Additional Information:
UFHPL Epic order code: LAB5851
For each required FISH analysis, select the entire panel or customize your own panel.
If the probe is unspecified, call UF Health Pathology Laboratories at 888.375.LABS (5227) for availability.
*Please note: If ordering both a chromosome analysis/FISH study AND a microarray analysis, please draw two separate tubes of blood. Chromosomes/FISH studies require as close to 2.0ml+ as possible, collected in a dark green sodium heparin tube. Microarrays require the same volume (~2.0ml+) and the preferred tube is a lavender EDTA, but a dark green sodium heparin is also acceptable. Further details for UF PathLab’s cytogenetics requirements are available here and LabCorp microarray requirements are available here.
FISH Panels: 7-14 days
Myelodysplastic syndrome (MDS)
EGR1 (del 5q/mono 5)
D7S522 (del 7q/mono 7)
D8Z2
D20S108 (del 20q)
Acute myeloid leukemia (AML)
RUNX1T1/RUNX1 [t(8;21)]
BCR/ABL1 [t(9;22)]
KMT2A
CBFB::MYH11
TP53
AML COG
RUNX1T1/RUNX1 [t(8;21)]
KMT2A
CBFB::MYH11
Acute lymphoid leukemia (ALL) COG standard risk
BCR/ABL1 [t(9;22)]
KMT2A
ETV6/RUNX1 [t(12;21)]
CEP 4/CEP 10
ALL COG high risk
Std risk PLUS:
ABL2
PDGFRB
ABL1
ALL pediatric non-COG
TCF3/PBX1 [t(1;19)]
CKDN2A (del 9p)
BCR/ABL1 [t(9;22)]
KMT2A
ETV6/RUNX1 [t(12;21)]
CEP 4/CEP 10
ALL adult
TCF3/PBX1 [t(1;19)]
BCR/ABL1 [t(9;22)]
KMT2A
ETV6/RUNX1 [t(12;21)]
Plasma cell neoplasm (PCN) or multiple myeloma (MM)
CKS1B (1q)
Chromosome 5-9-15 Aueuploidy
D13S319 (del 13q/mono 13)
IGH
TP53
Chronic lymphocytic leukemia (CLL)
ATM (del 11q)
D12Z3
D13S319 (del 13q/mono 13)
TP53
Myeloproliferative neoplasm (MPN) w/ eosinophilia
BCR/ABL1 [t(9;22)]
ETV6
PDGFRb
NHL
BCL6
MYC
IGH/CCND1 [t(11;14)]
BCL2
T-ALL or mixed lineage leukemia
BCR/ABL1 [t(9;22)]
KMT2A
FISH Study: APL STAT FISH for t(15;17) PML::RARA: 24-28 hours
FISH Study: 22q11.2 Microdeletion Syndrome (DiGeorge/VCF): 7-21 days
FISH Study: SRY Sex Determination (Yp11.3): 7-21 days
FISH Study: X/Y Sex Chromosome Determination: 7-21 days
Methodology:
Fluorescence in-situ hybridization (FISH)