Clayton Mathews,
Sebastian Family Professor
Teaching Profile
Courses Taught
2020-2021
GMS6143 Cells of the Innate Immune System
2008-2023
GMS5905 Special Topics in Biomedical Sciences
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
MCB7979 Advanced Research
2018
BME7980 Research for Doctoral Dissertation
2015-2017
GMS6895 CTS Journal Club
2014
GMS6140 Principles of Immunology
2012
GMS6382 Special Topics in Immunology
2010
IDH4917 Undergrad Research
2010
GMS6921 Immunology/Microbiology Journal Colloquy
2021
VME6505 Autoimmunity
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-8817-6355
Publications
2024
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes.
Diabetes care.
47(2):285-289
[DOI] 10.2337/dc23-1750.
[PMID] 38117469.
2024
NADPH Oxidase 2–Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function
The Journal of Immunology.
212(2):258-270
[DOI] 10.4049/jimmunol.2200691.
[PMID] 38079221.
2024
Proteome-scale tissue mapping using mass spectrometry based on label-free and multiplexed workflows.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.03.04.583367.
[PMID] 38496682.
2024
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
Nature cell biology.
26(3):421-437
[DOI] 10.1038/s41556-024-01368-0.
[PMID] 38409327.
2024
Serum from pregnant donors induces human beta cell proliferation.
Islets.
16(1)
[DOI] 10.1080/19382014.2024.2334044.
[PMID] 38533763.
2023
A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.
Scientific data.
10(1)
[DOI] 10.1038/s41597-023-02244-6.
[PMID] 37237059.
2023
Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America.
120(49)
[DOI] 10.1073/pnas.2312039120.
[PMID] 38015847.
2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes
JCI Insight.
8(17)
[DOI] 10.1172/jci.insight.170767.
[PMID] 37498686.
2023
Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cells.
Frontiers in immunology.
14
[DOI] 10.3389/fimmu.2023.1142648.
[PMID] 37325626.
2023
Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.02.16.528701.
[PMID] 36824909.
2023
Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes
JCI Insight.
8(16)
[DOI] 10.1172/jci.insight.161812.
[PMID] 37432736.
2023
Serum from pregnant donors induces human beta cell proliferation and insulin secretion.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.04.17.537214.
[PMID] 37131658.
2022
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
Nature Communications.
13(1)
[DOI] 10.1038/s41467-022-32425-7.
[PMID] 35941159.
2022
Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study.
Frontiers in endocrinology.
13
[DOI] 10.3389/fendo.2022.881997.
[PMID] 35957810.
2022
Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage.
Frontiers in genetics.
13
[DOI] 10.3389/fgene.2022.994501.
[PMID] 36276935.
2022
Nanovesicles From Lactobacillus johnsonii N6.2 Reduce Apoptosis in Human Beta Cells by Promoting AHR Translocation and IL10 Secretion.
Frontiers in immunology.
13
[DOI] 10.3389/fimmu.2022.899413.
[PMID] 35757772.
2022
Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes.
Frontiers in endocrinology.
13
[DOI] 10.3389/fendo.2022.861985.
[PMID] 35498413.
2022
The Foundation for Engineering a Pancreatic Islet Niche.
Frontiers in endocrinology.
13
[DOI] 10.3389/fendo.2022.881525.
[PMID] 35600597.
2021
ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
Diabetes.
70(11):2554-2567
[DOI] 10.2337/db20-0873.
[PMID] 34380694.
2021
Erratum. NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T-Cell Numbers. Diabetes 2020;69:1749-1762.
Diabetes.
70(9)
[DOI] 10.2337/db21-er09a.
[PMID] 34244240.
2021
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America.
118(41)
[DOI] 10.1073/pnas.2107208118.
[PMID] 34611019.
2021
Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.636618.
[PMID] 33717184.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-85659-8.
[PMID] 33753784.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Diabetes.
70(5):1123-1129
[DOI] 10.2337/db20-1103.
[PMID] 33632742.
2021
Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3.
Endocrinology, diabetes & metabolism.
4(1)
[DOI] 10.1002/edm2.187.
[PMID] 33532620.
2021
Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices.
Journal of visualized experiments : JoVE.
(170)
[DOI] 10.3791/62207.
[PMID] 33900291.
2021
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation
The Journal of Immunology.
