Petr Starostik, M.D.
PRG DIR & CLIN PROF
Department:
MD-PATHOLOGY-GENERAL
Business Phone:
(352) 265-9900
Business Email:
starostik@pathology.ufl.edu
Teaching Profile
Courses Taught
2019
PHA6136 Clinical Applications of Precision Medicine: Oncology
2021
PHA6935 Selected Topics in Pharmacy
Board Certifications
-
Clinical PathologyAmerican Board of Pathology
-
HematopathologyAmerican Board of Pathology
-
Molecular Genetic PathologyAmerican Board of Pathology
Clinical Profile
Director, Molecular Pathology
Subspecialties
- Clinical Pathology
Publications
2023
Automated HL7v2 LRI informatics framework for streamlining genomics-EHR data integration.
Journal of pathology informatics.
14
[DOI] 10.1016/j.jpi.2023.100330.
[PMID] 37719179.
2023
Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report.
Blood advances.
7(16):4599-4607
[DOI] 10.1182/bloodadvances.2023010149.
[PMID] 37236162.
2023
CYP2D6-guided opioid therapy for adults with cancer pain: A randomized implementation clinical trial.
Pharmacotherapy.
43(12):1286-1296
[DOI] 10.1002/phar.2875.
[PMID] 37698371.
2023
Defining critical illness using immunological endotypes in patients with and without of sepsis: A cohort study.
Research square.
[DOI] 10.21203/rs.3.rs-2874506/v1.
[PMID] 37214996.
2023
Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study.
Critical care (London, England).
27(1)
[DOI] 10.1186/s13054-023-04571-x.
[PMID] 37474944.
2023
Reimbursement of pharmacogenetic tests at a tertiary academic medical center in the United States.
Frontiers in pharmacology.
14
[DOI] 10.3389/fphar.2023.1179364.
[PMID] 37645439.
2022
Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project.
The Journal of molecular diagnostics : JMD.
24(10):1079-1088
[DOI] 10.1016/j.jmoldx.2022.06.008.
[PMID] 35931342.
2022
Deleterious mutations in esophageal carcinoma cuniculatum detected by next generation sequencing.
International journal of clinical and experimental pathology.
15(1):38-45
[PMID] 35145582.
2022
Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension.
Contemporary clinical trials.
119
[DOI] 10.1016/j.cct.2022.106813.
[PMID] 35660539.
2022
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients.
JAMA network open.
5(7)
[DOI] 10.1001/jamanetworkopen.2022.21520.
[PMID] 35819783.
2022
GATM-Mediated Creatine Biosynthesis Enables Maintenance of FLT3-ITD-Mutant Acute Myeloid Leukemia.
Molecular cancer research : MCR.
20(2):293-304
[DOI] 10.1158/1541-7786.MCR-21-0314.
[PMID] 34635505.
2022
Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-Site, Real-World Investigation.
Clinical pharmacology and therapeutics.
112(1):146-155
[DOI] 10.1002/cpt.2612.
[PMID] 35429163.
2022
Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators.
Clinical and translational science.
15(10):2479-2492
[DOI] 10.1111/cts.13376.
[PMID] 35899435.
2022
Low-frequency variants in mildly symptomatic vaccine breakthrough infections presents a doubled-edged sword.
Journal of medical virology.
94(7):3192-3202
[DOI] 10.1002/jmv.27726.
[PMID] 35307848.
2022
Severe Acute Respiratory Syndrome Coronavirus 2 Delta Vaccine Breakthrough Transmissibility in Alachua County, Florida.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
75(9):1618-1627
[DOI] 10.1093/cid/ciac197.
[PMID] 35271704.
2022
Synchronous Basal Cell Carcinoma and Squamous Cell Carcinoma of Nasal Vestibule With Novel Unique Variants Identified by Whole-exome Sequencing.
In vivo (Athens, Greece).
36(1):251-257
[DOI] 10.21873/invivo.12698.
[PMID] 34972722.
2021
A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.
Genetics in medicine : official journal of the American College of Medical Genetics.
23(4):621-628
[DOI] 10.1038/s41436-020-01050-4.
[PMID] 33420349.
2021
A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients.
Critical care explorations.
