Martha Campbell-Thompson,
Professor
About Martha Campbell-Thompson
Martha Campbell-Thompson, D.V.M., Ph.D, serves as the Molecular Pathology Core Principal Investigator at the University of Florida, where she earned doctorates in veterinary medicine and veterinary physiology. A board certified large animal veterinary surgeon, Dr. Campbell-Thompson moved into basic research after receiving her Ph.D. She has over 20 years experience in animal models of human disease with an emphasis on type 1 diabetes.
Related Links:
Accomplishments
nPOD Founding Investigator Award
2018
·
JDRF
Graduate research award
1988
·
University of Florida, Charles F. Simpson Memorial Scholarship
Graduate Research Award
1987
·
Comparative Gastroenterology Society
Graduate Student Award
1987
·
Comparative Gastroenterology Society
Fellow
1986
·
American College of Veterinary Surgeons
Large Animal Resident of the Year
1984
·
University of Florida College of Veterinary Medicine
Large Animal Resident of the Year
1983
·
University of Florida College of Veterinary Medicine
Teaching Profile
Courses Taught
2018
GMS7980 Research for Doctoral Dissertation
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-6878-1235
Areas of Interest
- Beta cell biology
- Beta cell regeneration for Type 1 Diabetes
- Islet inflammation
- Neuromodulation of beta cell function
Publications
2023
Disease progression joint model predicts time to type 1 diabetes onset: Optimizing future type 1 diabetes prevention studies.
CPT: pharmacometrics & systems pharmacology.
[DOI] 10.1002/psp4.12973.
[PMID] 37186151.
2023
Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448.
Diabetes.
[DOI] 10.2337/db23-er08.
[PMID] 37116182.
2023
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Diabetes.
72(4):433-448
[DOI] 10.2337/db22-0942.
[PMID] 36940317.
2022
Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.
Pancreas.
51(6):586-592
[DOI] 10.1097/MPA.0000000000002080.
[PMID] 36206463.
2022
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Pancreas.
51(9):1061-1073
[DOI] 10.1097/MPA.0000000000002170.
[PMID] 37078927.
2022
Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia.
Cell death discovery.
8(1)
[DOI] 10.1038/s41420-022-01165-4.
[PMID] 36055991.
2022
Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium.
Pancreas.
51(6):593-597
[DOI] 10.1097/MPA.0000000000002077.
[PMID] 36206464.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes.
70(4):944-954
[DOI] 10.2337/db20-0995.
[PMID] 33441381.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas
The American Journal of Pathology.
191(3):454-462
[DOI] 10.1016/j.ajpath.2020.11.010.
[PMID] 33307036.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
Scientific Reports.
11(1)
[DOI] 10.1038/s41598-021-85659-8.
[PMID] 33753784.
2021
Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.644826.
[PMID] 33981285.
2021
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.778912.
[PMID] 34912300.
2021
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series.
Molecular metabolism.
53
[DOI] 10.1016/j.molmet.2021.101323.
[PMID] 34416394.
2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.02180.
[PMID] 33013915.
2020
Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion
Bioelectronics in Medicine.
3(2):17-31
[DOI] 10.2217/bem-2020-0006.
[PMID] 33169091.
2020
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
26(12):1505-1513
[DOI] 10.4158/EP-2020-0295.
[PMID] 33471743.
2020
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell metabolism.
32(6):1041-1051.e6
[DOI] 10.1016/j.cmet.2020.11.005.
[PMID] 33207244.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association.
37(12):2160-2168
[DOI] 10.1111/dme.14361.
[PMID] 32634859.
2020
Large-scale electron microscopy database for human type 1 diabetes.
Nature communications.
11(1)
[DOI] 10.1038/s41467-020-16287-5.
[PMID] 32424134.
2020
Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.
Cell death & disease.
11(2)
[DOI] 10.1038/s41419-020-2269-7.
[PMID] 32080178.
2020
Organisation of the human pancreas in health and in diabetes
Diabetologia.