207(3):849-859
[DOI] 10.4049/jimmunol.2000708.
[PMID] 34301848.
2021
Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.622647.
[PMID] 33841327.
2021
Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.707881.
[PMID] 34305820.
2021
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.737276.
[PMID] 34858326.
2020
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
34(11):14832-14849
[DOI] 10.1096/fj.202001495R.
[PMID] 32918763.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics.
22(12):948-953
[DOI] 10.1089/dia.2020.0305.
[PMID] 32833543.
2020
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
The Journal of nutritional biochemistry.
81
[DOI] 10.1016/j.jnutbio.2020.108381.
[PMID] 32422424.
2020
Innate inflammation drives NK cell activation to impair Treg activity.
Journal of autoimmunity.
108
[DOI] 10.1016/j.jaut.2020.102417.
[PMID] 32035746.
2020
Lipid mediators and biomarkers associated with type 1 diabetes development
JCI Insight.
5(16)
[DOI] 10.1172/jci.insight.138034.
[PMID] 32814707.
2020
NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T-Cell Numbers
Diabetes.
69(8):1749-1762
[DOI] 10.2337/db19-0979.
[PMID] 32535552.
2019
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.
Analytical chemistry.
91(9):5794-5801
[DOI] 10.1021/acs.analchem.9b00024.
[PMID] 30843680.
2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology.
10
[DOI] 10.3389/fimmu.2019.00952.
[PMID] 31118934.
2019
Position β57 of I-A g7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
Science Immunology.
4(38)
[DOI] 10.1126/sciimmunol.aaw6329.
[PMID] 31471352.
2018
Abnormal islet sphingolipid metabolism in type 1 diabetes.
Diabetologia.
61(7):1650-1661
[DOI] 10.1007/s00125-018-4614-2.
[PMID] 29671030.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-22574-5.
[PMID] 29540798.
2018
Correction to: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes.
Current diabetes reports.
18(10)
[DOI] 10.1007/s11892-018-1068-3.
[PMID] 30173405.
2018
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles
Diabetes.
67(4):697-703
[DOI] 10.2337/db17-0937.
[PMID] 29343548.
2018
Mitochondrial Reactive Oxygen Species and Type 1 Diabetes.
Antioxidants & redox signaling.
29(14):1361-1372
[DOI] 10.1089/ars.2017.7346.
[PMID] 29295631.
2018
Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-03367-w.
[PMID] 29491378.
2018
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of
Chemical science.
9(34):6944-6951
[DOI] 10.1039/c8sc02680g.
[PMID] 30210768.
2018
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.01053.
[PMID] 29868014.
2018
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.
Nature genetics.
50(11):1574-1583
[DOI] 10.1038/s41588-018-0223-8.
[PMID] 30275530.
2018
The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.
Frontiers in endocrinology.
9
[DOI] 10.3389/fendo.2018.00051.
[PMID] 29527189.
2017
Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes.
Frontiers in immunology.
8
[DOI] 10.3389/fimmu.2017.01313.
[PMID] 29123516.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine.
23(8)
[DOI] 10.1038/nm0817-1004a.
[PMID] 28777787.
2017
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine.
23(2)
[DOI] 10.1038/nm0217-264a.
[PMID] 28170374.
2017
Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications.
8
[DOI] 10.1038/ncomms16143.
[PMID] 31305776.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research.
77(3):672-683
[DOI] 10.1158/0008-5472.CAN-16-1765.
[PMID] 27864347.
2017
Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.
Diabetes.
66(3):710-721
[DOI] 10.2337/db16-0846.
[PMID] 27920091.
2017
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
Diabetes.
66(3):722-734
[DOI] 10.2337/db16-1025.
[PMID] 27920090.
2017
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications.
8
[DOI] 10.1038/ncomms14477.
[PMID] 28205519.
2017
T cells display mitochondria hyperpolarization in human type 1 diabetes.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-11056-9.
[PMID] 28883439.
2017
The Type 1 Diabetes-Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice.
Journal of immunology (Baltimore, Md. : 1950).
199(12):3991-4000
[DOI] 10.4049/jimmunol.1602037.
[PMID] 29109122.
2017
Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway
Diabetes.
66(12):3061-3071
[DOI] 10.2337/db17-0106.
[PMID] 28877912.
2017
Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment.
Frontiers in endocrinology.
