabetes-Prone Rat. Is the Gut Flora Involved in the Development of Type-1 Diabetes?
. 49:2105-2108
2006
Autoantibody markers for the diagnosis and prediction of type 1 diabetes.
Autoimmunity reviews. 5(6):424-8 [PMID] 16890898.
2006
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes. 55(7):1939-45 [PMID] 16804061.
2006
Efficient Delivery of siRNA into Cytokine-Stimulated Insulinoma Cells Silences Fas Expression and Inhibits Fas-Mediated Apoptosis
. 580:553-560
2006
Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis.
FEBS letters. 580(2):553-60 [PMID] 16412430.
2006
Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.
Laboratory investigation; a journal of technical methods and pathology. 86(2):130-40 [PMID] 16424881.
2006
Freeze-Thaw Increases Adeno-Associated Virus Transduction of Cells
American Journal of Physiology-Cell Physiology. 291:386-392
2006
IL-10 regulation of lupus in the NZM2410 murine model.
Laboratory investigation; a journal of technical methods and pathology. 86(11):1136-48 [PMID] 16924244.
2006
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 177(11):7943-9 [PMID] 17114466.
2006
Long-term Monitoring of Transplanted Islets Using Positron Emission Tomography
. 14:851-856
2006
Long-term monitoring of transplanted islets using positron emission tomography.
Molecular therapy : the journal of the American Society of Gene Therapy. 14(6):851-6 [PMID] 16982215.
2006
Measurements of asbestos burden in tissues.
Annals of the New York Academy of Sciences. 1076:281-91 [PMID] 17119209.
2006
Noninvasive imaging of islet grafts using positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America. 103(30):11294-9 [PMID] 16868090.
2006
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Diabetes. 55(1):171-8 [PMID] 16380490.
2006
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).
Gene. 369:134-41 [PMID] 16412588.
2006
Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation.
Laboratory investigation; a journal of technical methods and pathology. 86(8):829-41 [PMID] 16732298.
2006
Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy.
Journal of the American Society of Nephrology : JASN. 17(3):736-45 [PMID] 16436494.
2005
9th Annual EASD/JDRF Oxford Workshop Mechanisms and Prevention of Type 1 Diabetes
.
2005
A comprehensive review of interventions in the NOD mouse and implications for translation.
Immunity. 23(2):115-26 [PMID] 16111631.
2005
ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can’t we prevent or reverse this disease?
Diabetes. 54(5):1253-63 [PMID] 15855308.
2005
An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells
Journal of Immunology. 5181-6 [DOI] 10.4049/jimmunol.174.9.5181. [PMID] 15843512.
2005
An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950). 174(9):5181-6 [PMID] 15843512.
2005
Autoimmunity to Glutamic Acid Decarboxylase in the Neurodegenerative Disorder Batten Disease
. 64:743-745
2005
Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice.
Brain research. 1041(2):223-30 [PMID] 15829231.
2005
Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of pediatric gastroenterology and nutrition. 40(5):589-95 [PMID] 15861021.
2005
Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Two Children with Type 1 Diabetes Mellitus
Pediatric Diabetes. 6:244-248
2005
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology. 79(2):1045-52 [PMID] 15613333.
2005
Donor CD8+ T Cells Facilitate Induction of Chimerism and Tolerance Without GVHD in Autoimmune NOD Mice Conditioned with Anti-CD3 mAb
Blood. 105:2180-2188
2005
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy. 16(2):235-47 [PMID] 15761263.
2005
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes. 54(5):1407-14 [PMID] 15855327.
2005
Gene Therapy for Prevention and Treatment of Type 1 Diabetes
Laboratory Techniques in Biochemistry and Molecular Biology. 31:125-159
2005
Glucose Transporter-2 (GLUT2) Promoter Mediated Transgenic Insulin Production Reduces Hyperglycemia in Diabetic Mice
. 579:5759-5764
2005
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.
FEBS letters. 579(25):5759-64 [PMID] 16223491.
2005
High Frequency of Abnormal Glucose Tolerance in DQA1*02/DQB1*0602 Relatives Identified as Part of the Diabetes Prevention Trial–Type 1 Diabetes
. 48:68-74
2005
IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.
Journal of the American Society of Nephrology : JASN. 16(12):3651-60 [PMID] 16251240.
2005
Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II.
Human gene therapy. 16(1):68-80 [PMID] 15703490.
2005
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America. 102(20):7251-6 [PMID] 15878989.
2005
Islet cell autoantibodies: a case of a premature obituary.
Pediatric diabetes. 6(4):181-3 [PMID] 16390385.