63(10):1966-1973
[DOI] 10.1007/s00125-020-05203-7.
[PMID] 32894306.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
Diabetes.
69(1):60-66
[DOI] 10.2337/db19-0554.
[PMID] 31597639.
2019
Islet amyloidosis in a child with type 1 diabetes
Islets.
11(2):44-49
[DOI] 10.1080/19382014.2019.1599707.
[PMID] 31084520.
2019
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes
Journal of Histochemistry & Cytochemistry.
67(1):41-52
[DOI] 10.1369/0022155418778546.
[PMID] 29771178.
2019
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
Diabetes Care.
42(2):281-287
[DOI] 10.2337/dc18-1512.
[PMID] 30552130.
2018
High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network.
Journal of visualized experiments : JoVE.
(131)
[DOI] 10.3791/56859.
[PMID] 29443037.
2018
Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-03367-w.
[PMID] 29491378.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism.
103(1):35-45
[DOI] 10.1210/jc.2017-01159.
[PMID] 28938416.
2018
The Role of Accessory Cells in Islet Homeostasis.
Current diabetes reports.
18(11)
[DOI] 10.1007/s11892-018-1096-z.
[PMID] 30267158.
2018
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Cell reports.
22(10):2667-2676
[DOI] 10.1016/j.celrep.2018.02.032.
[PMID] 29514095.
2017
5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy.
25(6):1387-1394
[DOI] 10.1016/j.ymthe.2017.03.029.
[PMID] 28408179.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine.
23(2)
[DOI] 10.1038/nm0217-264a.
[PMID] 28170374.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine.
23(8)
[DOI] 10.1038/nm0817-1004a.
[PMID] 28777787.
2017
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas.
46(2):252-259
[DOI] 10.1097/MPA.0000000000000717.
[PMID] 27984510.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
Diabetes care.
40(9):e122-e123
[DOI] 10.2337/dc17-0996.
[PMID] 28679687.
2017
Immunohistochemistry Staining for Human Alpha-1 Antitrypsin.
Methods in molecular biology (Clifton, N.J.).
1639:139-143
[DOI] 10.1007/978-1-4939-7163-3_13.
[PMID] 28752453.
2017
Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus.
Diabetes care.
40(5):723-725
[DOI] 10.2337/dc16-2127.
[PMID] 28428323.
2017
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
Diabetes.
66(3):722-734
[DOI] 10.2337/db16-1025.
[PMID] 27920090.
2017
Periodic Acid-Schiff Staining with Diastase.
Methods in molecular biology (Clifton, N.J.).
1639:145-149
[DOI] 10.1007/978-1-4939-7163-3_14.
[PMID] 28752454.
2017
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Cell metabolism.
26(3):568-575.e3
[DOI] 10.1016/j.cmet.2017.08.013.
[PMID] 28877460.
2017
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Diabetologia.
60(4):753-755
[DOI] 10.1007/s00125-016-4195-x.
[PMID] 28070616.
2017
Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725.
Diabetes care.
40(10)
[DOI] 10.2337/dci17-0030.
[PMID] 28931713.
2017
Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care.
40(4):577-582
[DOI] 10.2337/dc16-1774.
[PMID] 28115475.
2016
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.
Human pathology.
56:93-100
[DOI] 10.1016/j.humpath.2016.06.006.
[PMID] 27342911.
2016
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine.
22(12):1482-1487
[DOI] 10.1038/nm.4203.
[PMID] 27798614.
2016
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
30(2):983-93
[DOI] 10.1096/fj.15-279810.
[PMID] 26546129.
2016
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.
Diabetes care.
39(9):1650-2
[DOI] 10.2337/dc16-0711.
[PMID] 27555624.
2016
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes.
65(3):719-31
[DOI] 10.2337/db15-0779.
[PMID] 26581594.
2016
Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].
Diabetologia.
59(4):870-2
[DOI] 10.1007/s00125-016-3889-4.
[PMID] 26861059.
2016
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care.
