Intraepidermal Nerve Density Analysis

Additional Information:

UFHPL Test #: 93230

CPT Code(s):

88342 x2 PGP 9.5; 88356 x2 Morphometric Analysis, Nerve. Additional billing may apply if special studies are indicated.

Collection Procedure:

Specimen Requirements:

To obtain an intraepidermal nerve density kit (#0100) and detailed collection instructions, contact UF Health Pathology Laboratories’ Client Services Department at 888.375.LABS (5227).

Two 3 mm skin-punch biopsies from leg and thigh.

Storage/Transport Temperature: Ship biopsies using a nerve fiber fixative collection kit at 2 – 8° C. Use Zamboni’s Formula and cryoprotectant for transportation of specimens. Use phosphate buffer to rinse specimens before storage in cryoprotectant.
Unacceptable Conditions:
  • Specimens in inappropriate fixative
  • Ambient
  • Frozen specimens
Stability (collection to initiation of testing):
  • Refrigerated: 2 weeks


This test is used to determine the amount of neuropathy damage present and as a predicative test of impending neuropathy


Immunohistochemistry/Microscopic exam


1 – 5 days

Reference Values:

Interpretation Data: