Immunoglobulin A, Quantitative

Additional Information:

UFHPL Epic order code: LAB73

Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially in multiple myeloma and Mediterranean lymphoma. involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG2 and IgG4. IgA may be decreased in patients with chronic sinopulmonary disease (in ataxia-telangiectasia or congenitally). Patients with congenital IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA and anaphylaxis if transfused. IgA levels may rise with exercise and fall during pregnancy.

CPT Code(s):


Specimen Requirements:

Type: Serum

Container/Tube: Red-top tube or gel-barrier tube

Sample Volume:

  • Adult: 1 mL
  • Pediatric: 0.4 mL

Storage: Store specimens at room temperature.

Stability (collection to time of analysis/testing):

  • Ambient: 14 days
  • Refrigerated: 14 days
  • Frozen: 14 days
  • Freeze/Thaw cycles: Stable (x3)
Causes for Rejection:

  • Excessive lipemia
Note: The patient’s age must be submitted with the test request.


This test evaluates humoral immunity and monitors therapy in IgA myeloma.



Reference Values:

IgA Quantitation Reference Intervals


Range (mg/dL)

0 – 11 months

11 − 58

1 – 2 years

20 − 101

3 – 6 years

44 − 189

7 – 12 years

62 − 236

13 – 17 years

77 − 278

>18 years

91 − 414