Naohiro Terada

Naohiro Terada,

Professor

Department: MD-PATHOLOGY
Business Phone: (352) 392-2696
Business Email: terada@pathology.ufl.edu

About Naohiro Terada

1981-1987 Resident/Staff, Osaka University Hospital etc; 1987-1989 Research Associate of Pediatrics (HEM/ONC), Osaka University; 1989-1992 Research Associate of Pediatrics, National Jewish; 1992-1999 Assistant Faculty Member of Pediatrics, National Jewish; 1994-1999 Assistant Professor (Adjunct), Department of Pediatrics, University of Colorado; 2000-2001 Assistant Professor, Department of Pathology, University of Florida; 2001-2010 Associate Professor (Tenured), Department of Pathology, University of Florida; 2010-present Professor, Department of Pathology, University of Florida; 2019-present Specially Appointed Professor, Medical Education Center, Osaka University Faculty of Medicine

Teaching Profile

Courses Taught
2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2013,2015-2018
BCH7412 Epigenetics of Human Disease and Development
2018
GMS7980 Research for Doctoral Dissertation
2008-2016,2018
GMS6331 Stem Cell Biology
2014,2016-2018
GMS6421 Cell Biology
2009-2010
IDH4917 Undergrad Research
2007
GMS6335 Tissue Engineering
2007
GMS6336 Regenerative Medicine
2006
GMS6381 Spec Topics Pathology

Research Profile

Terada lab is interested in (1) pluripotent stem cell biology and its application to clinical translational research, and (2) the mitochondrial ATP trasnporters.