8
[DOI] 10.3389/fendo.2017.00232.
[PMID] 28959234.
2016
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine.
22(12):1482-1487
[DOI] 10.1038/nm.4203.
[PMID] 27798614.
2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes.
65(12):3765-3775
[PMID] 27669730.
2016
Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy.
Journal for immunotherapy of cancer.
4
[DOI] 10.1186/s40425-016-0196-z.
[PMID] 28031819.
2016
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
Diabetologia.
59(11):2448-2458
[DOI] 10.1007/s00125-016-4067-4.
[PMID] 27506584.
2016
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.
Clinical and experimental immunology.
183(3):350-7
[DOI] 10.1111/cei.12731.
[PMID] 26462724.
2016
Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study.
Scientific reports.
6
[DOI] 10.1038/srep31479.
[PMID] 27558530.
2015
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
Diabetes.
64(11):3885-90
[DOI] 10.2337/db15-0449.
[PMID] 26216853.
2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation.
125(1):448-55
[DOI] 10.1172/JCI78492.
[PMID] 25500887.
2015
Association of the mt-ND2 5178A/C polymorphism with Parkinson’s disease.
Neuroscience letters.
587:98-101
[DOI] 10.1016/j.neulet.2014.12.005.
[PMID] 25511548.
2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes.
64(11):3873-84
[DOI] 10.2337/db15-0164.
[PMID] 26185279.
2015
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.
American journal of physiology. Regulatory, integrative and comparative physiology.
309(5):R525-34
[DOI] 10.1152/ajpregu.00544.2014.
[PMID] 26084699.
2015
Efficient generation of human IgA monoclonal antibodies.
Journal of immunological methods.
422:102-10
[DOI] 10.1016/j.jim.2015.04.010.
[PMID] 25910833.
2015
How the location of superoxide generation influences the β-cell response to nitric oxide.
The Journal of biological chemistry.
290(12):7952-60
[DOI] 10.1074/jbc.M114.627869.
[PMID] 25648890.
2015
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells.
Journal of proteomics & bioinformatics.
8(6):126-132
[PMID] 26401069.
2015
Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.
Diabetes.
64(12):4171-83
[DOI] 10.2337/db15-0546.
[PMID] 26269022.
2015
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.).
67(1):225-37
[DOI] 10.1002/art.38882.
[PMID] 25252121.
2015
Reply to Gurgul-Convey and Lenzen: Cytokines, nitric oxide, and β-cells.
The Journal of biological chemistry.
290(16)
[PMID] 26065037.
2015
Repurposed biological scaffolds: kidney to pancreas.
Organogenesis.
11(2):47-57
[DOI] 10.1080/15476278.2015.1067354.
[PMID] 26252820.
2015
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.
BMC biochemistry.
16
[DOI] 10.1186/s12858-015-0051-8.
[PMID] 26358560.
2015
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.
Journal of immunology (Baltimore, Md. : 1950).
194(3):1169-77
[DOI] 10.4049/jimmunol.1302676.
[PMID] 25548220.
2014
In search of a surrogate: engineering human beta cell lines for therapy.
Trends in endocrinology and metabolism: TEM.
25(8):378-80
[DOI] 10.1016/j.tem.2014.05.006.
[PMID] 24958526.
2014
Metabolic abnormalities in the pathogenesis of type 1 diabetes.
Current diabetes reports.
14(9)
[DOI] 10.1007/s11892-014-0519-8.
[PMID] 25023213.
2014
Use of chemical probes to detect mitochondrial ROS by flow cytometry and spectrofluorometry.
Methods in enzymology.
542:223-41
[DOI] 10.1016/B978-0-12-416618-9.00012-1.
[PMID] 24862269.
2013
Do β-cells generate peroxynitrite in response to cytokine treatment?
The Journal of biological chemistry.
288(51):36567-78
[DOI] 10.1074/jbc.M113.522243.
[PMID] 24194521.
2012
Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.
The review of diabetic studies : RDS.
9(4):169-87
[DOI] 10.1900/RDS.2012.9.169.
[PMID] 23804259.
2012
Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines.
European journal of clinical investigation.
42(11):1244-51
[DOI] 10.1111/j.1365-2362.2012.02711.x.
[PMID] 22924552.
2012
Inherited β-cell dysfunction in lean individuals with type 2 diabetes.