2005
Lessons from attempts to prevent type 1 diabetes—potential implications for type 2 diabetes
. 27(4):338-344
2005
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(3):519-27 [PMID] 15979413.
2005
Neonatal Nutritional Interventions in the Prevention of Type 1 Diabetes
. 6:220-226
2005
Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of immunology (Baltimore, Md. : 1950). 175(7):4561-5 [PMID] 16177100.
2005
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis.
Diabetes. 54(9):2525-32 [PMID] 16123339.
2005
Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?
Diabetologia. 48(11):2200-2 [PMID] 16193285.
2005
SUMO Wrestling with Type 1 Diabetes
Molecular Therapy. 83:504-513
2005
SUMO wrestling with type 1 diabetes.
Journal of molecular medicine (Berlin, Germany). 83(7):504-13 [PMID] 15806321.
2005
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect eveidence for islet regeneration? Commentary
. 48(11):2221-2218
2005
Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
Transplantation. 80(4):530-3 [PMID] 16123729.
2005
Type 1 diabetes mellitus: etiology, presentation, and management.
Pediatric clinics of North America. 52(6):1553-78 [PMID] 16301083.
2005
Viruses and Diabetes-Reply
Diabetic Medicine. 22(7)
2004
A Functional Variant of SUM04, a New I Kappa B Alpha Modifier, is Associated with Type 1 Diabetes
Nature Genetics. 36:937-841
2004
A Piece of Nucleic Acid Surrounded By Controversy: Coxsackieviruses and the Causes of Type 1 Diabetes
Diabetic Medicine. 21:503-506
2004
Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes.
Diabetes care. 27(8):2010-4 [PMID] 15277432.
2004
Animal Models Have Little to Teach Us About Type 1 Diabetes
. 47:1650-1656
2004
Assessing the quality of immunoassay systems: Radioimmunoassays and enzyme, fluorescence, and luminescence immunoassays; approved guideline
. 23-27
2004
Bioluminescent Monitoring of Islet Graft Survival After Transplantation
. 9:428-435
2004
Bioluminescent monitoring of islet graft survival after transplantation.
Molecular therapy : the journal of the American Society of Gene Therapy. 9(3):428-35 [PMID] 15006610.
2004
Evaluation of the size and type of free particulates collected from unused asbestos-containing brake components as related to potential for respirability.
American journal of industrial medicine. 46(6):545-53 [PMID] 15551364.
2004
Gene Therapy for Type 1 Diabetes: Metabolism, Immunity, Islet Cell Preservation and Regeneration
. 11:91-97
2004
Glutamic Acid Decarboxylase Autoimmunity in Batten Disease and Other Disorders
. 14:2001-2005
2004
Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.
Neurology. 63(11):2001-5 [PMID] 15596740.
2004
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology. 165(3):1045-53 [PMID] 15331427.
2004
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Gene therapy. 11(3):233-40 [PMID] 14737082.
2004
In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.
Diabetes. 53(7):1721-32 [PMID] 15220196.
2004
Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific IL-10-Dependent Regulatory T Cells in Naïve Non-Obese Diabetic Mice
Journal of Immunology. 173:6777-6785
2004
Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus–a new surrogate measure of non-progression?
Pediatric diabetes. 5(2):72-9 [PMID] 15189492.
2004
Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.
Diabetes Care. 27(12):2911-7 [DOI] 10.2337/diacare.27.12.2911. [PMID] 15562206.
2004
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
Gene therapy. 11(2):181-6 [PMID] 14712302.
2004
Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes.
Nature reviews. Immunology. 4(12):989-97 [DOI] 10.1038/nri1502. [PMID] 15573133.
2004
Timing of initial cereal exposure in infancy and risk of islet autoimmunity.
The Journal of pediatrics. 144(5):684-5 [PMID] 15152374.
2004
Von-Herrath.: Satisfaction (Not) Guaranteed: Re-evaluating the Use of Animal Models of Type-1 Diabetes
. 4:989-997
2003
Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
Pediatric diabetes. 4(1):10-8 [PMID] 14655518.
2003
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes. 52(3):708-16 [PMID] 12606512.
2003
Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
Journal of the American Society of Nephrology : JASN. 14(4):947-58 [PMID] 12660329.
2003
Glucose-Responsive Expression of the Human Insuin Promoter in HEP G2 Human Hepatoma Cells
. 1005:237-241
2003
Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells.
Annals of the New York Academy of Sciences. 1005:237-41 [PMID] 14679068.
2003
Infant diets and type 1 diabetes: too early, too late, or just too complicated?
JAMA. 290(13):1771-2 [PMID] 14519713.
2003
Infant Diets and Type 1 Diabetes: Too Early, Too Late, or Just Too Complicated?
. 290:1771-1772
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950). 171(5):2270-8 [PMID] 12928371.
2003
Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver.
Gene therapy. 10(18):1551-8 [PMID] 12907946.
2003
The Second Murine Autoantibody Workshop: Remarkable Inter-laboratory Concordance for Radiobinding Assays to Identify Insulin Autoantibodies in Non-Obese Diabetic Mice
. 1005:1-12
2003
The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice.
Annals of the New York Academy of Sciences. 1005:1-12 [PMID] 14679035.
2003
Type 1 diabetes alters anti-hsp90 autoantibody isotype.
Journal of autoimmunity. 20(3):237-45 [PMID] 12753809.
2003
Why can’t we prevent type 1 diabetes?: maybe it’s time to try a different combination.
Diabetes care. 26(12):3326-8 [PMID] 14633822.
2002
Adeno-Associated Virus Transduction of Islets with Interleukin-4 Results in Impaired Metabolic Function in Syngeneic Marginal Islet Mass Transplantation
Transplantation. 74:1184-1186
2002
Fatal attraction: chemokines and type 1 diabetes.
The Journal of clinical investigation. 110(11):1611-3 [PMID] 12464665.
2002
Heat Shock Protein Therapy Fails to Prevent Diabetes in NOD Mice
. 45:1350-1351
2002
Heat shock protein therapy fails to prevent diabetes in NOD mice.
Diabetologia. 45(9):1350-1 [PMID] 12242470.
2002
International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: Analyzing Target Autoantigens of Humoral Immunity in Non-Obese Diabetic Mice
Annals of the New York Academy of Sciences. 958:1-2
2002
Transduction of Human and mouse Pancreatic Islet Cells Using a Bicistronic Recombinant Adeno-Associated Viral Vector
Molecular Therapy. 5:154-160
2001
A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950). 166(11):6925-36 [PMID] 11359854.
2001
Adeno-Associated Virus (AAV) as a Vehicle for Therapeutic Gene Delivery: Improvements in Vector Design and Viral Production Enhance Potential to Prolong Graft Survival in Pancreatic Islet Cell Transplantation for the Reversal of Type 1 Diabetes
. 1:245-258
2001
Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery: improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes.
Current molecular medicine. 1(2):245-58 [PMID] 11899074.
2001
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America. 98(24):13913-8 [PMID] 11717448.
2001
Characterization of Preparations of Glutamic Acid Decarboxylase-65, Proinsulin and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T Cells in Type 1 Diabetes Mellitus. Report of Phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T cell Assays in Type 1 Diabetes Mellitus
Diabetes. 50:1749-1754
2001
Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.
Diabetes. 50(3):515-20 [PMID] 11246870.
2001
Ingested IFN-Alpha Preserves Residual Beta Cell Function in Type 1 Diabetes
. 21:1021-1031
2001
International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: Identification of Insulin but not Glutamic Acid Decarboxylase or IA-2 as Specific Autoantigens of Humoral Autoimmunity in Nonobese Diabetic Mice
Diabetes. 50:2451-2458
2001
Prediction of Diabetes and Response to Therapy in Individual Animals: Are There Lessons for Man?
Journal of Autoimmunity. 16:15-19
2001
Proposed Guidelines on Screening for Risk of Type 1 Diabetes
Diabetes Care. 24
2001
Type 1 diabetes: new perspectives on disease pathogenesis and treatment.
Lancet. 358(9277):221-9 [DOI] 10.1016/S0140-6736(01)05415-0. [PMID] 11476858.
2000
Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.
Diabetes. 49(5):708-11 [PMID] 10905477.
2000
Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus.
Scandinavian journal of immunology. 51(6):626-33 [PMID] 10849375.
2000
Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in Beta Cells
Science. 287:191-192
2000
Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations.
Pediatric diabetes. 1(1):10-6 [PMID] 15016237.
2000
T-cell markers in Type 1 Diabetes: Progress, Prospects and Realistic Expectations
. 43:819-820
2000
The $64000 question in diabetes continues.
Lancet (London, England). 356(9223):4-6 [PMID] 10892753.
1999
Autoantigens IA-2 and GAD in Type 1 (Insulin Dependent) Diabetes
. 42:3-14
1999
Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes.
Diabetologia. 42(1):3-14 [PMID] 10027571.
1999
Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays.
Journal of autoimmunity. 13(2):267-82 [PMID] 10479395.
1999
Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.
Diabetes. 48(2):299-303 [PMID] 10334305.
1999
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America. 96(14):8116-9 [PMID] 10393957.
1999
No Alteration in T Lymphocyte Expression of CD40 Ligand (CD154) in Individuals with or at Increased Risk for Insulin-Dependent Diabetes Mellitus
. 84:4068-4072
1999
No alteration in T lymphocyte expression of CD40 ligand (CD154) in individuals with or at increased risk for insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism. 84(11):4068-72 [PMID] 10566651.
1999
Selection of hprt Mutant T Cells as Surrogates for Dividing Cells Reveals a Restricted T Cell Receptor BV Repertoire in Insulin-Dependent Diabetes Mellitus
. 90:340-351
1999
Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus.
Clinical immunology (Orlando, Fla.). 90(3):340-51 [PMID] 10075863.
1999
The NOD Mouse Model of Type 1 Diabetes Mellitus: As Good As It Gets?
. 5:601-604
1999
The NOD mouse model of type 1 diabetes: as good as it gets?
Nature medicine. 5(6):601-4 [PMID] 10371488.
1998
Aging and the Immune Response to Tetanus Toxoid: Diminished Frequency and Level of Cellular Immune Reactivity to Antigenic Stimulation
. 5:894-896
1998
Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation.
Clinical and diagnostic laboratory immunology. 5(6):894-6 [PMID] 9801353.
1998
Cellular Immune Responses Against Casein: Elevated but not Specific for Individuals with Insulin Dependent Diabetes
. 41:731-735
1998
Cellular immune responses to beta casein: elevated in but not specific for individuals with Type I diabetes mellitus.
Diabetologia. 41(6):731-5 [PMID] 9662058.
1998
Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice.
Journal of autoimmunity. 11(1):83-95 [PMID] 9480726.
1998
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.
Nature. 391(6663):177-81 [PMID] 9428763.
1998
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors.
Proceedings of the National Academy of Sciences of the United States of America. 95(24):14384-8 [PMID] 9826709.
1998
The relationship between humoral and cellular immunity to IA-2 in IDDM.
Diabetes. 47(4):566-9 [PMID] 9568688.
1997
Antipolymer antibodies, silicone breast implants, and fibromyalgia.
Lancet (London, England). 349(9059) [PMID] 9113032.
1997
Cellular Immune Activities in Women with Silicone Breast Implants: A preliminary investigation
. 79:151-154
1997
Cellular immune reactivities in women with silicone breast implants: a preliminary investigation.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 79(2):151-4 [PMID] 9291420.
1997
Infants diets and insulin-dependent diabetes: evaluating the “cows’ milk hypothesis” and a role for anti-bovine serum albumin immunity.
Journal of the American College of Nutrition. 16(4):334-40 [PMID] 9263182.
1997
Insulin-Dependent Diabetes Mellitus: the Hypothesis of Molecular Mimicry Between Islet Cell Antigens and Microorganisms
Molecular Medicine. 3:76-83
1997
Mechanisms underlying the loss of self tolerance in NOD mice.
Research in immunology. 148(5):301-6 [PMID] 9352593.
1997
Mechanisms Underlying the Loss of Self-Tolerance in NOD Mice
. 148:301-306
1997
Molecular mimicry and the pathogenesis of insulin-dependent diabetes mellitus: still just an attractive hypothesis.
Annals of medicine. 29(5):393-9 [PMID] 9453286.
1997
NOD Mice as a Model for Inherited Deafness
. 40
1997
Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens.
Diabetes. 46(12):1975-82 [PMID] 9392483.
1997
The Effect of Superantigen Administration on the Natural History of IDD in NOD Mice
. 40:257-257
1997
The NOD mouse-Discussion
. 148(5):359-366
1997
The Role of Infant Nutrition in the Pathogenesis of Insulin Dependent Diabetes
Food Technology. 51:77-79
1996
Early infant diets and insulin-dependent diabetes.
Lancet (London, England). 347(9013):1464-5 [PMID] 8676633.
1996
Glutamic Acid Decarboxylase Autoantibodies in Stiff-Man Syndrome and Insulin Dependent Diabetes Mellitus Exhibit Similarities and Differences in Epitope Recognition
Journal of Immunology. 156:818-825
1996
Identification and characterization of glima 38, a glycosylated islet membrane antigen of 38KD, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes
Molecular Biology of the Cell. 7:3468-3468
1996
Identification and Characterization of Glima38, a Glycosylated Islet Cell Membrane Antigen, Which Together with GAD65 and IA2 Marks the Early Phases of Autoimmune Response inT 1 Diabetes
. 97:2772-2783
1996
Immunological and metabolic effects of prophylactic insulin therapy in the NOD-scid/scid adoptive transfer model of IDDM.
Diabetes. 45(2):205-8 [PMID] 8549866.
1996
Modulating Autoimmune Responses to GAD Inhibits Disease Progression and Prolongs Islet Graft Survival in Diabetes-Prone Mice
. 2:1348-1353
1996
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.
Nature medicine. 2(12):1348-53 [PMID] 8946834.
1996
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
The Journal of experimental medicine. 183(4):1561-7 [PMID] 8666914.
1996
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
The Journal of pharmacology and experimental therapeutics. 279(2):790-4 [PMID] 8930185.
1996
Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.
Journal of immunology (Baltimore, Md. : 1950). 157(3):1279-87 [PMID] 8757636.
1996
The Clinical Significance of an Autoimmune Response against Glutamic Acid Decarboxylase
. 2:148-153
1996
The clinical significance of an autoimmune response against glutamic acid decarboxylase.
Nature medicine. 2(2):148-53 [PMID] 8574952.
1995
Clonal Diversion of T Cell Responses from Th1 to Th2: A Possible Mechanism of Diabetes Resistance in NOD-Ead Transgenic Mice
Autoimmunity. 21:52-56
1995
Cow’s Milk and IDDM: Only Time Will Tell
. 9:1-2
1995
Detection of exocytosis at individual pancreatic beta cells by amperometry at a chemically modified microelectrode.
Proceedings of the National Academy of Sciences of the United States of America. 92(21):9608-12 [PMID] 7568182.
1994
Cellular Immunity to a Determinant Common to Glutamate Decarboxylase and Coxsackie Virus in Insulin Dependent Diabetes
. 94:2125-2129
1994
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.
The Journal of clinical investigation. 94(5):2125-9 [PMID] 7962558.
1994
GAD65 autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus.
Journal of autoimmunity. 7(6):865-72 [PMID] 7888042.
1994
Inverse Relation Between Humoral and Cellular Immunity to Glutamic Acid Decarboxylase in Subjects at Risk of Insulin-Dependent Diabetes
Journal of Endocrinological Investigation. 17:581-584
1994
Lack of Immunity to Bovine Serum Albumin in Insulin-Dependent Diabetes Mellitus. Authors Reply
New England Journal of Medicine. 330(22):1616-1617
1994
Prevention of Diabetes in the NOD Mouse: Implications for Therapeutic Intervention in Human Disease
. 15:115-120
1994
Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease.
Immunology today. 15(3):115-20 [PMID] 8172643.
1994
Should We Replace Islet Cell Antibody Assay For The Prediction of Insulin Dependent Diabetes
. 8:33-34
1994
The pathogenesis of insulin-dependent diabetes mellitus.
The New England journal of medicine. 331(21):1428-36 [PMID] 7969282.
1994
The thymus as a site for evaluating the potency of candidate beta cell autoantigens in NOD mice.
Journal of autoimmunity. 7(6):851-8 [PMID] 7888041.
1993
Amperometric monitoring of chemical secretions from individual pancreatic beta-cells.
Analytical chemistry. 65(14):1882-7 [PMID] 8368536.
1993
Amperometric Monitoring of individual Exocytosis events in pancreatic beta cells
Analytical chemistry. 65:1882-1887
1993
Association of 70 Kd molecule with HLA-DR of Rheumatic Fever Patients
ZENTRALBLATT FUR BAKTERIOLOGIE-SUPPLEMENT. 528-528
1993
Conformational Epitope Dependency for Islet Cell Cytoplasmic Autoantibodies (ICA) Reactive to Glutamate-Decarboxylase (GAD) in Insulin- Dependent Diabetes (IDD)
Diabetes. 42:A114-A114
1993
Early Diagnosis and Specific Treatment of Insulin-Dependent Diabetes
. 342
1993
Early Diagnosis and Specific Treatment of Insulin-Dependent Diabetes
. 696:342-350
1993
Early diagnosis and specific treatment of insulin-dependent diabetes.
Annals of the New York Academy of Sciences. 696:342-50 [PMID] 8109841.
1993
Inverse Relation Between Humoral and Cellular Immunity to Glutamic Acid Decarboxylase in Subjects at Risk of Insulin-Dependent Diabetes
Lancet. 341(8857):1365-1369
1993
Islet Cell Autoantigens in Insulin Dependent Diabetes
. 92:1608-1616
1993
Islet cell autoantigens in insulin-dependent diabetes.
The Journal of clinical investigation. 92(4):1608-16 [PMID] 8408615.
1993
Islet Cell Cytoplasmic Autoantibody Reactivity to Glutamate Decarboxylase in Insulin-Dependent Diabetes
. 91(1)
1993
Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.
The Journal of clinical investigation. 91(1):350-6 [PMID] 8423231.
1993
Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes.
The New England journal of medicine. 329(25):1853-8 [PMID] 8247037.
1993
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Nature. 366(6450):69-72 [PMID] 7694152.
1992
Autoimmunity to Two Forms of Glutamate Decarboxylase in Insulin Dependent Diabetes Mellitus
. 89:283-292
1992
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
The Journal of clinical investigation. 89(1):283-92 [PMID] 1370298.
1992
Is Insulin-Dependent Diabetes Mellitus Environmentally Induced?
New England Journal of Medicine. 327:348-349
1992
Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes.
Lancet (London, England). 339(8791):458-9 [PMID] 1346821.
1991
GAD Autoimmunity in IDDM
.
1991
No Evidence for Serological Autoimmunity To Islet Cell Heat Shock Proteins in Insulin Dependent Diabetes
. 87:721-724
1991
No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes.
The Journal of clinical investigation. 87(2):721-4 [PMID] 1991854.
1990
64,000 Mr autoantibodies as predictors of insulin-dependent diabetes.
Lancet (London, England). 335(8702):1357-60 [PMID] 1971659.
1990
Comparison of islet autoantibodies in ‘pre-diabetes’ and recommendations for screening.
Journal of autoimmunity. 3 Suppl 1:47-51 [PMID] 2187460.
1990
Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy.
Diabetes. 39(8):933-7 [PMID] 2197139.
1990
No Evidence for HSP 65 in Insulin Dependent Diabetes
Lancet. 336:1250-1251
1990
No Role for 65 kD Heat-Shock Protein in Diabetes
Lancet. 336(8725):1250-1251
1990
The natural history and predictive value of Mr 64,000 autoantibodies for insulin-dependent diabetes mellitus.
Journal of autoimmunity. 3 Suppl 1:41-5 [PMID] 2187459.
1990
What causes diabetes?
Scientific American. 263(1):62-3, 66 [PMID] 2197720.
1988
Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen.
Diabetes. 37(11):1587-90 [PMID] 3053305.
1988
Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats.
Autoimmunity. 2(1):11-9 [PMID] 3155150.
1988
Enzymatic activity and filament assembly of Acanthamoeba myosin II are regulated by adjacent domains at the end of the tail.
FEBS letters. 234(2):435-8 [PMID] 2968922.
1988
Inherited susceptibility to insulin-dependent diabetes is associated with HLA-DR1, while DR5 is protective.
Autoimmunity. 1(3):197-205 [PMID] 2979618.
1988
Insulin autoantibodies in pre-diabetes.
Advances in experimental medicine and biology. 246:45-51 [PMID] 3074667.
1987
Bovine Albumin Antibodies in NOD Mice
. 6:67-69
1987
Bovine albumin antibodies in NOD mice.
Diabetes research (Edinburgh, Scotland). 6(2):67-9 [PMID] 3427869.
1986
Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?
Diabetes. 35(8):894-8 [PMID] 3525287.
1986
Immune Response to Bovine Serum-Albumin (BSA) in NOD Mice – Possible Relevance to Diabetes
Diabetes. 35:A184-A184
1986
Insulin Autoantibodies As Markers For Insullin-Dependent Diabetes Mellitus (IDD)
Diabetes. 35:A87-A87
ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas
. [DOI] 10.1101/2020.08.31.270736.
Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice
. [DOI] 10.1101/2020.04.18.048272.
Pancreatlas™: applying an adaptable framework to map the human pancreas in health and disease
. [DOI] 10.1101/2020.03.27.006320.

Grants

Feb 2024 ACTIVE
EVALUATION OF NOVEL COMPOUNDS POTENTIALLY TARGETING CENTRAL SIGMA RECEPTORS REGARDING THEIR ABILITY TO LOWER BLOOD GLUCOSE IN DIABETIC MICE.
Role: Co-Project Director/Principal Investigator
Funding: ALCHEM LABORATORIES, INC
Oct 2023 ACTIVE
Network for Pancreatic Organ Donors – nPOD
Role: Principal Investigator
Funding: JDRF
Jun 2023 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2023 ACTIVE
Deciphering fatty acid metabolism in type 1 diabetes using imaging mass spectrometry
Role: Faculty
Funding: JDRF
Sep 2022 ACTIVE
Interdisciplinary Graduate Program in Type 1 Diabetes and Biomedical Engineering
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2022 ACTIVE
Biorepository and Coordinating Center for Studies on Cardiovascular Complications of Human Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2022 ACTIVE
Investigating type 1 diabetes pathogenesis using the live pancreas tissue slice platform.