Areas of Interest
  • Mitochondria
  • Stem Cell biology

Publications

2021
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.737276. [PMID] 34858326.
2020
A hypertension patient-derived iPSC model demonstrates a role for G protein-coupled estrogen receptor in hypertension risk and development.
American journal of physiology. Cell physiology. 319(5):C825-C838 [DOI] 10.1152/ajpcell.00350.2019. [PMID] 32783656.
2020
Generation of Induced Pluripotent Stem Cells from a Female Patient with a Xq27.3-q28 Deletion to Establish Disease Models and Identify Therapies.
Cellular reprogramming. 22(4):179-188 [DOI] 10.1089/cell.2020.0012. [PMID] 32608992.
2020
High-efficiency protein delivery into transfection-recalcitrant cell types.
Biotechnology and bioengineering. 117(3):816-831 [DOI] 10.1002/bit.27245. [PMID] 31814110.
2019
Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.
Stem cell research. 37 [DOI] 10.1016/j.scr.2019.101434. [PMID] 30999275.
2019
Extramitochondrial cardiolipin suggests a novel function of mitochondria in spermatogenesis.
The Journal of cell biology. 218(5):1491-1502 [DOI] 10.1083/jcb.201808131. [PMID] 30914420.
2019
H+ transport is an integral function of the mitochondrial ADP/ATP carrier.
Nature. 571(7766):515-520 [DOI] 10.1038/s41586-019-1400-3. [PMID] 31341297.
2019
Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.
Science advances. 5(8) [DOI] 10.1126/sciadv.aaw4597. [PMID] 31489369.
2019
Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy.
Human molecular genetics. 28(14):2365-2377 [DOI] 10.1093/hmg/ddz064. [PMID] 31267131.
2018
Activation of p70S6 Kinase-1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair.
Stem cells translational medicine. 7(7):551-558 [DOI] 10.1002/sctm.17-0200. [PMID] 29730892.
2018
Bacterial type III secretion system as a protein delivery tool for a broad range of biomedical applications.
Biotechnology advances. 36(2):482-493 [DOI] 10.1016/j.biotechadv.2018.01.016. [PMID] 29409784.
2018
CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages.
Journal of leukocyte biology. 103(6):1225-40 [DOI] 10.1002/JLB.3MIA0917-352R. [PMID] 29437254.
2018
Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery.
PloS one. 13(3) [DOI] 10.1371/journal.pone.0194895. [PMID] 29579079.
2018
Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies.
Current stem cell reports. 4(4):299-309 [DOI] 10.1007/s40778-018-0145-5. [PMID] 30524939.
2018
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-23436-w. [PMID] 29567975.
2018
Therapeutic Genome Editing for Myotonic Dystrophy Type 1 Using CRISPR/Cas9.
Molecular therapy : the journal of the American Society of Gene Therapy. 26(11):2617-2630 [DOI] 10.1016/j.ymthe.2018.09.003. [PMID] 30274788.
2017
A pathologist’s perspective on induced pluripotent stem cells.
Laboratory investigation; a journal of technical methods and pathology. 97(10):1126-1132 [DOI] 10.1038/labinvest.2017.81. [PMID] 28759008.
2017
Concise Review: Induced Pluripotent Stem Cell Research in the Era of Precision Medicine.
Stem cells (Dayton, Ohio). 35(3):545-550 [DOI] 10.1002/stem.2570. [PMID] 28100040.
2017
Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications. 8 [DOI] 10.1038/ncomms16143. [PMID] 31305776.
2017
Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells.
Oncotarget. 8(17):28971-28989 [DOI] 10.18632/oncotarget.15952. [PMID] 28423644.
2017
Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.
Frontiers in endocrinology. 8 [DOI] 10.3389/fendo.2017.00276. [PMID] 29093700.
2017
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications. 8 [DOI] 10.1038/ncomms14477. [PMID] 28205519.
2017
New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.
Clinical pharmacology and therapeutics. 102(6):897-902 [DOI] 10.1002/cpt.755. [PMID] 28795399.
2016
Genome Therapy of Myotonic Dystrophy Type 1 iPS Cells for Development of Autologous Stem Cell Therapy.
Molecular therapy : the journal of the American Society of Gene Therapy. 24(8):1378-87 [DOI] 10.1038/mt.2016.97. [PMID] 27203440.
2016
HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.
Cell reports. 14(1):103-114 [DOI] 10.1016/j.celrep.2015.12.007. [PMID] 26725110.
2016
Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast.
Journal of biomolecular screening. 21(4):381-90 [DOI] 10.1177/1087057115624637. [PMID] 26746582.
2016
Influence of Amino Acid Metabolism on Embryonic Stem Cell Function and Differentiation.
Advances in nutrition (Bethesda, Md.). 7(4):780S-9S [DOI] 10.3945/an.115.011031. [PMID] 27422515.
2015
A practical guide to induced pluripotent stem cell research using patient samples.
Laboratory investigation; a journal of technical methods and pathology. 95(1):4-13 [DOI] 10.1038/labinvest.2014.104. [PMID] 25089770.
2015
Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.
Reproductive sciences (Thousand Oaks, Calif.). 22(2):250-7 [DOI] 10.1177/1933719114542026. [PMID] 25031318.
2015
Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors.
Scientific reports. 5 [DOI] 10.1038/srep15014. [PMID] 26449528.
2015
Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins.
Stem cells translational medicine. 4(8):913-26 [DOI] 10.5966/sctm.2015-0030. [PMID] 26062981.
2015
Electromyogram biofeedback training for daytime clenching and its effect on sleep bruxism.
Journal of oral rehabilitation. 42(2):83-9 [DOI] 10.1111/joor.12233. [PMID] 25256380.
2015
Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.
Stem cells (Dayton, Ohio). 33(6):1829-38 [DOI] 10.1002/stem.1970. [PMID] 25702800.