Diabetes.
61(7):1659-60
[DOI] 10.2337/db12-0373.
[PMID] 22723272.
2012
Oxidative stress and beta cell dysfunction.
Methods in molecular biology (Clifton, N.J.).
900:347-62
[DOI] 10.1007/978-1-60761-720-4_17.
[PMID] 22933078.
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950).
188(8):4113-21
[DOI] 10.4049/jimmunol.1103113.
[PMID] 22422888.
2012
The use of leptin as treatment for type 1 diabetes mellitus: counterpoint.
Pediatric diabetes.
13(1):74-6
[DOI] 10.1111/j.1399-5448.2011.00796.x.
[PMID] 21884562.
2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity.
79(7):2746-54
[DOI] 10.1128/IAI.01291-10.
[PMID] 21518789.
2011
Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.
Biochimica et biophysica acta.
1812(11):1532-41
[DOI] 10.1016/j.bbadis.2011.07.016.
[PMID] 21839170.
2011
Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.
Molecular genetics and metabolism.
104(3):255-60
[DOI] 10.1016/j.ymgme.2011.07.023.
[PMID] 21846590.
2011
Methods to assess beta cell death mediated by cytotoxic T lymphocytes.
Journal of visualized experiments : JoVE.
(52)
[DOI] 10.3791/2724.
[PMID] 21712795.
2011
mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.
Diabetes.
60(1):355-9
[DOI] 10.2337/db10-1241.
[PMID] 20980458.
2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Journal of immunology (Baltimore, Md. : 1950).
187(2):911-8
[DOI] 10.4049/jimmunol.1100588.
[PMID] 21690321.
2011
Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes.
60(8):2086-91
[DOI] 10.2337/db11-0373.
[PMID] 21659497.
2011
Role of genetics in resistance to type 1 diabetes.
Diabetes/metabolism research and reviews.
27(8):849-53
[DOI] 10.1002/dmrr.1260.
[PMID] 22069272.
2011
Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.
PloS one.
6(6)
[DOI] 10.1371/journal.pone.0020617.
[PMID] 21738580.
2011
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Journal of immunology (Baltimore, Md. : 1950).
186(1):195-202
[DOI] 10.4049/jimmunol.1002104.
[PMID] 21106855.
2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Diabetes.
60(8):2144-51
[DOI] 10.2337/db10-1222.
[PMID] 21715554.
2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Diabetologia.
54(9):2232-6
[DOI] 10.1007/s00125-011-2244-z.
[PMID] 21773685.
2010
Attacking the source: anti-PDX-1 responses in type 1 diabetes.
Laboratory investigation; a journal of technical methods and pathology.
90(1):6-8
[DOI] 10.1038/labinvest.2009.121.
[PMID] 20038945.
2010
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.
Journal of immunology (Baltimore, Md. : 1950).
185(9):5247-58
[DOI] 10.4049/jimmunol.1001472.
[PMID] 20881184.
2010
Use of nonobese diabetic mice to understand human type 1 diabetes.
Endocrinology and metabolism clinics of North America.
39(3):541-61
[DOI] 10.1016/j.ecl.2010.05.001.
[PMID] 20723819.
2009
A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
150B(7):998-1006
[DOI] 10.1002/ajmg.b.30956.
[PMID] 19319892.
2009
Chapter 24 Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production.
Methods in enzymology.
456:439-57
[DOI] 10.1016/S0076-6879(08)04424-8.
[PMID] 19348903.
2009
Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter.
Cloning and stem cells.
11(2):245-57
[DOI] 10.1089/clo.2008.0074.
[PMID] 19508115.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes.
58(10):2277-84
[DOI] 10.2337/db09-0557.
[PMID] 19628781.
2009
MerTK regulates thymic selection of autoreactive T cells.
Proceedings of the National Academy of Sciences of the United States of America.
106(12):4810-5
[DOI] 10.1073/pnas.0900683106.
[PMID] 19251650.
2009
Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice.
Circulation research.
105(3):287-94
[DOI] 10.1161/CIRCRESAHA.109.193995.
[PMID] 19423844.
2008
Commonalities of genetic resistance to spontaneous autoimmune and free radical–mediated diabetes.
Free radical biology & medicine.
45(9):1263-70
[DOI] 10.1016/j.freeradbiomed.2008.07.020.