39(7):1292-4
[DOI] 10.2337/dc16-0737.
[PMID] 27330131.
2016
Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
77:21-8
[DOI] 10.1016/j.jcv.2016.01.015.
[PMID] 26875099.
2016
The influence of type 1 diabetes on pancreatic weight.
Diabetologia.
59(1):217-221
[DOI] 10.1007/s00125-015-3752-z.
[PMID] 26358584.
2016
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
JCI insight.
1(20)
[DOI] 10.1172/jci.insight.88242.
[PMID] 27942583.
2015
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
Scientific reports.
5
[DOI] 10.1038/srep13155.
[PMID] 26279095.
2015
Abnormalities of the Exocrine Pancreas in Type 1 Diabetes.
Current diabetes reports.
15(10)
[DOI] 10.1007/s11892-015-0653-y.
[PMID] 26318606.
2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes.
64(11):3873-84
[DOI] 10.2337/db15-0164.
[PMID] 26185279.
2015
Organ donor specimens: What can they tell us about type 1 diabetes?
Pediatric diabetes.
16(5):320-30
[DOI] 10.1111/pedi.12286.
[PMID] 25998576.
2015
Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes.
PloS one.
10(8)
[DOI] 10.1371/journal.pone.0135663.
[PMID] 26302420.
2014
New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
Current diabetes reports.
14(10)
[DOI] 10.1007/s11892-014-0530-0.
[PMID] 25142715.
2014
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes.
15(1):1-9
[DOI] 10.1111/pedi.12097.
[PMID] 24325575.
2013
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.
The Journal of clinical investigation.
123(12):5310-8
[DOI] 10.1172/JCI70314.
[PMID] 24231351.
2013
Increased complement activation in human type 1 diabetes pancreata.
Diabetes care.
36(11):3815-7
[DOI] 10.2337/dc13-0203.
[PMID] 24041678.
2013
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.
Diabetes.
62(7):2595-604
[DOI] 10.2337/db12-1686.
[PMID] 23524641.
2013
Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.
Diabetes.
62(10):e19-22
[DOI] 10.2337/db13-0996.
[PMID] 24065800.
2013
The diagnosis of insulitis in human type 1 diabetes.
Diabetologia.
56(11):2541-3
[DOI] 10.1007/s00125-013-3043-5.
[PMID] 24006089.
2012
Alpha-1 Antitrypsin (Aat) Expression 1 Year After Im Administration of Raav1-Cb-Haat in a Phase 2 Clinical Trial
Molecular Therapy.
20:S91-S92
2012
Collection protocol for human pancreas.
Journal of visualized experiments : JoVE.
(63)
[DOI] 10.3791/4039.
[PMID] 22665046.
2012
Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.
Neurobiology of learning and memory.
97(1):69-80
[DOI] 10.1016/j.nlm.2011.09.006.
[PMID] 21982980.
2012
Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology.
302(3):G296-308
[DOI] 10.1152/ajpgi.00562.2010.
[PMID] 22114116.
2012
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews.
28(7):608-17
[DOI] 10.1002/dmrr.2316.
[PMID] 22585677.
2012
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA.
308(22):2337-9
[DOI] 10.1001/jama.2012.15008.
[PMID] 23232891.
2012
Staining protocols for human pancreatic islets.
Journal of visualized experiments : JoVE.
(63)
[DOI] 10.3791/4068.
[PMID] 22665223.
2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine.
9
[DOI] 10.1186/1479-5876-9-21.
[PMID] 21345239.
2011
Clinical Manifestations of Heterozygous Expression of a Mutation That Causes Glycogen Storage Disease Type Ia in Dogs
Journal of Veterinary Internal Medicine.
25:731-732
2011
Glycogen storage disease type Ia in canines: a model for human metabolic and genetic liver disease.
Journal of biomedicine & biotechnology.
2011
[DOI] 10.1155/2011/646257.
[PMID] 21318173.
2011
N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance.
American journal of respiratory cell and molecular biology.