2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation. 22(9):1437-50 [DOI] 10.1038/cdd.2014.230. [PMID] 25613378.
2015
Regional Collaboration in Home Care Services.
Japan Medical Association journal : JMAJ. 58(1-2):10-4 [PMID] 26557455.
2015
Repurposed biological scaffolds: kidney to pancreas.
Organogenesis. 11(2):47-57 [DOI] 10.1080/15476278.2015.1067354. [PMID] 26252820.
2015
Vascular Smooth Muscle Cells From Hypertensive Patient-Derived Induced Pluripotent Stem Cells to Advance Hypertension Pharmacogenomics.
Stem cells translational medicine. 4(12):1380-90 [DOI] 10.5966/sctm.2015-0126. [PMID] 26494780.
2014
Bacterial delivery of TALEN proteins for human genome editing.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0091547. [PMID] 24618838.
2014
Bioengineered Pancreas: Human Insulin-Secreting Islet Cells in Vascularized Pig Kidney Scaffolds
Nephrology Dialysis Transplantation. 29(3)
2014
Generation of Vascular Cells From Patient Derived Ipsc To Model Hypertension
The FASEB's Journal. 28(1, S)
2014
In search of a surrogate: engineering human beta cell lines for therapy.
Trends in endocrinology and metabolism: TEM. 25(8):378-80 [DOI] 10.1016/j.tem.2014.05.006. [PMID] 24958526.
2014
Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system.
Microbiology (Reading, England). 160(Pt 7):1417-1426 [DOI] 10.1099/mic.0.078139-0. [PMID] 24699069.
2014
Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.
Human gene therapy methods. 25(1):72-82 [DOI] 10.1089/hgtb.2013.011. [PMID] 24191859.
2013
Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.
American journal of physiology. Endocrinology and metabolism. 305(3):E325-35 [DOI] 10.1152/ajpendo.00136.2013. [PMID] 23736538.
2013
Development of Cellular Models for Studying Pathogenetic Mechanisms of Arteriovenous Malformation Using Induced Pluripotent Stem Cells From a Mouse Model of Hereditary Hemorrhagic Telangiectasia (Hht)
Angiogenesis. 16:268-269
2013
Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein.
Cellular reprogramming. 15(2):117-25 [DOI] 10.1089/cell.2012.0058. [PMID] 23438194.
2013
E2f6-mediated repression of the meiotic Stag3 and Smc1β genes during early embryonic development requires Ezh2 and not the de novo methyltransferase Dnmt3b.
Epigenetics. 8(8):873-84 [DOI] 10.4161/epi.25522. [PMID] 23880518.
2013
Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro.
Journal of molecular neuroscience : MN. 51(2):237-48 [DOI] 10.1007/s12031-012-9930-2. [PMID] 23224816.
2013
Generation of neural cells from DM1 induced pluripotent stem cells as cellular model for the study of central nervous system neuropathogenesis.
Cellular reprogramming. 15(2):166-77 [DOI] 10.1089/cell.2012.0086. [PMID] 23550732.
2013
Identification of adenine nucleotide translocase 4 inhibitors by molecular docking.
Journal of molecular graphics & modelling. 45:173-9 [DOI] 10.1016/j.jmgm.2013.08.016. [PMID] 24056384.
2013
The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.
Journal of cell science. 126(Pt 16):3638-48 [DOI] 10.1242/jcs.124925. [PMID] 23750005.
2012
A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction.
Medical hypotheses. 79(5):673-7 [DOI] 10.1016/j.mehy.2012.08.006. [PMID] 22939314.
2012
Fibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors.
The Journal of biological chemistry. 287(36):30507-17 [DOI] 10.1074/jbc.M112.388181. [PMID] 22787153.
2012
High-order Ho multipoles in HoB2C2 observed with soft resonant x-ray diffraction.
Journal of physics. Condensed matter : an Institute of Physics journal. 24(7) [DOI] 10.1088/0953-8984/24/7/075602. [PMID] 22301486.
2012
Importance of culture conditions during the morula-to-blastocyst period on capacity of inner cell-mass cells of bovine blastocysts for establishment of self-renewing pluripotent cells.
Theriogenology. 78(6):1243-51.e1 [DOI] 10.1016/j.theriogenology.2012.05.020. [PMID] 22898023.
2012
JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma.
Oncogene. 31(25):3098-110 [DOI] 10.1038/onc.2011.475. [PMID] 22020339.
2012
Mouse stem cells seeded into decellularized rat kidney scaffolds endothelialize and remodel basement membranes.
Organogenesis. 8(2):49-55 [DOI] 10.4161/org.20209. [PMID] 22692231.
2011
An Ezh way to turn off Nanog.
Cell cycle (Georgetown, Tex.). 10(14):2253-4 [PMID] 21670594.
2011
Bacterial delivery of nuclear proteins into pluripotent and differentiated cells.
PloS one. 6(1) [DOI] 10.1371/journal.pone.0016465. [PMID] 21304583.
2011
Evolutionary genomics implies a specific function of Ant4 in mammalian and anole lizard male germ cells.
PloS one. 6(8) [DOI] 10.1371/journal.pone.0023122. [PMID] 21858006.
2011
Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0019250. [PMID] 21532989.
2011
Gelatinized copper-capillary alginate gel functions as an injectable tissue scaffolding system for stem cell transplants.
Journal of biomaterials science. Polymer edition. 22(12):1621-37 [DOI] 10.1163/092050610X519453. [PMID] 20699061.
2011
Induced pluripotent stem cells as a next-generation biomedical interface.
Laboratory investigation; a journal of technical methods and pathology. 91(7):972-7 [DOI] 10.1038/labinvest.2011.85. [PMID] 21555998.
2011
Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells.
PloS one. 6(12) [DOI] 10.1371/journal.pone.0029690. [PMID] 22220215.
2011
Synthetic small molecules for epigenetic activation of pluripotency genes in mouse embryonic fibroblasts.
Chembiochem : a European journal of chemical biology. 12(18):2822-8 [DOI] 10.1002/cbic.201100597. [PMID] 22038863.
2009
