Celiac Disease Profile

Additional Information:

UFHPL Epic order code: LAB4803

Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as one percent of the population in the United States. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, et cetera. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.


  • Baigi F, Pezzimenti D, Campanella J, et al. Endomysial and tissue transglutaminase antibodies in coeliac sera: A comparison not influenced by previous serological testing. Scand J Gastroenterol. 2001 Sep; 36(9):955-958. PubMed 11521986
  • B├╝rgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug; 66(8):941-947. PubMed 1819255
  • Calabuig M, Torregosa R, Polo P, et al. Serological markers and celiac disease: A new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May; 10(4):435-442. PubMed 2193137
  • Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2; 362(9381):383-391. PubMed 12907013
  • National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
  • Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1; 57(5):1023-1034, 1039-1041. PubMed 9518950

CPT Code(s):

82784, 83516, 86255

Specimen Requirements:

Important: Specimens should be free of bacterial contamination, hemolysis and lipemia.

Type: Serum

Container/Tube: Red-top tube or gel-barrier tube

Sample Volume: 3 mL

Minimum Volume: 1 mL

Storage: Store specimens at room temperature after collection.

Stability (collection to time of analysis/testing):

  • Ambient: 14 days
  • Refrigerated: 14 days
  • Frozen: 14 days
  • Freeze/Thaw cycles: Stable (x3)
Rejection Criteria:

  • Gross bacterial contamination
  • Lipemia
  • Hemolysis


This test is used to diagnose gluten-sensitive enteropathies.

It includes:


Enzyme immunoassay (EIA); indirect immunofluorescence