44(6):824-30
[DOI] 10.1165/rcmb.2009-0285OC.
[PMID] 20693405.
2011
Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.
Human gene therapy.
22(10):1239-47
[DOI] 10.1089/hum.2011.053.
[PMID] 21609134.
2011
Salivary PYY: a putative bypass to satiety.
PloS one.
6(10)
[DOI] 10.1371/journal.pone.0026137.
[PMID] 22028819.
2011
Selective stimulation of VEGFR2 accelerates progressive renal disease.
The American journal of pathology.
179(1):155-66
[DOI] 10.1016/j.ajpath.2011.03.024.
[PMID] 21640973.
2011
The pancreas in human type 1 diabetes.
Seminars in immunopathology.
33(1):29-43
[DOI] 10.1007/s00281-010-0208-x.
[PMID] 20495921.
2010
Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia.
Human gene therapy.
21(7):903-10
[DOI] 10.1089/hum.2009.157.
[PMID] 20163245.
2010
Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells.
Cancer biology & therapy.
10(8):758-64
[PMID] 20699653.
2010
Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis.
The journal of gene medicine.
12(1):35-44
[DOI] 10.1002/jgm.1409.
[PMID] 19866480.
2010
Diabetic eNOS-knockout mice develop accelerated retinopathy.
Investigative ophthalmology & visual science.
51(10):5240-6
[DOI] 10.1167/iovs.09-5147.
[PMID] 20435587.
2010
Dimorphic histopathology of long-standing childhood-onset diabetes.
Diabetologia.
53(4):690-8
[DOI] 10.1007/s00125-009-1642-y.
[PMID] 20062967.
2010
Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.
The American journal of pathology.
176(5):2198-208
[DOI] 10.2353/ajpath.2010.090316.
[PMID] 20363914.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(8):1553-8
[DOI] 10.1038/mt.2010.116.
[PMID] 20551917.
2010
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications.
24(3):163-7
[DOI] 10.1016/j.jdiacomp.2008.12.004.
[PMID] 19217320.
2010
Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(3):502-10
[DOI] 10.1038/mt.2009.305.
[PMID] 20104213.
2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia.
53(10):2198-204
[DOI] 10.1007/s00125-010-1829-2.
[PMID] 20593162.
2010
Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
American journal of physiology. Renal physiology.
298(3):F609-16
[DOI] 10.1152/ajprenal.00377.2009.
[PMID] 20015944.
2009
Amelioration of Insulitis and Reversal of Diabetes in Nod Mice By Murine Anti-Thymocyte Globulin and Granulocyte-Colony Stimulating Factor Combination Therapy
Clinical Immunology.
131:S48-S49
[DOI] 10.1016/j.clim.2009.03.137.
2009
Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse.
American journal of physiology. Renal physiology.
296(2):F317-27
[DOI] 10.1152/ajprenal.90450.2008.
[PMID] 19036847.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes.
58(10):2277-84
[DOI] 10.2337/db09-0557.
[PMID] 19628781.
2009
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology.
174(4):1221-9
[DOI] 10.2353/ajpath.2009.080605.
[PMID] 19246639.
2009
Modulation of Long-Term Feeding Behavior and Social Interactions Using Non-Invasive Gene Therapy With Recombinant Aav Vectors
Molecular Therapy.
17
2009
Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research.
72:156-157
2009
Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia.
52(2):262-70
[DOI] 10.1007/s00125-008-1200-z.
[PMID] 19002428.
2009
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950).
182(8):4608-15
[DOI] 10.4049/jimmunol.0713269.
[PMID] 19342635.
2009
Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery.
Molecular therapy : the journal of the American Society of Gene Therapy.
17(1):81-7
[DOI] 10.1038/mt.2008.217.
[PMID] 18941444.
2009
Systemic Expression of Transgene Product Is Not Required for Induction of Immune Tolerance By Aav2 Hepatic Gene Transfer
Molecular Therapy.
17
2009
The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model.
Gene therapy.
16(2):172-83
[DOI] 10.1038/gt.2008.156.