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding.
Molecular cancer research : MCR. 7(10):1622-34 [DOI] 10.1158/1541-7786.MCR-09-0018. [PMID] 19825994.
2009
Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.
Reproduction (Cambridge, England). 138(3):463-70 [DOI] 10.1530/REP-09-0201. [PMID] 19556438.
2009
Differential CpG island methylation of murine adenine nucleotide translocase genes.
Biochimica et biophysica acta. 1789(3):198-203 [DOI] 10.1016/j.bbagrm.2008.12.005. [PMID] 19167530.
2009
Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds.
Journal of the American Society of Nephrology : JASN. 20(11):2338-47 [DOI] 10.1681/ASN.2008111196. [PMID] 19729441.
2009
mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms.
American journal of physiology. Cell physiology. 297(6):C1434-44 [DOI] 10.1152/ajpcell.00248.2009. [PMID] 19794149.
2008
A conserved E2F6-binding element in murine meiosis-specific gene promoters.
Biology of reproduction. 79(5):921-30 [DOI] 10.1095/biolreprod.108.067645. [PMID] 18667754.
2008
The publishing game: reflections of an editorial team.
Laboratory investigation; a journal of technical methods and pathology. 88(12):1258-63 [DOI] 10.1038/labinvest.2008.113. [PMID] 19020521.
2007
A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT.
Journal of neuro-oncology. 84(2):185-8 [PMID] 17332944.
2007
A heterogeneous expression pattern for Nanog in embryonic stem cells
. 25:2534-2542
2007
A heterogeneous expression pattern for Nanog in embryonic stem cells.
Stem cells (Dayton, Ohio). 25(10):2534-42 [PMID] 17615266.
2007
Bypassing heterogeneity: the road to embryonic stem cell-derived cardiomyocyte specification.
Trends in cardiovascular medicine. 17(3):96-101 [PMID] 17418371.
2007
Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling.
Molecular and cellular biology. 27(12):4347-54 [PMID] 17403895.
2007
Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells.
Circulation. 115(5):617-26 [PMID] 17261658.
2007
Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis.
The Journal of biological chemistry. 282(40):29658-66 [PMID] 17681941.
2007
Immunohistochemical analyses on serum proteins in nephrons of protein-overload mice by “in vivo cryotechnique”.
Histology and histopathology. 22(2):137-45 [DOI] 10.14670/HH-22.137. [PMID] 17149686.
2007
Recent development of in vivo cryotechnique to cryobiopsy for living animals.
Histology and histopathology. 22(11):1281-90 [DOI] 10.14670/HH-22.1281. [PMID] 17647200.
2007
Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies.
Molecular biology of the cell. 18(9):3375-87 [PMID] 17596515.
2006
Application of in vivo cryotechnique to the examination of cells and tissues in living animal organs.
Histology and histopathology. 21(3):265-72 [DOI] 10.14670/HH-21.265. [PMID] 16372248.
2006
CpG sites preferentially methylated by Dnmt3a in vivo.
The Journal of biological chemistry. 281(15):9901-8 [PMID] 16439359.
2006
Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension.
Laboratory investigation; a journal of technical methods and pathology. 86(1):62-71 [PMID] 16357868.
2006
Immunohistochemical study of serum albumin in normal and cadmium-treated mouse testis organs by “in vivo cryotechnique”.
Histology and histopathology. 21(1):35-40 [DOI] 10.14670/HH-21.35. [PMID] 16267785.
2006
Lentiviral vector-mediated gene transfer in embryonic stem cells.
Methods in molecular biology (Clifton, N.J.). 329:273-81 [PMID] 16845997.
2006
Self-assembled copper-capillary alginate gel scaffolds with oligochitosan support embryonic stem cell growth.
Journal of biomedical materials research. Part A. 79(2):440-50 [PMID] 16941595.
2006
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells.
Molecular and cellular biology. 26(20):7539-49 [PMID] 16908534.
2005
De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine.
Oncogene. 24(19):3091-9 [PMID] 15735669.
2005
DNA methylation is required for silencing of Ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells
. 23:1314-1323
2005
DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells.
Stem cells (Dayton, Ohio). 23(9):1314-23 [PMID] 16051982.
2005
Immunohistochemical analyses on albumin and immunoglobulin in acute hypertensive mouse kidneys by “in vivo cryotechnique”.
Histology and histopathology. 20(3):807-16 [DOI] 10.14670/HH-20.807. [PMID] 15944930.
2005
Terrestrial nitrogen and noble gases in lunar soils.
Nature. 436(7051):655-9 [PMID] 16079836.
2004
Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.
Journal of cell science. 117(Pt 23):5681-6 [PMID] 15494369.
2004
Cell fusion and reprogramming: resolving our transdifferences.
Trends in molecular medicine. 10(3):93-6 [PMID] 15106589.
2004
Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells.
Neurochemistry international. 45(7):1067-73 [PMID] 15337306.
2004
STAT3 induces anti-hepatitis C viral activity in liver cells.
Biochemical and biophysical research communications. 324(2):518-28 [PMID] 15474458.
2004
Stem cell plasticity, beyond alchemy.
International journal of hematology. 79(1):15-21 [PMID] 14979473.
2003
Cell fusion and plasticity.
Cytotechnology. 41(2-3):103-9 [DOI] 10.1023/A:1024870605447. [PMID] 19002947.
2003
In vitro differentiation of embryonic stem cells into hepatocytes.
Methods in enzymology. 365:277-87 [PMID] 14696353.
2003
Induction of apoptosis by castration in epithelium of the mouse seminal vesicles.
Archives of andrology. 49(6):409-15 [PMID] 14555324.
2003
Signal transduction study using gene-targeted embryonic stem cells.
