William L Clapp, M.D.
CLIN PROF
About William L Clapp
Dr. William L. Clapp serves as Professor and Director of Renal Pathology in the Department of Pathology, Immunology and Laboratory Medicine. The Renal Pathology service is one of the busiest in the southeastern U.S. and evaluates native and transplant renal biopsies, from UF Health and from numerous other institutions in Florida, including in Orlando, Tampa and Miami.
Dr. Clapp’s teaching interests and responsibilities include the Directorship of the Kidney and Urinary Tract (KUT) course for University of Florida College of Medicine students. He has taught renal pathology in the UF COM for numerous years. For several years, he also taught the cell and molecular biology of cancer.
Accomplishments
Basic Science Teacher of the Year
2015
·
University of Florida College of Medicine
Exemplary Teacher Award
2004
·
University of Florida College of Medicine
Basic Science Teacher of the Year
2002
·
University of Florida College of Medicine
Teaching Excellence Awards
1995-2020
·
UF COM student classes
Individual National Research Service Award, NIH
1984-1987
·
National Institutes of Health
Alpha Omega Alpha Honor Medical Society
1976
·
University of Tennessee College of Medicine
Teaching Profile
Courses Taught
2015,2018-2020,2020-2024
BMS6638C Kidney & Urinary Tract
2011-2016
DEN6350 General Pathology
Board Certifications
-
HematologyAmerican Board of Pathology
-
Pathology – Anatomic and ClinicalAmerican Board of Pathology
Clinical Profile
Specialties
- Hematology
Subspecialties
- Anatomic and Clinical Pathology
Research Profile
Research interests include diagnostic aspects and also underlying mechanisms of kidney diseases, especially autoimmune diseases, and also renal development and renal structural-functional correlates.
Publications
Academic Articles
2024
Association of Oral Tobacco-Free Nicotine Delivery Product with Acute Renal Tubular Necrosis.
Medicina (Kaunas, Lithuania).
60(11)
[DOI] 10.3390/medicina60111846.
[PMID] 39597031.
2024
ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.03.21.586102.
[PMID] 38585837.
2024
ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology.
Proceedings of SPIE–the International Society for Optical Engineering.
12933
[DOI] 10.1117/12.3008469.
[PMID] 38813089.
2024
Efficacy and Safety of Eculizumab in Enteroaggregative E. coli Associated Hemolytic Uremic Syndrome.
Pediatric reports.
16(1):26-34
[DOI] 10.3390/pediatric16010003.
[PMID] 38251312.
2024
Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.10.15.618563.
[PMID] 39464003.
2024
Investigating quantitative histological characteristics in renal pathology using HistoLens.
Scientific reports.
14(1)
[DOI] 10.1038/s41598-024-68406-7.
[PMID] 39080444.
2024
Safety and Efficacy of Very Early Conversion to Belatacept in Pediatric Kidney Transplantation with Transplant-Associated Thrombotic Microangiopathy: Case Study and Review of Literature.
Clinics and practice.
14(3):882-891
[DOI] 10.3390/clinpract14030069.
[PMID] 38804401.
2023
A Novel Form of Renal Tubular Acidosis Associated With Immune Checkpoint Inhibitors.
Kidney international reports.
8(1):197-201
[DOI] 10.1016/j.ekir.2022.10.019.
[PMID] 36644354.
2023
Correlating Deep Learning-Based Automated Reference Kidney Histomorphometry with Patient Demographics and Creatinine.
Kidney360.
4(12):1726-1737
[DOI] 10.34067/KID.0000000000000299.
[PMID] 37966063.
2023
Does kidney biopsy in pediatric lupus patients “complement” the management and outcomes of silent lupus nephritis? Lessons learned from a pediatric cohort.
Pediatric nephrology (Berlin, Germany).
38(8):2669-2678
[DOI] 10.1007/s00467-022-05859-w.
[PMID] 36688943.
2023
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis.
Clinical immunology (Orlando, Fla.).
248
[DOI] 10.1016/j.clim.2022.109213.
[PMID] 36566913.
2023
Pharmacologic inhibition of glycolysis prevents the development of lupus by altering the gut microbiome in mice.
iScience.
26(7)
[DOI] 10.1016/j.isci.2023.107122.
[PMID] 37416482.
2022
Definition, diagnosis and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet Working Group on Kidney Malformations.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
37(12):2351-2362
[DOI] 10.1093/ndt/gfac207.
[PMID] 35772019.
2022
Minimal change disease after multiple wasp stings.
Clinical nephrology. Case studies.
10:16-20
[DOI] 10.5414/CNCS110369.
[PMID] 35096510.
2022
Virus-Derived Chemokine Modulating Protein Pre-Treatment Blocks Chemokine-Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage.
Pathogens (Basel, Switzerland).
11(5)
[DOI] 10.3390/pathogens11050588.
[PMID] 35631109.
2021
Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.).
73(8):1467-1477
[DOI] 10.1002/art.41677.
[PMID] 33559374.
2021
Collapsing glomerulopathy in a patient with mixed connective tissue disease.
CEN case reports.
