Group A Streptococcus Direct, DNA Probe

Additional Information:


  • Gen-Probe® Group a Streptococcus Direct Test package insert, Gen-Probe®, Inc., San Diego, California

CPT Code(s):


Specimen Requirements:

Type: Swab of posterior oropharynx, tonsil, or other inflamed area
Container/Tube: Copan Double Dacron dry swab in transport tube without medium (red cap)

Sample Volume: One or two swabs

Storage: Throat swabs are transported to the laboratory at room temperature for 48 hours after specimen collection. After receipt in the laboratory, specimens are stored at 2°C to 8°C and tested within 72 hours.
Rejection Criteria:

  • Throat swab that contains visible blood;
  • Improper labeling
  • Inappropriate specimen transport device
  • Specimen received after prolonged delay (more than 48 hours)
  • Source other than throat


This test uses nucleic acid hybridization for the qualitative detection of group A streptococcal RNA as an aid in the diagnosis of group A streptococcal pharyngitis from throat swabs.


Blood and potentially other chemiluminescent substances may interfere with this test. A negative test does not exclude the possibility that the numbers of group A streptococcal cells may be below the level of detection of the assay. Some strains of Streptococcus equi and rare strains of nonhemolytic streptococci which react with group G antisera may result in a false-positive reaction.


DNA probe