Methods in molecular biology (Clifton, N.J.). 218:35-46 [PMID] 12616710.
2002
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature. 416(6880):542-5 [PMID] 11932747.
2002
CD9 is associated with leukemia inhibitory factor-mediated maintenance of embryonic stem cells.
Molecular biology of the cell. 13(4):1274-81 [PMID] 11950938.
2002
Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes.
Hepatology (Baltimore, Md.). 36(1):22-9 [PMID] 12085345.
2002
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.
Proceedings of the National Academy of Sciences of the United States of America. 99(6):3866-71 [PMID] 11891332.
2001
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.
Circulation. 104(6):705-10 [PMID] 11489779.
2001
Clathrin-dependent and clathrin-independent endocytosis are differentially sensitive to insertion of poly (ethylene glycol)-derivatized cholesterol in the plasma membrane.
Traffic (Copenhagen, Denmark). 2(7):501-12 [PMID] 11422943.
2001
Hepatic maturation in differentiating embryonic stem cells in vitro.
FEBS letters. 497(1):15-9 [PMID] 11376655.
2001
IkappaB kinase alpha is essential for mature B cell development and function.
The Journal of experimental medicine. 193(4):417-26 [PMID] 11181694.
2001
Interleukin-18 up-regulates osteoprotegerin expression in stromal/osteoblastic cells.
Biochemical and biophysical research communications. 281(2):361-6 [PMID] 11181055.
2001
Malignant portal venous obstructions treated by stent placement: significant factors affecting patency.
Journal of vascular and interventional radiology : JVIR. 12(12):1407-15 [PMID] 11742015.
2001
Muscle repair after a transsection injury with development of a gap: an experimental study in rats.
Scandinavian journal of plastic and reconstructive surgery and hand surgery. 35(3):233-8 [PMID] 11680391.
2001
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD.
Proceedings of the National Academy of Sciences of the United States of America. 98(17):9666-70 [PMID] 11493700.
2001
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
The EMBO journal. 20(16):4370-9 [PMID] 11500364.
2001
Role of phasic dynamism of P38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart
. 2:175-180
2001
Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart.
Circulation research. 88(2):175-80 [PMID] 11157669.
2001
Stem cells: a journey into a new frontier.
Journal of the American Society of Nephrology : JASN. 12(8):1773-1780 [DOI] 10.1681/ASN.V1281773. [PMID] 11461953.
2000
CD40 and adenosine A2 receptor agonist-cyclic adenosine monophosphate rescue B-cell antigen receptor-induced apoptosis through independent pathways and converge to prevent caspase activation.
The Journal of allergy and clinical immunology. 105(3):522-31 [PMID] 10719303.
2000
CD40 and adenosine A2 receptor agonist/cyclic AMP rescue B cell antigen receptor induced apoptosis via independent pathways.
. 105:522-531
2000
Chronic treatment with FK506 increases p70 S6 kinase activity associated with reduced nitric oxide synthase activity in rabbit hearts.
Cardiovascular drugs and therapy. 14(3):329-36 [PMID] 10935155.
2000
Content and sulfation pattern of keratan sulfate in hip osteoarthritis using high performance liquid chromatography.
The Journal of rheumatology. 27(7):1721-4 [PMID] 10914858.
2000
Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes.
Cellular immunology. 201(2):109-23 [PMID] 10831320.
2000
Expression of keratan sulfate at the arthroplasty surface after cup arthroplasty.
Archives of orthopaedic and trauma surgery. 120(7-8):473-5 [PMID] 10968545.
2000
Hyaluronan in synovial fluid of patients with loose total hip prosthesis. Comparison with hyaluronan in patients with hip osteoarthritis and idiopathic osteonecrosis of femoral head.
Archives of orthopaedic and trauma surgery. 120(9):521-4 [PMID] 11011673.
2000
Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats.
Cardiovascular drugs and therapy. 14(5):533-42 [PMID] 11101202.
2000
Interleukin-13 and tumour necrosis factor-alpha synergistically induce eotaxin production in human nasal fibroblasts.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 30(3):348-55 [PMID] 10691892.
2000
Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish.
Genes to cells : devoted to molecular & cellular mechanisms. 5(9):725-38 [PMID] 10971654.
2000
Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy.
Tissue antigens. 56(5):446-8 [PMID] 11144293.
2000
The importance of reducing small fractures of the coronoid process in the treatment of unstable elbow dislocation.
Journal of shoulder and elbow surgery. 9(4):344-6 [PMID] 10979534.
2000
The role of oval cells in rat hepatocyte transplantation.
Transplantation. 70(3):441-6 [PMID] 10949185.
1999
Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation.
The Journal of biological chemistry. 274(2):1092-9 [PMID] 9873056.
1999
Autonomic nerve tumour with skeinoid fibres: ultrastructure of skeinoid fibres examined by quick-freezing and deep-etching method.
Virchows Archiv : an international journal of pathology. 434(3):267-76 [PMID] 10190310.
1999
Characterization of S6K2, a novel kinase homologous to S6K1.
Oncogene. 18(36):5108-14 [PMID] 10490847.
1999
Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy.
Journal of the neurological sciences. 162(1):38-50 [PMID] 10064167.
1999
Differential activation and regulation of mitogen-activated protein kinases through the antigen receptor and CD40 in human B cells.
European journal of immunology. 29(9):2999-3008 [PMID] 10508274.
1999
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
