HER2/Neu by Fluorescence In-Situ Hybridization (FISH)

CPT Code(s):

88377 x 2

Specimen Requirements:

Tissue in formalin-fixed, paraffin-embedded tissue or at least 5 unstained slides.

Storage/Transport Temperature: Submit specimens according to Biological Substance, Category B, shipping guidelines.

Unacceptable Conditions:
  • Frozen specimens
Stability (collection to initiation of testing):
  • Ambient:
    • Fixed Slides: Indefinitely


This test is used as a qualitative predictor of response to certain breast cancer therapies; it detects the HER2/Neu protein in breast cancer patients, which effects patient survival time and relapse.




7 days