Varicella Zoster Virus (VZV) Antibodies, IgG

Additional Information:

UFHPL Epic order code: LAB162

Although most cases of varicella or zoster are clinically unambiguous, serology may be occasionally useful in the differential diagnosis of other blistering illnesses or when infection shows an unusual complication, such as hepatitis. It may also be important to establish whether an individual is susceptible when clinical history is unclear, or when varicella immune globulin may be needed, as in the immunocompromised host or cancer patient on toxic chemotherapy. Zoster is more common with aging and may occur in the face of significant antibody titers, demonstrating that cell-mediated immunity is also significant.

CPT Code(s):


Specimen Requirements:

Type: Serum

Container/Tube: Red-top tube, gel-barrier tube

Sample Volume: 0.5 mL

Minimum Volume: 0.2 mL

Storage: Refrigerate specimens immediately after collection.

Stability (collection to time of analysis/testing):

  • Ambient: 2 days
  • Refrigerated: 2 days
  • Frozen: > 2 days
Rejection Criteria:

  • Hemolysis
  • Lipemia
  • Gross bacterial contamination


This test is used to diagnose VZV infection and; determine adult susceptibility to infection.


Chemiluminescent immunoassay (CLIA)

Reference Values:

Reference Intervals

  • Negative: < 135 index
  • Equivocal: 135 – 165 index
  • Positive: > 165 index