Immunity. 10(1):39-49 [PMID] 10023769.
1999
L-Asparaginase inhibits the rapamycin-targeted signaling pathway.
Biochemical and biophysical research communications. 260(2):534-9 [PMID] 10403802.
1999
Limb and skin abnormalities in mice lacking IKKalpha.
Science (New York, N.Y.). 284(5412):313-6 [PMID] 10195895.
1999
MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America. 96(26):15127-32 [PMID] 10611349.
1999
Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells.
Journal of immunology (Baltimore, Md. : 1950). 162(4):2087-94 [PMID] 9973482.
1999
Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.
Melanoma research. 9(3):279-91 [PMID] 10465584.
1999
p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis.
Molecular and cellular biology. 19(4):2485-94 [PMID] 10082514.
1999
Role of c-kit receptor tyrosine kinase in development of oval cells in the rat 2-acetylaminofluorene/partial hepatectomy model.
Hepatology (Baltimore, Md.). 29(3):670-6 [PMID] 10051467.
1998
Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis.
The Journal of biological chemistry. 273(24):15077-84 [PMID] 9614117.
1998
Expression of histamine receptors in nasal epithelial cells and endothelial cells–the effects of sex hormones.
International archives of allergy and immunology. 115(3):220-7 [PMID] 9531164.
1998
Involvement of Fas in the apoptosis of mouse germ cells induced by experimental cryptorchidism.
Urological research. 26(1):17-21 [PMID] 9537691.
1998
Requirement for dual signals by anti-CD40 and IL-4 for the induction of nuclear factor-kappa B, IL-6, and IgE in human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 161(4):1738-42 [PMID] 9712038.
1998
Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells.
Journal of immunology (Baltimore, Md. : 1950). 161(7):3624-30 [PMID] 9759885.
1998
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
Genes to cells : devoted to molecular & cellular mechanisms. 3(12):801-10 [PMID] 10096021.
1998
Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America. 95(9):5033-8 [PMID] 9560223.
1998
Three-dimensional ultrastructure of apoptotic nuclei in rat prostatic epithelial cells revealed by a quick-freezing and deep-etching method.
The Prostate. 35(3):193-202 [PMID] 9582088.
1997
Absence of mast cell involvement in leukocyte adhesion and emigration induced by inhibition of nitric oxide synthase.
Laboratory investigation; a journal of technical methods and pathology. 77(6):575-80 [PMID] 9426394.
1997
Mast cell tumor necrosis factor alpha production is regulated by MEK kinases.
Proceedings of the National Academy of Sciences of the United States of America. 94(12):6358-63 [PMID] 9177222.
1997
Overexpression of wild type p70 S6 kinase interferes with cytokinesis.
Oncogene. 15(4):443-52 [PMID] 9242381.
1997
Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells.
Biochemical and biophysical research communications. 230(2):386-91 [PMID] 9016789.
1997
The effects of eotaxin on the surface adhesion molecules of endothelial cells and on eosinophil adhesion to microvascular endothelial cells.
Biochemical and biophysical research communications. 241(1):136-41 [PMID] 9405247.
1997
Vesnarinone inhibits adenosine uptake in endothelial cells, smooth muscle cells and myocytes, and mediates cytoprotection.
Journal of molecular and cellular cardiology. 29(12):3413-7 [PMID] 9441846.
1996
Activation of p42erk2 MAPK and p90rsk by IL-2 occurs independently of protein kinase C.
Clinical immunology and immunopathology. 80(2):116-22 [PMID] 8764555.
1996
Aggregation of the FcepsilonRI on mast cells stimulates c-Jun amino-terminal kinase activity. A response inhibited by wortmannin.
The Journal of biological chemistry. 271(22):12762-6 [PMID] 8662803.
1996
Dissociation of EBV genome replication and host cell proliferation in anti-IgG-stimulated Akata cells.
Clinical immunology and immunopathology. 81(2):168-74 [PMID] 8906748.
1996
Genetic and epigenetic resistance of SL/Ni mice to lymphomas.
Japanese journal of cancer research : Gann. 87(3):258-62 [PMID] 8613427.
1996
p70 S6 kinase sensitivity to rapamycin is eliminated by amino acid substitution of Thr229.
Journal of immunology (Baltimore, Md. : 1950). 157(2):656-60 [PMID] 8752914.
1996
Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase.
Biochemical and biophysical research communications. 227(2):507-12 [PMID] 8878544.
1995
Control of cell cycle entry and progression in mitogen-stimulated human B lymphocytes.
Journal of cellular physiology. 162(2):246-55 [PMID] 7529768.
1995
Danazol concentrations in ovary, uterus, and serum and their effect on the hypothalamic-pituitary-ovarian axis during vaginal administration of a danazol suppository.
Fertility and sterility. 63(6):1184-9 [PMID] 7750586.
1995
Differential regulation of the synthesis and activity of the major cyclin-dependent kinases, p34cdc2, p33cdk2, and p34cdk4, during cell cycle entry and progression in normal human T lymphocytes.
Journal of cellular physiology. 165(2):406-16 [PMID] 7593219.
1995
Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase.
Blood. 86(6):2268-80 [PMID] 7662974.
1995
IL-4 upregulates Fc epsilon RI alpha-chain messenger RNA in eosinophils.
The Journal of allergy and clinical immunology. 96(6 Pt 2):1161-9 [PMID] 8543773.
1995
Nerve growth factor induces activation of MAP-kinase and p90rsk in human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 154(10):4965-72 [PMID] 7730607.
1995
Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes.
