Additional Information:
UFHPL Epic order code: LAB73
Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially in multiple myeloma and Mediterranean lymphoma. involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG2 and IgG4. IgA may be decreased in patients with chronic sinopulmonary disease (in ataxia-telangiectasia or congenitally). Patients with congenital IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA and anaphylaxis if transfused. IgA levels may rise with exercise and fall during pregnancy.
CPT Code(s):
82784
Specimen Requirements:
Type: Serum
Container/Tube: Red-top tube or gel-barrier tube
Sample Volume:
- Adult: 1 mL
- Pediatric: 0.4 mL
Storage: Store specimens at room temperature.
Stability (collection to time of analysis/testing):
- Ambient: 14 days
- Refrigerated: 14 days
- Frozen: 14 days
- Freeze/Thaw cycles: Stable (x3)
Causes for Rejection:
- Excessive lipemia
Note: The patient’s age must be submitted with the test request.
Use:
This test evaluates humoral immunity and monitors therapy in IgA myeloma.
Methodology:
Immunoturbidimetric
Reference Values:
IgA Quantitation Reference Intervals
| Age | Range (mg/dL) |
|---|---|
| 0 – 11 months | 11 − 58 |
| 1 – 2 years | 20 − 101 |
| 3 – 6 years | 44 − 189 |
| 7 – 12 years | 62 − 236 |
| 13 – 17 years | 77 − 278 |
| >18 years | 91 − 414 |
Reported:
3 – 5 days