Chromosome Study: Neoplastic Marrow/Blood

Additional Information:

UFHPL Epic order code: LAB5851

CPT Code(s):

  • 88237
  • 88262
  • 88291

Specimen Requirements:

Bone Marrow Aspirate: Obtain 1 – 2 cc of aspirate in a dark green-top sodium heparin tube and immediately rotate it thoroughly to ensure adequate mixing with the anticoagulant and prevent clotting.

Bone Marrow Core Biopsy: Deposit the sample in a sterile container containing RPMI or tissue culture medium with antibiotics, which has been brought to room temperature prior to collection.*

Peripheral Blood Specimens: These may be submitted in certain clinical conditions (e.g., circulating blasts) and/or circumstances where warranted.

Unacceptable Conditions:

  • Frozen specimens
  • Specimens greater than 48 hours old*
Stability (collection to initiation of testing):

  • Ambient: 24 – 48 hours old*
  • Frozen: Unacceptable

* Cell viability of specimens requiring cell culture may be compromised in specimens greater than 48 hours old upon receipt. Refrigeration at 2° – 8° C may assist when a delay in delivery is unpreventable. Do not freeze or place specimens directly on ice.

No formalin-, alcohol- or paraffin-preserved specimens. Do not freeze or fix samples in any manner contrary to the maintenance of cell viability. Maintain sample sterility; keep all specimens at room temperature; and deliver samples to the laboratory within 24 – 48 hours. Ship specimens at room temperature for overnight delivery.


This test is used to identify clonal chromosome changes by conventional karyotyping methods for the diagnosis and classification of various hematological disorders.


Classic cytogenetic G-band analysis (karyotyping); requires cell culture


7 – 21 days

Reference Values:

By report; interpretive