Biochemical and biophysical research communications. 209(3):1111-8 [PMID] 7733966.
1995
Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 155(7):3418-26 [PMID] 7561036.
1995
Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells.
The Journal of biological chemistry. 270(51):30823-8 [PMID] 8530526.
1995
Symmetry of the activation of cyclin-dependent kinases in mitogen and growth factor-stimulated T lymphocytes.
Annals of the New York Academy of Sciences. 766:134-48 [PMID] 7486650.
1995
Vesnarinone inhibits nucleoside and nucleobase transport.
Life sciences. 57(6):PL75-81 [PMID] 7623619.
1994
Activation of MAP2-kinase in B lymphocytes by calcium ionophores.
Journal of immunology (Baltimore, Md. : 1950). 153(11):4890-8 [PMID] 7963552.
1994
Differential activation of p21ras in CD45RA+ and CD45RO+ human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 152(6):2830-6 [PMID] 8144884.
1994
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.
Proceedings of the National Academy of Sciences of the United States of America. 91(24):11477-81 [PMID] 7972087.
1994
Regulation of B-cell immune responses: predominant role of interleukin-4 in triggering cell proliferation and Ig production in competent B cells.
Clinical immunology and immunopathology. 72(1):141-9 [PMID] 8020187.
1994
Release from G0/G1 arrest induced by dimethyl sulfoxide in human lymphoid cells: regulation of synthesis and activation of the p33cdk2 and p34cdc2 kinases.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 5(10):1051-9 [PMID] 7848906.
1993
Acute infectious mononucleosis stimulates the selective expression/expansion of V beta 6.1-3 and V beta 7 T cells.
Blood. 81(6):1521-6 [PMID] 8453099.
1993
Characterization of the progression signal for human T-cell proliferation provided by monoclonal antibodies to the CD3-TCR complex.
Clinical immunology and immunopathology. 67(3 Pt 1):232-9 [PMID] 8500271.
1993
Definition of the roles for iron and essential fatty acids in cell cycle progression of normal human T lymphocytes.
Experimental cell research. 204(2):260-7 [PMID] 8440323.
1993
Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase.
The Journal of biological chemistry. 268(16):12062-8 [PMID] 8389370.
1993
Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle.
Cancer research. 53(17):3968-75 [PMID] 8358725.
1993
Platelet-activating factor triggers the phosphorylation and activation of MAP-2 kinase and S6 peptide kinase activity in human B cell lines.
Journal of immunology (Baltimore, Md. : 1950). 151(4):1802-10 [PMID] 7688385.
1993
Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle.
Journal of cellular physiology. 154(1):7-15 [PMID] 8419408.
1993
Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.
The EMBO journal. 12(11):4181-9 [PMID] 8223433.
1992
IL-4 and IL-2 promote human T-cell proliferation through symmetrical but independent pathways.
Clinical immunology and immunopathology. 64(3):210-7 [PMID] 1643754.
1992
Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells.
Biochemical and biophysical research communications. 186(3):1315-21 [PMID] 1380801.
1992
Regulation of synthesis of p34cdc2 and its homologues and their relationship to p110Rb phosphorylation during cell cycle progression of normal human T cells.
Journal of immunology (Baltimore, Md. : 1950). 148(6):1804-11 [PMID] 1541821.
1992
Signal transduction by interleukin 2 in human T cells: activation of tyrosine and ribosomal S6 kinases and cell-cycle regulatory genes.
Journal of cellular physiology. 151(2):367-77 [PMID] 1315323.
1992
Transcription of IL-2 and IL-4 genes is not inhibited by cyclosporin A in competent T cells.
The Journal of biological chemistry. 267(29):21207-10 [PMID] 1400432.
1991
A case of pelvic lipomatosis presenting with edema of the lower extremities.
Japanese journal of medicine. 30(6):559-63 [PMID] 1798216.
1991
Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells.
Journal of immunology (Baltimore, Md. : 1950). 147(2):698-704 [PMID] 1906503.
1991
N-ras gene mutations in childhood acute non-lymphoblastic leukemia.
Leukemia research. 15(10):935-41 [PMID] 1921453.
1991
Tuberculous bronchial stenosis: treatment with balloon bronchoplasty.
AJR. American journal of roentgenology. 157(6):1187-8 [PMID] 1950862.
1989
Androgen dependency of a tumor produced by a cell line derived from androgen-responsive Shionogi carcinoma 115.
Cancer research. 49(3):693-8 [PMID] 2910490.
1989
Clinical value of deconvolution analysis in radionuclide renal study.
Radiation medicine. 7(5):236-42 [PMID] 2697894.
1988
[Simplified technique of transarterial placement of a long-term retaining infusion catheter–reverse application of guidewire as a guide for arterial cut down approach].
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 48(6):773-5 [PMID] 3217254.
1987
[Clinical usefulness of CT and MRI in the diagnosis of popliteal artery occlusive diseases].
Rinsho hoshasen. Clinical radiography. 32(13):1625-8 [PMID] 3448296.
1985
[Regional cerebral blood flow in cerebrovascular disease studied using N-isopropyl-p-(123I) iodoamphetamine].
Radioisotopes. 34(7):364-70 [PMID] 3877955.
1983
The interaction of cortisol and prostaglandins on the phenotypic expression of the alpha-lactalbumin gene in the mouse mammary gland in culture.
Biochemical and biophysical research communications. 111(3):1059-65 [PMID] 6340674.
1982
Selective stimulation of alpha-lactalbumin synthesis and its mRNA accumulation by thyroid hormone in the differentiation of the mouse mammary gland in vitro.
FEBS letters. 149(1):101-4 [PMID] 7152028.