[PMID] 18718526.
2008
MerTK is required for apoptotic cell-induced T cell tolerance.
The Journal of experimental medicine.
205(1):219-32
[DOI] 10.1084/jem.20062293.
[PMID] 18195070.
2008
mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.
The Journal of biological chemistry.
283(16):10690-7
[DOI] 10.1074/jbc.M708801200.
[PMID] 18281288.
2008
Role of increased ROS dissipation in prevention of T1D.
Annals of the New York Academy of Sciences.
1150:157-66
[DOI] 10.1196/annals.1447.045.
[PMID] 19120287.
2007
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.
Blood.
109(2):653-60
[PMID] 17008547.
2007
Autoreactive T-cell responses: new technology in pursuit of an old nemesis.
Pediatric diabetes.
8(5):249-51
[PMID] 17850466.
2007
Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production.
The Journal of biological chemistry.
282(8):5171-9
[PMID] 17189252.
2006
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950).
176(5):3257-65
[PMID] 16493087.
2006
Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility.
Diabetes.
55(12):3455-62
[PMID] 17130492.
2005
DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice.
Gene therapy.
12(23):1679-85
[PMID] 16107864.
2005
Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.
Diabetes.
54(5):1603-6
[PMID] 15855353.
2005
Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction.
Journal of immunology (Baltimore, Md. : 1950).
175(2):1248-56
[PMID] 16002729.
2005
mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes.
Diabetologia.
48(2):261-7
[PMID] 15692809.
2005
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.
The Journal of biological chemistry.
280(16):15727-34
[PMID] 15705591.
2005
Utility of murine models for the study of spontaneous autoimmune type 1 diabetes.
Pediatric diabetes.
6(3):165-77
[PMID] 16109074.
2004
ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential.
Diabetes.
53 Suppl 1:S125-9
[PMID] 14749277.
2004
Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse.
Methods in molecular medicine.
102:213-25
[PMID] 15286388.
2003
Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.
Immunogenetics.
55(7):491-6
[PMID] 14513297.
2003
Reduced thymic expression of islet antigen contributes to loss of self-tolerance.
Annals of the New York Academy of Sciences.
1005:412-7
[PMID] 14679103.
2002
Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice.
Free radical biology & medicine.
32(8):744-51
[PMID] 11937300.
2002
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.
Transplantation.
73(8):1333-6
[PMID] 11981430.
2002
Rodent models for the study of type 2 diabetes in children (juvenile diabesity).
Pediatric diabetes.
3(3):163-73
[PMID] 15016157.
2001
Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants.
Proceedings of the National Academy of Sciences of the United States of America.
98(1):235-40
[PMID] 11136257.
2000
Attenuation of circadian rhythms of food intake and respiration in aging diabetes-prone BHE/Cdb rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
279(1):R230-8
[PMID] 10896886.
2000
Reevaluation of the major histocompatibility complex genes of the NOD-progenitor CTS/Shi strain.
Diabetes.
49(1):131-4
[PMID] 10615961.
1999
Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan-susceptible mice.
Free radical biology & medicine.
27(3-4):449-55
[PMID] 10468221.
1999
MHC characterization of ALR and ALS mice: respective similarities to the NOD and NON strains.
Immunogenetics.
49(7-8):722-6
[PMID] 10369935.
1999
Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.
Diabetes.
48(11):2189-96
[PMID] 10535453.
1999
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
Diabetes.
48(3):543-51
[PMID] 10078554.
1995
A point mutation in the mitochondrial DNA of diabetes-prone BHE/cdb rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
9(15):1638-42
[PMID] 8529844.
