Additional Information:
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CPT Code(s):
87621
Collection Procedure:
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Specimen Requirements:
- Cervical Brushes: Specimens must be collected prior to the application of acetic acid or iodine if colposcopic examination is being performed. The samples should be collected by using a Digene cervical brush and stored in Digene STM solution.
- Cervical Biopsies: Specimens must be freshly collected, 2 – 5 mm in cross section. The biopsy specimen must be placed immediately into 1.0 mL of STM and stored frozen.
- Specimens in ThinPrep® Cytyc PreservCyt® Solution: There must be at least 4 mL of PreservCyt® solution remaining for the HPV DNA test.
- Specimen in SurePath™ (AutoCyte) Solution: There are must be 2 mL of SurePath™ solution remaining for the HPV DNA test.
Remarks: Vaginal specimens are not preferred.
Handling: Cervical-brush specimens may be shipped without refrigeration to a testing laboratory; however, fresh specimens should be shipped in an insulated container using either an overnight or second-day delivery vendor.
Cervical biopsy specimens may be shipped at 2° – 30° C for overnight delivery to the testing laboratory.
- Frozen specimens
- Swabs or samples in any other transport media
- Ambient: SurePath™; 4 weeks at 15° – 30° C.
- Ambient: Thin Prep® or PreservCyt®; 3 weeks at 15° – 30° C.
Use:
The HPV DNA, high-risk test is used in conjunction with liquid-based cytology screenings to detect cervical cancer.
Methodology:
Nucleic acid probe
Reported:
4 days
Reference Values:
Negative (interpretative report provided)
Interpretation Data:
HPV DNA was detected by using the FDA-approved testing kit, Hybrid Capture 2. The test detects HPV high-risk genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68.
| Diagnosis | Interpretation Text |
| Detected | High-risk HPV DNA was detected in this patient sample. |
| Not Detected | High-risk HPV DNA was not detected in this patient sample. |
| QNS | Due to inadequate specimens, resubmission of samples is suggested. |