Thyroperoxidase Autoantibodies (TPOA)

Additional Information:

EPIC Test Name: THYROID PEROXIDASE ANTIBODY

CPT Code(s):

86376

Specimen Requirements:

Type: Serum
Container/Tube: SST
Sample Volume: 1 mL
Minimum Volume: 0.1 mL (Repeat testing is not possible with this specimen volume.)
Storage: Centrifuge, separate and transfer the serum to a plastic vial. Ship specimens with a frozen cold pack for overnight delivery.
Stability (collection to time of analysis/testing):

  • Refrigerated: 7 days
  • Frozen: Indefinitely

Use:

  • Diagnosis of Autoimmune Thyroid Disease: The detection of either thyroperoxidase autoantibodies (TPOA) or thyroglobulin autoantibodies (TGA) in the presence of biochemically defined hypothyroidism or euthyroid goiter identifies an autoimmune etiology as the cause of the subject’s thyroid disease.
  • Prediction of Autoimmune Thyroid Disease: The detection of TPOA and/or TGA in an asymptomatic individual indicates an increased risk for the subsequent development autoimmune thyroid disease that can produce goiter and/or either hypothyroidism (Hashimoto's thyroiditis or atrophic thyroiditis) or hyperthyroidism (Graves’ disease).

Methodology:

Radioimmunoassay

Reported:

1-10 business days

Reference Values:

<1.0 U/mL

Performed:

Weekly