Role: Other
Funding: NATL INST OF HLTH NIDDK
Feb 2022 ACTIVE
New way in delivering immunomodulatory drugs in T1D
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL via NATL INST OF HLTH NIAID
Sep 2021 ACTIVE
Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2021 ACTIVE
Experimental and natural SARS-CoV-2 infection of the human pancreas
Role: Principal Investigator
Funding: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI via NATL INST OF HLTH NIDDK
Aug 2021 ACTIVE
Human Pancreas Analysis Program (HPAP)
Role: Principal Investigator
Funding: UNIV OF PENNSYLVANIA via NATL INST OF HLTH NIDDK
May 2021 – Sep 2023
The Network for Pancreatic Organ donors with Diabetes (nPOD) : A Collaborative Type 1 Diabetes Research Project
Role: Principal Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Dec 2020 – Apr 2021
The George S. Eisenbarth nPOD Award for Team Science
Role: Principal Investigator
Funding: UNIV OF MIAMI via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Aug 2020 – Jul 2021
Targeted nanodelivery in T1D
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL via NATL INST OF HLTH NIAID
Aug 2020 ACTIVE
Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2020 ACTIVE
Regional and lobular heterogeneity of human pancreas morphology and function in type 1 diabetes pathogenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2020 ACTIVE
TrialNet Clinical Center infrastructure support services
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIDDK
Feb 2020 – Jan 2023
Human Atlas of Neonatal Developmental and Early Life Pancreas / Immunity (HANDEL)-P/I Continuation
Role: Principal Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Nov 2019 – Oct 2020
2020 nPOD Annual Meeting Conference Grant
Role: Principal Investigator
Funding: JDRF
Oct 2019 ACTIVE
Data Coordinating Center for Type 1 Diabetes TrialNet
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIDDK
Sep 2019 – Dec 2023
Human Pancreas Analysis Program-T2D
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER via NATL INST OF HLTH NIDDK
Sep 2019 ACTIVE
Evaluation of the safety, tolerability and general response to Lactobacillus johnsonii N6.2 in children and adolescents with T1D
Role: Project Manager
Funding: JDRF
Mar 2019 – Aug 2020
In situ characterization of human alpha cell physiology in type 1 diabetes pathogenesis
Role: Principal Investigator
Funding: HELMHOLTZ ZENTRUM MUNCHEN via JDRF
Jan 2019 – Jun 2022
Blanche J. Salisbury Diabetes Research Fund
Role: Principal Investigator
Funding: UF FOUNDATION
Dec 2018 – Aug 2022
Validating KIRAs as B cell-sparing drugs in islets from human patients with T1D
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Nov 2018 – Aug 2020
Neural regulation of alpha cell function and dysregulation in type 1 diabetes
Role: Co-Investigator
Funding: JDRF
Nov 2018 – Oct 2019
2019 nPOD Annual Meeting Conference Grant
Role: Principal Investigator
Funding: JDRF
Oct 2018 – Sep 2022
T cell receptor sequencing in type 1 diabetes – biomarker discovery and technology development
Role: Other
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Sep 2018 – Aug 2021
Identification of Anti-Neo-Antigen AutoAntibodies in Type 1 Diabetes
Role: Principal Investigator
Funding: ARIZONA STATE UNIVERSITY via NATL INST OF HLTH NIDDK
Sep 2018 – Jun 2023
A 3D Tissue Map of the Human Lymphatic System
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Aug 2018 – May 2020
Roles of the Insulin-like Growth Factor Axis in Pre-Type 1 Diabetes Immune Regulation
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jun 2018 – May 2023
Immune Function and the Progression to Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018 – Jun 2019
Characterization of T cell Autoreactivity in Type 1 Diabetes
Role: Other
Funding: JDRF
Apr 2018 – Mar 2022
B-lymphocyte targeting therapies for autoimmune diabetes
Role: Principal Investigator
Funding: THE JACKSON LABORATORY via NATL INST OF HLTH NIDDK
Apr 2018 – Sep 2023
Network for Pancreatic Organ Donors – nPOD
Role: Principal Investigator
Funding: JDRF
Jan 2018 – Sep 2023
Collaborative Type 1 Diabetes Research Project: The Network for Pancreatic Organ donors with Diabetes (nPOD)
Role: Principal Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2018 – Dec 2018