[PMID] 18818669.
2008
Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD.
Human gene therapy.
19(6):579-88
[DOI] 10.1089/hum.2007.168.
[PMID] 18500942.
2008
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences.
1150:152-6
[DOI] 10.1196/annals.1447.049.
[PMID] 19120286.
2008
Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5.
Digestive diseases and sciences.
53(5):1261-70
[PMID] 17934813.
2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes.
57(2):405-14
[PMID] 18039815.
2008
p53 regulates FAK expression in human tumor cells.
Molecular carcinogenesis.
47(5):373-82
[PMID] 17999388.
2008
Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene.
The journal of gene medicine.
10(1):51-60
[PMID] 18023072.
2008
Recombinant adeno-associated virus-mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD-deficient mice.
The journal of gene medicine.
10(10):1113-23
[DOI] 10.1002/jgm.1242.
[PMID] 18720429.
2008
The Pivotal Role of Vegf On Glomerular Macrophage Infiltration in Advanced Diabetic Nephropathy
Modern Pathology.
88(3):949-961
[DOI] 10.1038/labinvest.
[PMID] 24336072.
2008
The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology.
88(9):949-61
[DOI] 10.1038/labinvest.2008.60.
[PMID] 18607348.
2007
Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
7(5):1112-20
[PMID] 17456199.
2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes.
56(5):1316-23
[PMID] 17360983.
2007
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
Journal of the American Society of Nephrology : JASN.
18(2):539-50
[PMID] 17202420.
2007
Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol.
Journal of molecular endocrinology.
39(4):223-37
[PMID] 17909263.
2007
Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats.
American journal of physiology. Endocrinology and metabolism.
293(3):E726-36
[PMID] 17578883.
2007
In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells.
Molecular carcinogenesis.
46(7):512-23
[PMID] 17393410.
2007
In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.
Laboratory investigation; a journal of technical methods and pathology.
87(9):893-902
[PMID] 17592477.
2007
Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites.
Human gene therapy.
18(3):245-56
[PMID] 17376008.
2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy.
17(6):625-34
[PMID] 16776571.
2006
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes.
55(7):1939-45
[PMID] 16804061.
2006
Long-term monitoring of transplanted islets using positron emission tomography.
Molecular therapy : the journal of the American Society of Gene Therapy.
14(6):851-6
[PMID] 16982215.
2006
Noninvasive imaging of islet grafts using positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America.
103(30):11294-9
[PMID] 16868090.
2006
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
The journal of gene medicine.
8(6):730-5
[PMID] 16518879.
2005
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology.
79(2):1045-52
[PMID] 15613333.
2005
Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector.
Molecular therapy : the journal of the American Society of Gene Therapy.
12(5):867-75
[PMID] 16085464.
2005
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy.
16(2):235-47
[PMID] 15761263.
2005
Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract.
American journal of physiology. Gastrointestinal and liver physiology.
288(5):G1036-47
[PMID] 15576624.
2005
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America.
102(20):7251-6
[PMID] 15878989.
2005
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy.
12(3):519-27
[PMID] 15979413.
2005
Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system.
Molecular therapy : the journal of the American Society of Gene Therapy.
12(6):1217-25
[PMID] 16213797.
2005
Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.
Transplantation.
80(4):530-3
[PMID] 16123729.
2004
Bioluminescent monitoring of islet graft survival after transplantation.
Molecular therapy : the journal of the American Society of Gene Therapy.
9(3):428-35
[PMID] 15006610.
2004
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology.
165(3):1045-53
[PMID] 15331427.
2004
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Gene therapy.
11(3):233-40
[PMID] 14737082.
2004
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
Gene therapy.
11(2):181-6
[PMID] 14712302.
2003
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes.
52(3):708-16
[PMID] 12606512.
2003
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.
Proceedings of the National Academy of Sciences of the United States of America.
100(24):14217-22
[PMID] 14617771.
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950).
171(5):2270-8
[PMID] 12928371.
