Anti-Beta-2 Glycoprotein 1 Antibodies, IgG & IgM

Additional Information:

UFHPL Epic order code: LAB1179

CPT Code(s):

86146 x 2

Specimen Requirements:

Type: Plasma (preferred) or Serum
Container/Tube: Sodium Citrate (Light Blue Top) or SST
Sample Volume: 1 mL
Minimum Volume: 0.1 mL (Repeat testing is not possible with this specimen volume.)
Storage: Centrifuge, separate and transfer the plasma or serum to a plastic vial. Ship specimens with a frozen cold pack for overnight delivery.
Stability (collection to time of analysis/testing):

  • Refrigerated: 48 hours
  • Frozen: 1 year


This assay is used in the diagnosis of antiphospholipid

Vascular Thrombosis: One or more clinical episodes of arterial, venous or small-vessel thrombosis in any
tissue or organ.

Pregnancy Morbidity:

  • One or more unexplained deaths of a morphologically normal fetus at or beyond the tenth week of gestation, with normal fetal morphology documented by ultrasound.
  • One or more premature births of a morphologically normal neonate before the 34th week of gestation because of (a) eclampsia or severe preeclampsia divined according to standard definitions or (b) recognized features of placental insufficiency.
  • Three or more unexplained consecutive spontaneous abortions before the tenth week of gestation, with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes excluded.
Laboratory criteria for the antiphospholipid syndrome include:

  • Anti-β2 glycoprotein-I antibody of IgG and/or IgM isotype in serum or plasma (in titer > the 99th percentile)


Enzyme- linked immunosorbent assay (ELISA)


1-7 Business Days

Reference Values:


  • β2 GPI IgG ≤ 20 SGU U/mL
  • β2 GPI IgM ≤ 20 SMU U/mL

  • β2 GPI IgG > 20 SGU U/mL
  • β2 GPI IgM > 20 SMU U/mL