nPOD Annual Meeting Costs – 2018
Role: Principal Investigator
Funding: JDRF
Nov 2017 – Oct 2019
The JDRF nPOD Viral Work group: nPOD-V
Role: Principal Investigator
Funding: UNIV OF MIAMI via JDRF
Sep 2017 – Jun 2022
Data coordinating Center for Type 1 Diabetes TrialNet (UC4)
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIDDK
Sep 2017 – Aug 2022
Interdisciplinary Graduate Program in Type 1 Diabetes and Biomedical Engineering
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2017 – May 2020
A Novel Combination Therapy for Type 1 Diabetes Prevention
Role: Other
Funding: NATL INST OF HLTH NIDDK
Mar 2017 – Feb 2018
NIDDK Type 1 Diabetes TrialNet Data Coordinating Center
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIDDK
Feb 2017 – Jan 2020
Human Atlas of the Neonatal Development and Early Life Pancreas (Handel-P)
Role: Principal Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2017 – Dec 2017
nPOD Annual Meeting Costs – 2017 & 2018
Role: Principal Investigator
Funding: JDRF
Oct 2016 – Jun 2019
Serum protein biomarkers for predicting type 1 diabetes development
Role: Co-Investigator
Funding: PACIFIC NW NATL LAB via NATL INST OF HLTH NIDDK
Sep 2016 – Jul 2021
Integrated Program for Human Pancreas Procurement and Analysis
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER via NATL INST OF HLTH NIDDK
Jan 2016 – Dec 2017
Helmsley Trust Diabetes Cell Repository
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2016 – Dec 2016
Measuring markers and cytokines in human serum and plasma to determine phenotype and a genotype correlations in Type 1 Diabetes
Role: Principal Investigator
Funding: AMER DIABETES ASSOCIATION
Sep 2015 – May 2020
Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2015 – Feb 2017
NIDDK Type 1 diabetes trialnet data coordinating center
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH
Jan 2015 – Dec 2015
Helmsley Trust Diabetes Cell Repository
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jul 2014 – Jun 2019
Biomaterial Delivery System for Type 1 Diabetes Vaccine
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Jun 2014 – Apr 2020
TrialNet: University of Florida Clinical Center and Network
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
May 2013 – Jun 2018
Immune Function and the Progression to Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2013 – Mar 2018
B-lymphocyte Targeting Therapies for Autoimmune Diabetes
Role: Principal Investigator
Funding: THE JACKSON LABORATORY via NATL INST OF HLTH
Jan 2013 – Mar 2018
NPOD Coordinating Center
Role: Principal Investigator
Funding: JDRF
Sep 2012 – Aug 2016
The JDRF nPOD Viral Work Group: nPOD V
Role: Principal Investigator
Funding: JDRF
Jul 2012 – Jun 2017
Assessment of cytokines in human islets from patients with type 1 diabetes
Role: Principal Investigator
Funding: LA JOLLA INST FOR ALLERGY & IMMUNOLOGY via NATL INST OF HLTH NIAID
Jul 2012 – Jun 2016
Identifying the contribution of beta cell dysfunction and autoimmunity to the pathogenesis of type 1 diabetes
Role: Principal Investigator
Funding: AMER DIABETES ASSOCIATION

Education

Director
2016-2020 · University of Florida Diabetes Institute
American Diabetes Association Eminent Scholar for Diabetes Research
2007-2020 · University of Florida
Eminent Scholar
2007-2020 · University of Florida
Jeffrey Keene Family Professor
2004-2020 · University of Florida
Co-Director
2000-2014 · Diabetes Center of Excellence
Sebastian Family Professor for Diabetes Research
1998-2007 · University of Florida
Director
1998-2006 · The Center for Immunology and Transplantation
Associate Professor / Tenure
1994-1999 · Department of Pathology, University of Florida
Assistant Professor
1990-1994 · Department of Pathology, University of Florida
Post-Doctoral Associate
1988-1990 · Department of Pathology, University of Florida
Hagedorn Research Laboratory
1986 · Gentofte, Denmark
Ph.D., Department of Pathology
1984-1988 · University of Florida
Hershey Medical Center
1983-1984 · Pennsylvania State University
B.S., Microbiology
1979-1983 · University of Michigan-Dearborn

Contact Details

Phones:
Business:
(352) 273-8278
Emails:
Business:
atkinson@ufl.edu
Addresses:
Business Mailing:
BMSB J593
GAINESVILLE FL 32611