Chromosome Study: Chorionic Villi

CPT Code(s):

  • 88235
  • 88267
  • 88285
  • 88280
  • 88291

Specimen Requirements:

Chorionic Villi: Collect 10 - 30 mg of chorionic villi, utilizing aspiration medium, containing sodium heparin. After assessment of the appropriate amount and quality of villi, transfer it to a sterile centrifuge tube with a transportation medium.

Do not freeze or fix samples in any manner contrary to the maintenance of cell viability. Maintain sample sterility; keep all specimens at room temperature; and deliver samples to the laboratory within 24 - 48 hours. Ship specimens at room temperature for overnight delivery.

  • Unacceptable Conditions:
    • Frozen specimens
    • Specimens greater than 48 hours old*
  • Stability (collection to initiation of testing):
    • Ambient: 24 - 48 hours old*
    • Frozen: Unacceptable

* Cell viability of specimens requiring cell culture may be compromised in specimens more than 48 hours old upon receipt. Refrigeration at 2° - 8° C may assist when a delay in delivery is unpreventable. Do not freeze or place specimens directly on ice.


This test is used to detect fetal chromosome abnormalities at 11 - 15 weeks of gestation.


Classic cytogenetic G-band analysis (karyotyping); requires cell culture


10 - 14 days

Reference Values:

By report; interpretive


Monday - Saturday