About Molecular Pathology
Molecular Pathology focuses on diagnosing and characterizing genetic mutations that drive various diseases, including cancers. By analyzing genetic changes, clinicians can tailor treatments to target specific mutations, optimizing care for each patient. UFHPL’s Molecular Pathology Laboratory offers comprehensive diagnostic services for a variety of conditions.
Molecular Pathology Services
Our laboratory provides the following diagnostic capabilities:
- Hematolymphoid Malignancies and Solid Tumors: Our diagnostic assays include targeted mutation profile analysis to aid in the diagnosis and management of leukemias, lymphomas and solid tumors.
- Pharmocogenomic Profiling: We provide testing for a range of pharmacogenomic markers related to commonly prescribed medications, including those used in oncology, cardiology, psychiatry, and pain management.
- Infectious Disease Testing: We offer nucleic acid analysis for a variety of specimen types targeting viral, bacterial and fungal pathogens including those associated with respiratory or urogenital infections.
Oncology
Our in-house testing provides fast, accurate results, with personalized interpretations by our expert pathologists.
The Gatorseq NGS Panel targets key genetic variants in over 718 genes relevant to cancer in blood, bone marrow or solid tumor specimens. This includes mutations with established roles in guiding therapeutic decisions or those linked to patient prognosis.
The Gatorseq Fusions assay can identify known and novel gene fusions in solid tumor specimens relevant in a variety of cancers.
B-cell and T-Cell Clonality Analysis for B-cell and T-cell gene rearrangements in blood, bone marrow or solid tumor specimens is useful in diagnosing hematopoietic disorders such as leukemias and lymphomas and facilitates better tracking and differentiation of clonal variations.
UFHPL’s FLT3 Analysis detects internal tandem duplication mutations in blood or bone marrow specimens associated with prognostic outcomes in patients with acute myelogenous leukemia (AML).
Pharmacogenomics
Pharmacogenomics explores how an individual’s genetic makeup influences their response to medications. UFHPL’s Pharmacogenomics testing helps clinicians personalize treatment plans by identifying genetic variations that affect drug metabolism, efficacy, and potential side effects. This approach ensures that patients receive the right drug at the optimal dose, minimizing adverse reactions and enhancing treatment outcomes.
Available panels:
GatorPGX Panel (CYP2C19, CYP2C9, CYP2D6, CYP3A5, SLCO1B1, CYP2C Cluster, CYP4F2, VKORC1)
PGX Warfarin Panel (CYP2C9/CYP4F2/VKORC1)
PGX Antidepressant Panel (CYP2C19/CYP2D6)
PGX TPMT/NUDT15 Panel
Available as single gene orders:
APOL1, CYP2C19, CYP2D6, DPYD, NAT2, TPMT, YEATS
Additional Molecular Pathology Services
Our laboratory offers a wide array of molecular tests, including those for coagulation disorders, infectious disease testing and Red Blood Cell Phenotyping. Each test is designed to provide clinicians with the detailed molecular information needed to inform treatment strategies.
Full UFHPL Molecular Pathology Test Menu