3(10)
[DOI] 10.1097/CCE.0000000000000554.
[PMID] 34671746.
2021
Mixed acinar-neuroendocrine carcinoma with amphicrine features of the pancreas: Two rare cases with diffuse co-expression of acinar and neuroendocrine markers.
Pathology international.
71(7):485-487
[DOI] 10.1111/pin.13105.
[PMID] 34000758.
2021
Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.792448.
[PMID] 34956225.
2021
Pathology Informatics and Robotics Strategies for Improving Efficiency of COVID-19 Pooled Testing.
Academic pathology.
8
[DOI] 10.1177/23742895211020485.
[PMID] 34189259.
2021
The Hologic Aptima SARS-CoV-2 assay enables high ratio pooling saving reagents and improving turnaround time.
Journal of clinical laboratory analysis.
35(9)
[DOI] 10.1002/jcla.23888.
[PMID] 34213803.
2020
Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
26(2):439-449
[DOI] 10.1158/1078-0432.CCR-19-1667.
[PMID] 31548343.
2020
How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
Clinical pharmacology and therapeutics.
108(3):557-565
[DOI] 10.1002/cpt.1912.
[PMID] 32460360.
2020
Malignant round cell tumor with SS18-POU5F1 fusion: is it a myoepithelial neoplasm, a synovial sarcoma or a new entity?
Histopathology.
77(4):681-684
[DOI] 10.1111/his.14171.
[PMID] 32516451.
2020
Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.
JAMIA open.
3(4):523-529
[DOI] 10.1093/jamiaopen/ooaa055.
[PMID] 33754137.
2020
SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Review of Literature.
International journal of surgical pathology.
28(1):102-108
[DOI] 10.1177/1066896919865944.
[PMID] 31382829.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(8):1842-1850
[DOI] 10.1038/s41436-018-0431-8.
[PMID] 30670877.
2019
Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls.
The Journal of surgical research.
239:76-82
[DOI] 10.1016/j.jss.2019.01.062.
[PMID] 30822694.
2019
Mapping the Mutation Landscape of Colorectal Cancer.
The American journal of the medical sciences.
358(5):313-314
[DOI] 10.1016/j.amjms.2019.08.004.
[PMID] 31655711.
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine.
16(1)
[DOI] 10.1186/s12967-018-1469-8.
[PMID] 29642909.
2018
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials.
68:7-13
[DOI] 10.1016/j.cct.2018.03.001.
[PMID] 29535047.
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.
11(2):181-191
[DOI] 10.1016/j.jcin.2017.07.022.
[PMID] 29102571.
2018
Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.
Genetic testing and molecular biomarkers.
22(4):266-269
[DOI] 10.1089/gtmb.2017.0261.
[PMID] 29641284.
2017
Clinical mutation assay of tumors: new developments.
Anti-cancer drugs.
28(1):1-10
[PMID] 27575332.
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics.
18(5):421-426
[DOI] 10.2217/pgs-2017-0028.
[PMID] 28346068.
2016
Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML.
Case reports in hematology.
2016
[DOI] 10.1155/2016/1259759.
[PMID] 28127477.
2015
Routine Clinical Mutation Profiling of Non-Small Cell Lung Cancer Using Next-Generation Sequencing.
Archives of pathology & laboratory medicine.
139(7):913-21
[DOI] 10.5858/arpa.2014-0095-OA.
[PMID] 26125431.
2014
Deletion and deletion/insertion mutations in the juxtamembrane domain of the FLT3 gene in adult acute myeloid leukemia.
Leukemia research reports.
3(2):86-9
[DOI] 10.1016/j.lrr.2013.09.003.
[PMID] 25379410.
2013
Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute – Waldenström Macroglobulinemia 1.
Leukemia & lymphoma.
54(2):387-96
[DOI] 10.3109/10428194.2012.713481.
[PMID] 22812491.
2013
Phase II trial of clofarabine and daunorubicin as induction therapy for acute myeloid leukemia patients greater than or equal to 60 years of age.
Leukemia research.
37(11):1468-71
[DOI] 10.1016/j.leukres.2013.07.036.
[PMID] 24011826.
2013
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.
32(1):71-5
[DOI] 10.1097/PGP.0b013e3182566552.