10(2):189-193
[DOI] 10.1007/s13730-020-00542-1.
[PMID] 33052525.
2021
Incidental Finding of a Large Right Atrial Thrombus in a Patient With Cerebral Lymphoma.
Journal of investigative medicine high impact case reports.
9
[DOI] 10.1177/23247096211001636.
[PMID] 33749363.
2021
LC-MS lipidomics of renal biopsies for the diagnosis of Fabry disease.
Journal of mass spectrometry and advances in the clinical lab.
22:71-78
[DOI] 10.1016/j.jmsacl.2021.11.004.
[PMID] 34918004.
2021
Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
27(8S):S618-S619
[DOI] 10.1097/RHU.0000000000001730.
[PMID] 33843777.
2021
Mixed acinar-neuroendocrine carcinoma with amphicrine features of the pancreas: Two rare cases with diffuse co-expression of acinar and neuroendocrine markers.
Pathology international.
71(7):485-487
[DOI] 10.1111/pin.13105.
[PMID] 34000758.
2020
Infection-related Glomerulonephritis and C3 Glomerulonephritis – Similar Yet Dissimilar: A Case Report and Brief Review of Current Literature.
Cureus.
12(2)
[DOI] 10.7759/cureus.7127.
[PMID] 32140372.
2020
Inhibition of IRF5 hyperactivation protects from lupus onset and severity.
The Journal of clinical investigation.
130(12):6700-6717
[DOI] 10.1172/JCI120288.
[PMID] 32897883.
2020
Liver Pathology in Mitochondrial Complex I Deficiency from Bi-Allelic Mutations in NDUFS2: A Report of Findings at Autopsy.
Fetal and pediatric pathology.
39(3):259-262
[DOI] 10.1080/15513815.2019.1651800.
[PMID] 31411514.
2019
Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?
Trends in molecular medicine.
25(7):626-639
[DOI] 10.1016/j.molmed.2019.04.002.
[PMID] 31109797.
2019
Pauci-immune proliferative glomerulonephritis and fungal endocarditis: More than a mere coincidence?
BMJ case reports.
12(3)
[DOI] 10.1136/bcr-2018-229059.
[PMID] 30846459.
2019
Podocyte-specific expression of Cre recombinase promotes glomerular basement membrane thickening.
American journal of physiology. Renal physiology.
316(5):F1026-F1040
[DOI] 10.1152/ajprenal.00359.2018.
[PMID] 30810063.
2019
Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice.
Journal of inflammation (London, England).
16
[DOI] 10.1186/s12950-019-0215-1.
[PMID] 31160886.
2018
IgA nephropathy in African Americans: uncommon but possible.
JRSM open.
9(6)
[DOI] 10.1177/2054270418783902.
[PMID] 29942535.
2018
Not all kidney disease in patients with diabetes is diabetic nephropathy.
Internal and emergency medicine.
13(7):1131-1132
[DOI] 10.1007/s11739-018-1895-x.
[PMID] 29922901.
2018
Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-31779-7.
[PMID] 30194334.
2018
The skin-kidney connection: bullous pemphigoid associated with acute allograft rejection and membranous nephropathy.
Clinical case reports.
6(2):432-433
[DOI] 10.1002/ccr3.1324.
[PMID] 29445491.
2017
Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney.
American journal of physiology. Renal physiology.
312(3):F427-F435
[DOI] 10.1152/ajprenal.00559.2016.
[PMID] 27927654.
2017
Trifecta of light chain cast nephropathy, monoclonal plasma cell infiltrates, and light chain proximal tubulopathy.
Kidney international.
92(6)
[DOI] 10.1016/j.kint.2017.08.010.
[PMID] 29153147.
2017
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
37(1):78-86
[DOI] 10.1016/j.nefro.2016.05.011.
[PMID] 27595516.
2016
Pathogenesis of proteinuria in idiopathic minimal change disease: molecular mechanisms.
Pediatric nephrology (Berlin, Germany).
31(12):2179-2189
[PMID] 27384691.
2015
Osteogenic changes in kidneys of hyperoxaluric rats.
Biochimica et biophysica acta.
1852(9):2000-12
[DOI] 10.1016/j.bbadis.2015.06.020.
[PMID] 26122267.
2015
Repurposed biological scaffolds: kidney to pancreas.
Organogenesis.
11(2):47-57
[DOI] 10.1080/15476278.2015.1067354.
[PMID] 26252820.
2014
Bioengineered Pancreas: Human Insulin-Secreting Islet Cells in Vascularized Pig Kidney Scaffolds
Nephrology Dialysis Transplantation.
29(3)
2014
Isolation of Tacaribe virus, a Caribbean arenavirus, from host-seeking Amblyomma americanum ticks in Florida.
PloS one.
9(12)
[DOI] 10.1371/journal.pone.0115769.
[PMID] 25536075.
2013
Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney.
American journal of physiology. Renal physiology.
304(7):F972-81
[DOI] 10.1152/ajprenal.00550.2012.
[PMID] 23324176.
2013
Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer.
International journal of nanomedicine.
