Zap-70 (cD-38) (cLL)

CPT Code(s):

  • 88184
  • 88185
  • 88186
  • 88187
  • 88188
  • 88189

Specimen Requirements:

Peripheral blood only

The Zap-70 assay for chronic lymphocytic leukemia/small lymphocytic lymphoma requires fresh peripheral blood specimens (less than 24 hours old after collection) for optimal results.

Collect 5 mL in an EDTA (purple-top) tube received within 24 hours of collection; performed on peripheral blood only.

For more information, contact the UF Health Pathology Laboratories Client Services Department at 888.375.LABS (5227).

Storage/Transport Temperature: Ship at 20° – 25° C. Submit specimens according to Biological Substance, Category B, shipping guidelines.

Unacceptable Conditions:
  • Bone marrow
  • Frozen specimens
  • Specimens greater than 24 hours old
Stability (collection to initiation of testing):
  • Ambient: Unacceptable
  • Refrigerated: 24 hours


Zap-70 and CD38 expression are prognostic markers in CLL.


Flow cytometry


5 days