Grants
Nov 2023
ACTIVE
Synthetic Multivalent Galectin Assemblies as Anti-Inflammatory Therapies
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2023
ACTIVE
Specific senescence detection in pancreatic islets
Role: Consultant
Funding: NATL INST OF HLTH NIA
Jul 2023
ACTIVE
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
Role: Principal Investigator
Funding: UNIV OF KANSAS MEDICAL CTR
via NATL INST OF HLTH NIDDK
Jun 2023
ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Feb 2023
ACTIVE
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2022
– Jul 2023
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID, & Pharmacology
Role: Project Manager
Funding: ADV REGENERATIVE MANUFACTURING INST
via US ARMY RESEARCH LABORATORY
Sep 2021
ACTIVE
Engineering a dynamic three-dimensional in vitro platform for the investigation of human Type 1 Diabetes immunopathogenesis
Role: Other
Funding: NATL INST OF HLTH NIDDK
May 2021
ACTIVE
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Mar 2021
– Jul 2023
Immunocore ImmTAAI technology and its potential use to treat type 1 diabetes autoimmunity
Role: Other
Funding: IMMUNOCORE LIMITED
Oct 2020
ACTIVE
Multi-omic 3D tissue maps for a Human BioMolecular Atlas
Role: Principal Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Sep 2020
– Dec 2022
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
Role: Principal Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM
via NATL INST OF HLTH NIDDK
Sep 2020
– Dec 2022
Engineered tolerogenic exosomes for treating type 1 diabetes autoimmunity
Role: Other
Funding: NATL INST OF HLTH NIDDK
Feb 2020
ACTIVE
Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes
Role: Principal Investigator
Funding: BATTELLE MEMORIAL INST
via NATL INST OF HLTH NIDDK
Sep 2019
ACTIVE
Evaluation of safety, tolerability and immunological responses to Lactobacillus johnsonii N6.2 supplementation in adults with Diabetes type 1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2019
ACTIVE
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2019
– Jul 2021
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2019
– Jan 2022
The Role of IFN? supplementation in T cell effector function in Patients with Chronic Granulomatous Disease
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
via HORIZON THERAPEUTICS
Jun 2018
– May 2023
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2018
– Sep 2023
Network for Pancreatic Organ Donors – nPOD
Role: Co-Investigator
Funding: JDRF
Jan 2018
– Sep 2023
Collaborative Type 1 Diabetes Research Project: The Network for Pancreatic Organ donors with Diabetes (nPOD)
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Apr 2017
– Mar 2024
Metabolic Origins of Nonalcoholic Steatohepatitis
Role: Principal Investigator
Funding: UNIV OF MARYLAND COLLEGE PARK
via NATL INST OF HLTH NIDDK
Apr 2017
– Mar 2021
Advanced Liver 3-D Tissue Models for Drug Development Applications to Support Toxicology, Drug Metabolism, Target ID & Pharmacology
Role: Faculty
Funding: ADV REGENERATIVE MANUFACTURING INST
via US ARMY RESEARCH LABORATORY
Oct 2016
– Jun 2019
Serum protein biomarkers for predicting type 1 diabetes development
Role: Principal Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Aug 2016
– Jul 2019
Insulin Specific T and B cells in Type 1 Diabetes
Role: Principal Investigator
Funding: UNIV OF COLORADO DENVER & ANSCHUTZ MED
via NATL INST OF HLTH NIDDK
May 2015
– May 2019
Type 1 IFN in Type 1 Diabetes: Influencing Beta-Cell and CD8+ T cell interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2015
– May 2017
Therapeutic Targeting of immune metabolism
Role: Project Manager
Funding: UF DIV OF SPONSORED RESEARCH
Jan 2015
– Aug 2018
Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
Role: Principal Investigator
Funding: PACIFIC NW NATL LAB
via NATL INST OF HLTH NIDDK
Jan 2015
– Dec 2017
Mechanisms of Type 1 Diabetes Remission Induced by Combination Therapy
Role: Principal Investigator
Funding: AMER DIABETES ASSOCIATION
Sep 2014
– Jun 2019
Genetic Regulation of Human Beta Cell Destruction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2014
– Aug 2018
Defining Islet Heterogeneity Using Single Islet Transcriptomics
Role: Co-Investigator
Funding: UNIV OF TENNESSEE
via NATL INST OF HLTH NIDDK
May 2013
– Jun 2018
Immune Function and the Progression to Type 1 Diabetes
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jun 2012
– May 2017
mt-Nd2 and Resistance to Autoimmune Diseases
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Apr 2011
– Jun 2022
Sebastian Family Chair in Diabetes Research
Role: Principal Investigator
Funding: UF FOUNDATION
Contact Details
Phones:
- Business:
- (352) 273-9269
Emails:
- Business:
- cxm@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100275
GAINESVILLE FL 32610 - Business Street:
-
5TH FLOOR
5TH FLOOR J597
BIOMEDICAL SCIENCES BUILDING
GAINESVILLE FL 326110001