8:4481-94
[DOI] 10.2147/IJN.S41782.
[PMID] 24293999.
2012
Mouse stem cells seeded into decellularized rat kidney scaffolds endothelialize and remodel basement membranes.
Organogenesis.
8(2):49-55
[DOI] 10.4161/org.20209.
[PMID] 22692231.
2011
A new form of myeloma “kidney”: shortened hemofilter survival and implications for membrane filtration plasmapheresis.
Clinical nephrology.
75(2):120-4
[PMID] 21255541.
2011
Primary renal carcinoid tumors: clinicopathologic features of 9 cases with emphasis on novel immunohistochemical findings.
Human pathology.
42(10):1554-61
[DOI] 10.1016/j.humpath.2010.12.019.
[PMID] 21496872.
2009
B-cell lymphoma with Mott cell differentiation in two young adult dogs.
Veterinary clinical pathology.
38(1):113-20
[DOI] 10.1111/j.1939-165X.2008.00101.x.
[PMID] 19171017.
2009
Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds.
Journal of the American Society of Nephrology : JASN.
20(11):2338-47
[DOI] 10.1681/ASN.2008111196.
[PMID] 19729441.
2009
Hematology of healthy Florida manatees (Trichechus manatus).
Veterinary clinical pathology.
38(2):183-93
[DOI] 10.1111/j.1939-165X.2009.00113.x.
[PMID] 19490571.
2008
Sebastian syndrome with abnormal platelet response to ristocetin.
Laboratory hematology : official publication of the International Society for Laboratory Hematology.
14(3):19-23
[DOI] 10.1532/LH96.08007.
[PMID] 18812282.
2008
Shortened hemofilter survival time due to lipid infusion in continuous renal replacement therapy.
Nephron. Clinical practice.
108(1):c5-9
[PMID] 18059111.
2007
A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.
Antimicrobial agents and chemotherapy.
51(5):1855-8
[PMID] 17325226.
2006
Acute-onset hearing loss with renal failure: differential diagnosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
47(3):553-8
[PMID] 16490636.
2006
Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney.
Journal of the American Society of Nephrology : JASN.
17(10):2670-9
[PMID] 16928804.
2003
Tissue adhesion to bioactive glass-coated silicone tubing in a rat model of peritoneal dialysis catheters and catheter tunnels.
Kidney international.
63(2):702-8
[PMID] 12631137.
2002
Malignant mesothelioma of tunica vaginalis testis: a fatal case with liver metastasis.
The Journal of urology.
167(2 Pt 1):645-6
[PMID] 11792939.
2001
Outcome of kidney transplants in patients known to be flow cytometry crossmatch positive.
Transplantation.
71(8):1098-102
[PMID] 11374409.
2000
Proteinuria: potential causes and approach to evaluation.
The American journal of the medical sciences.
320(3):188-94
[PMID] 11014373.
1996
Macrophages and chronic renal allograft nephropathy.
Kidney international. Supplement.
57:S42-9
[PMID] 8941921.
1995
Thromboxane synthase expression in renal transplant patients with rejection.
Transplantation.
59(4):490-4
[PMID] 7878751.
1994
Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney.
Kidney international.
46(3):653-65
[PMID] 7527874.
1994
Segmental localization of mRNAs encoding Na(+)-K(+)-ATPase alpha- and beta-subunit isoforms in rat kidney using RT-PCR.
Kidney international.
46(3):627-38
[PMID] 7996786.
1993
Regulation of kidney organogenesis: homeobox genes, growth factors, and Wilms tumor.
Current opinion in nephrology and hypertension.
2(3):419-29
[PMID] 7922202.
1989
Morphologic heterogeneity along the rat inner medullary collecting duct.
Laboratory investigation; a journal of technical methods and pathology.
60(2):219-30
[PMID] 2915516.
1988
Axial heterogeneity in the handling of albumin by the rabbit proximal tubule.
Laboratory investigation; a journal of technical methods and pathology.
58(5):549-58
[PMID] 3367637.
1988
Structure and function of the inner medullary collecting duct.
Kidney international.
34(4):441-54
[PMID] 3059025.
1987
Ultrastructural localization of acidic compartments in cells of isolated rabbit PCT.
The American journal of physiology.
253(1 Pt 2):F95-103
[PMID] 2440316.
Grants
Sep 2024
ACTIVE
Computational Imaging of Renal Structures for Diagnosing Diabetic Nephropathy.
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2023
ACTIVE
Computational Image Analysis of Renal Transplant Biopsies to Predict Graft Outcome
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Education
Fellowship – Hematology
1981
·
National Naval Medical Center
Residency – Pathology – Anatomic and Clinical
1980
·
National Naval Medical Center
Internship – Pathology – Anatomic and Clinical
1977
·
National Naval Medical Center
Medical Degree
1976
·
University of Tenneessee
Contact Details
Phones:
- Business:
- (352) 265-9900
Emails:
- Business:
- bevemara@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100275
GAINESVILLE FL 32610 - Business Street:
-
4800 SW 35TH DR
GAINESVILLE FL 32608