2002
Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects.
Molecular therapy : the journal of the American Society of Gene Therapy.
6(3):329-35
[PMID] 12231168.
2001
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America.
98(24):13913-8
[PMID] 11717448.
1999
17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N’-nitro-nitrosoguanidine.
Endocrinology.
140(10):4886-94
[PMID] 10499548.
1998
Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta.
The American journal of physiology.
274(3):C603-14
[DOI] 10.1152/ajpcell.1998.274.3.C603.
[PMID] 9530091.
1997
Estrogen receptor alpha and beta expression in upper gastrointestinal tract with regulation of trefoil factor family 2 mRNA levels in ovariectomized rats.
Biochemical and biophysical research communications.
240(2):478-83
[PMID] 9388504.
1995
In situ hybridization of H-K-ATPase beta-subunit mRNA in rat and rabbit kidney.
The American journal of physiology.
269(3 Pt 2):F345-54
[PMID] 7573483.
1995
Induction and immunolocalization of manganese superoxide dismutase in acute acetic acid-induced colitis in the rat.
Gastroenterology.
109(3):800-11
[PMID] 7657108.
1995
Regulation of manganese superoxide dismutase during acute colitis: specific induction in rat colonic glandular epithelium, smooth muscle, and myenteric neurons
Gastroenterology.
109:800-812
1994
Secretagogue-induced [14C]aminopyrine uptake in isolated equine parietal cells.
American journal of veterinary research.
55(1):132-7
[PMID] 7511358.
1993
Canine parietal cell binding by antibodies to the complementary peptide of somatostatin.
The American journal of the medical sciences.
305(6):365-73
[PMID] 8099469.
1992
Complementary peptide to the carboxyl-terminal tetrapeptide of gastrin.
Gastroenterology.
103(3):749-58
[PMID] 1499924.
1990
Basal and pentagastrin-stimulated gastric secretion in young horses.
The American journal of physiology.
259(6 Pt 2):R1259-66
[PMID] 2260736.
1989
Effect of butorphanol on equine antroduodenal motility.
Equine veterinary journal. Supplement.
(7):21-3
[PMID] 9118100.
1989
Effect of xylazine treatment on equine proximal gastrointestinal tract myoelectrical activity.
American journal of veterinary research.
50(6):945-9
[PMID] 2764348.
1989
Upper gastrointestinal surgery for ulcer disease in foals.
The Veterinary clinics of North America. Equine practice.
5(2):351-62
[PMID] 2670112.
1987
Effect of ranitidine on gastric acid secretion in young male horses.
American journal of veterinary research.
48(10):1511-5
[PMID] 3674562.
1986
Gastroenterostomy for treatment of gastroduodenal ulcer disease in 14 foals.
Journal of the American Veterinary Medical Association.
188(8):840-4
[PMID] 3710873.
Donor Eligibility Criteria and Pancreas Recovery for HuBMAP TMC-PNNL-UF v1
.
[DOI] 10.17504/protocols.io.b7gurjww.
Donor Eligibility Criteria and Pancreas Recovery for HuBMAP TMC-PNNL-UF v2
.
[DOI] 10.17504/protocols.io.b7nfrmbn.
Human Islet Microvasculature Image Processing v1
.
[DOI] 10.17504/protocols.io.wxbffin.
Human Islet Microvasculature Immunofluorescence in Optically Cleared Samples v1
.
[DOI] 10.17504/protocols.io.y3tfynn.
Human Pancreas Histopathology Assessment v1
.
[DOI] 10.17504/protocols.io.br7tm9nn.
Human Pancreas Optical Clearing by iDISCO and VISIKOL v1
.
[DOI] 10.17504/protocols.io.ba4qigvw.