[PMID] 23202784.
2012
Monoallelic and biallelic deletions of 13q14.3 in chronic lymphocytic leukemia: FISH vs miRNA RT-qPCR detection.
American journal of clinical pathology.
137(4):641-6
[DOI] 10.1309/AJCPP31FSSRQTTAQ.
[PMID] 22431542.
2011
ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ERBB2 gene.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
24(8):1055-9
[DOI] 10.1038/modpathol.2011.64.
[PMID] 21499233.
2011
Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia.
Leukemia research.
35(5):579-84
[DOI] 10.1016/j.leukres.2010.10.020.
[PMID] 21176961.
2010
Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse.
Cancer genetics and cytogenetics.
202(2):101-7
[DOI] 10.1016/j.cancergencyto.2010.07.117.
[PMID] 20875872.
2010
Multiparameter flow cytometry for the diagnosis and monitoring of small GPI-deficient cellular populations.
Cytometry. Part B, Clinical cytometry.
78(5):348-56
[DOI] 10.1002/cyto.b.20519.
[PMID] 20533383.
2009
Microsatellite instability in large cell neuroendocrine carcinoma of the female genital tract.
Histopathology.
55(5):621-5
[DOI] 10.1111/j.1365-2559.2009.03410.x.
[PMID] 19912372.
2008
Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels.
Clinical cancer research : an official journal of the American Association for Cancer Research.
14(5):1561-70
[DOI] 10.1158/1078-0432.CCR-07-1254.
[PMID] 18316581.
2007
Increased frequency of uridine diphosphate glucuronosyltransferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities.
Clinical colorectal cancer.
6(8):583-7
[PMID] 17681105.
2007
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy.
Leukemia & lymphoma.
48(5):1053-6
[PMID] 17487757.
2006
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
24(34):5343-9
[PMID] 17088571.
2005
Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma.
Virchows Archiv : an international journal of pathology.
446(4):416-20
[PMID] 15756589.
2005
CD117+ small cell lung cancer lacks the asp 816–>val point mutation in exon 17.
Histopathology.
47(5):517-22
[PMID] 16242000.
2003
Allelic losses on chromosome 6q25 in Hodgkin and Reed Sternberg cells.
Cancer research.
63(10):2606-9
[PMID] 12750286.
2003
Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas.
Cancer research.
63(13):3708-15
[PMID] 12839963.
2003
High frequency of genetic aberrations in enteropathy-type T-cell lymphoma.
Laboratory investigation; a journal of technical methods and pathology.
83(10):1509-16
[PMID] 14563952.
2003
Human ependymomas reveal frequent deletions on chromosomes 6 and 9.
Acta neuropathologica.
106(4):357-62
[PMID] 12898154.
2003
Semiquantitative and qualitative assessment of B-lymphocyte V H repertoire by a fluorescent multiplex PCR.
Journal of immunological methods.
276(1-2):121-7
[PMID] 12738364.
2002
A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency.
European journal of human genetics : EJHG.
10(9):499-504
[PMID] 12173025.
2002
Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified.
American journal of clinical pathology.
117(3):368-79
[PMID] 11888076.
2002
Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways.
Blood.
99(1):3-9
[PMID] 11756145.
2002
Loss of heterozygosity on chromosome 22 in human ependymomas.
Acta neuropathologica.
103(4):415-20
[PMID] 11904762.
2002
Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells.
International journal of cancer.
97(2):205-10
[PMID] 11774265.
2002
Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm.
The American journal of surgical pathology.
26(1):119-24
[PMID] 11756779.
2001
Diagnosis of microsatellite instability-positive colorectal cancer.
Expert review of molecular diagnostics.
1(1):71-80
[PMID] 11901802.
2001
Loss of Fas (CD95/APO-1) regulatory function is an important step in early MALT-type lymphoma development.
Laboratory investigation; a journal of technical methods and pathology.
81(7):977-86
[PMID] 11454987.
2001
Primary low-grade B cell non-Hodgkin’s lymphoma of MALT type simultaneously arising in the colon and in the lung: report of a case.
Diseases of the colon and rectum.
44(3):448-52
[PMID] 11289295.
2001
Thymic epithelial tumors can develop along two different pathogenetic pathways.
