Specimen: Serum (preferred) or plasma
Volume: 1 mL
Container: Gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube
Collection: Separate serum or plasma from cells.
Storage Instructions: Maintain specimen at room temperature.
Detection of hereditary decreases in the production of α1-antitrypsin (α1AT). Decreased or nearly absent levels of α1AT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with CAH. Cirrhosis in a child should raise consideration of α1AT deficiency or Wilson's disease. Diagnosis of inflammatory states, if elevated (eg, rheumatoid arthritis, bacterial infection, vasculitis, neoplasia).