Grants

Sep 2019 – Aug 2022
Genetic Modification to Harness the Regenerative Power of the African Spiny Mouse
Role: Project Manager
Funding: NATL INST OF HLTH OD
Aug 2019 – Jul 2021
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Aug 2018 – Dec 2022
Model Systems of Mammalian Regeneration
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2018 – Jan 2021
Mechanisms and Treatment of Cardiac and Skeletal Muscular Dysfunction in Barth Syndrome
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Apr 2018 – Feb 2019
Role of Macrophages in HHT Pathogenesis and Therapy
Role: Principal Investigator
Funding: ST JOSEPHS HOSPITAL AND MEDICAL CNTR via NATL INST OF HLTH NHLBI
Sep 2017 – Nov 2019
Pathogenesis of vascular malformations in hereditary hemorrhagic telangiectasia: from disease mechanism to new therapies
Role: Principal Investigator
Funding: ST JOSEPHS HOSPITAL AND MEDICAL CNTR via US ARMY MED RES ACQUISITION
Apr 2017 – Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jan 2017 – Jun 2018
Mechanisms of Cardiac and Skeletal Muscle Dysfunction in Barth Syndrome
Role: Co-Investigator
Funding: AMER HEART ASSOCIATION
Sep 2016 – Aug 2019
Membrane estrogen receptor 1 mediation of epigenetic effects of estrogen
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2016 – Sep 2020
A stem cell tactic to promote personalized medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jul 2016 – Jun 2018
A Stem Cell Tactic to Promote Personalized Medicine in Hypertension
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Nov 2015 – Jan 2020
Miscellaneous Donors
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Apr 2015 – Jun 2021
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Sep 2014 – Jun 2019
Genetic Regulation of Human Beta Cell Destruction
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Sep 2011 – Aug 2016
Developmental programming during preimplantation development
Role: Project Manager
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Aug 2011 – Aug 2016
ANT2 and Cancer
Role: Principal Investigator
Funding: OTSUKA MARYLAND MEDICINAL LAB
Aug 2010 – Jul 2017
Pharmacogenomic Evaluation of Antihypertensive Responses.
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Education

MD
1981 · Osaka University Graduate School of Medicine

Contact Details

Phones:
Business:
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