The American journal of pathology.
159(5):1853-60
[PMID] 11696445.
2000
Deletions in the 13q14 locus in adult lymphoblastic leukemia: rate of incidence and relevance.
Cancer.
88(6):1359-64
[PMID] 10717617.
2000
Genetic aberrations common in gastric high-grade large B-cell lymphoma.
Blood.
95(4):1180-7
[PMID] 10666188.
2000
Genetic imbalances in primary gastric diffuse large B-cell lymphomas: comparison of comparative genomic hybridization, microsatellite, and cytogenetic analysis.
Diagnostic molecular pathology : the American journal of surgical pathology, part B.
9(1):58-65
[PMID] 10718214.
2000
Histopathology and molecular pathology of synovial B-lymphocytes in rheumatoid arthritis.
Histology and histopathology.
15(3):791-8
[DOI] 10.14670/HH-15.791.
[PMID] 10963123.
2000
The role of microsatellite instability in gastric low- and high-grade lymphoma development.
The American journal of pathology.
157(4):1129-36
[PMID] 11021817.
1999
ATM mutations in B-cell chronic lymphocytic leukemia.
Cancer research.
59(1):24-7
[PMID] 9892178.
1999
Infection with parapoxvirus induces CD30-positive cutaneous infiltrates in humans.
Journal of cutaneous pathology.
26(10):520-2
[PMID] 10599944.
1999
Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response.
Laboratory investigation; a journal of technical methods and pathology.
79(11):1377-84
[PMID] 10576208.
1999
The prognostic significance of 13q14 deletions in chronic lymphocytic leukemia.
Leukemia research.
23(9):795-801
[PMID] 10475618.
1999
Use of peripheral blood blasts vs bone marrow blasts for diagnosis of acute leukemia.
American journal of clinical pathology.
111(6):733-40
[PMID] 10361507.
1998
Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia.
Cancer research.
58(20):4552-7
[PMID] 9788599.
1996
The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif.
Molecular and cellular biology.
16(12):7173-81
[PMID] 8943373.
1996
Transcriptional repression and growth suppression by the p107 pocket protein.
Molecular and cellular biology.
16(7):3606-14
[PMID] 8668177.
Grants
Aug 2022
ACTIVE
Investigating miR-9-5p and its targets as interventional and clinicopathologic predictors of laryngeal cancer racial disparate outcomes
Role: Other
Funding: US ARMY MED RES ACQUISITION
Sep 2021
ACTIVE
Preemptive pharmacogenetic testing in medically underserved populations
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Feb 2021
– May 2022
Transcriptomic Analysis of s63 as a Prognostic Score of FDY-5301 Effectiveness in Trauma Patients A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Intravenous FDY-5301 for the Prevention and Treatment of ICU Acquired Weakness in Major Trau
Role: Co-Investigator
Funding: FARADAY PHARMACEUTICALS
Jul 2020
– Jul 2021
White House Study: Evaluate COVID-19 Detection Technology
Role: Co-Investigator
Funding: US DEPT OF HLTH AND HUMAN SER
Jul 2020
ACTIVE
Precision antiplatelet therapy after percutaneous coronary intervention
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Jul 2020
ACTIVE
Personalized dosing of dichloroacetate for the treatment of rare and common diseases
Role: Project Manager
Funding: MEDOSOME BIOTEC
via NATL INST OF HLTH NICHD
Jun 2020
ACTIVE
RADIANT Core Laboratory Proposal 2020-21
Role: Co-Investigator
Funding: UNIV OF CHICAGO
via NATL INST OF HLTH NIDDK
Aug 2019
– Sep 2021
BARDA DRIVe HostDx Sepsis UF (Clinical Validation and Implementation of HostDX Sepsis on NanoString)
Role: Co-Investigator
Funding: INFLAMMATIX
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Sep 2018
ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Jun 2013
– Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Education
Fellowship – Hematophathy
1997
·
Anderson Cancer Center
Residency – Pathology
1995
·
Washington University
Medical Degree
1982
·
Vienna University School of Medicine, Vienna, Austria
Contact Details
Phones:
- Business:
- (352) 265-9900
Emails:
- Business:
- starostik@pathology.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100275
GAINESVILLE FL 32610