Grants
Sep 2022
ACTIVE
Survival and potential of insulin-deficient beta cells in type 1 diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2022
ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jun 2022
ACTIVE
Deep Learning-based Analyses of Pancreatic Islet Beta-Cell Heterogeneity and MRI Pancreas Volume as Biomarkers to Improve Understanding of Type 1 Diabetes Progression
Role: Co-Investigator
Funding: JDRF
May 2022
ACTIVE
Energy balance, mTOR pathway signaling, and breast cancer prognosis
Role: Principal Investigator
Funding: OHIO STATE UNIV
via NATL INST OF HLTH NCI
Oct 2021
ACTIVE
Characterization of pancreatic Tregs in T1D patients and at risk subjects in comparison to normal control donors
Role: Principal Investigator
Funding: TREX BIO
Sep 2021
ACTIVE
Natural History and Mechanisms of Exocrine Pancreatic Dysfunction in Pre-Type 1 Diabetes
Role: Other
Funding: NATL INST OF HLTH NIDDK
Oct 2020
ACTIVE
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
Role: Co-Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Sep 2020
ACTIVE
Type 1 Diabetes in Acute Pancreatitis Consortium – Clinical Centers
Role: Other
Funding: NATL INST OF HLTH NIDDK
Aug 2020
ACTIVE
Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2020
ACTIVE
Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes
Role: Principal Investigator
Funding: BATTELLE MEMORIAL INST
via NATL INST OF HLTH NIDDK
Jul 2019
ACTIVE
Zip Proteins and Iron Metabolism
Role: Other
Funding: NATL INST OF HLTH NIDDK
Nov 2018
– Aug 2020
Neural regulation of alpha cell function and dysregulation in type 1 diabetes
Role: Principal Investigator
Funding: JDRF
Sep 2018
ACTIVE
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jun 2018
– May 2023
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2018
ACTIVE
Network for Pancreatic Organ Donors – nPOD
Role: Co-Investigator
Funding: JDRF
Jan 2018
– Mar 2022
Collaborative Type 1 Diabetes Research Project: The Network for Pancreatic Organ donors with Diabetes (nPOD)
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2017
– Mar 2021
Cognitive Augmentation through Neuroplasticity (CAN)
Role: Project Manager
Funding: US DEPT OF DEFENSE DARPA
Sep 2016
– Jul 2020
Neuromodulation-based treatment of diabetes: identifying anatomical and physiological pancreatic innervation targets
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Sep 2016
– Dec 2017
The George S. Eisenbarth nPOD Award for Team Science
Role: Principal Investigator
Funding: UNIV OF MIAMI
via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Nov 2015
– Sep 2016
Beta Cell Regeneration For Type 1 Diabetes
Role: Principal Investigator
Funding: UNIV OF MIAMI
via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Sep 2014
– Aug 2018
Defining Islet Heterogeneity Using Single Islet Transcriptomics
Role: Principal Investigator
Funding: UNIV OF TENNESSEE
via NATL INST OF HLTH NIDDK
Sep 2013
– Aug 2017
Pancreatic Volume in Preclinical Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2013
– Mar 2018
NPOD Coordinating Center
Role: Project Manager
Funding: JDRF
Sep 2012
– Aug 2016
The JDRF nPOD Viral Work Group: nPOD V
Role: Project Manager
Funding: JDRF
Education
Postdoctoral associate
1988-1990
·
University of Florida, College of Medicine, Department of Medicine, Gastroenterology and Hepatology Division
Ph.D. Physiological Sciences, College of Veterinary Medicine
1988
·
University of Florida
D.V.M., Honors, College of Veterinary Medicine
1980
·
University of Florida
B.S., High Honors, Chemistry
1976
·
University of Florida
Contact Details
Phones:
- Business:
- (352) 273-6129
Emails:
- Business:
- mct@ufl.edu
Administrative Support Ast I:
Addresses:
- Business Mailing:
-
PATHOLOGY, IMMUNOLOGY AND LABORATORY MEDICIN
1395 Center Drive, D11-38A
POB 100275
GAINESVILLE FL 32610 - Business Street:
-
Room D11-38A
PO Box 100275
1395 Center Drive, Pathology, Immunology, and Lab. Med.
Gainesville FL 32610