Sjögren’s Antibodies (Anti-SS-A/Anti-SS-B)

SS-A(Ro) is found in 60 to 70 percent of patients with Sjögren’s syndrome and 30 to 40 percent of patients with SLE. SS-B(La) is found in 50 to 60 percent of Sjögren’s syndrome and 10 to 15 percent of SLE. SS-A cannot be demonstrated by immunofluorescence (it is soluble in the buffers used), but SS-B may be seen as a speckled antinuclear pattern. SS-A and SS-B are particularly useful in ANA-negative cases of SLE, being present in a majority of such cases. Patients who are ANA-positive and who have SS-A but not SS-B are very likely to have nephritis. Antibodies to SS-A are also associated with HLA loci DR3 and DR2 and with hereditary deficiency of C2. Anti-SS-A and anti-SS-B are found in virtually all children with neonatal lupus. Patients with SS-A may also have antibodies to cardiolipin, lupus anticoagulant, and clinical thromboses. This has been termed antiphospholipid antibody syndrome.

86235 (x 2)

Container/Tube: Red-top tube or gel-barrier tube

Sample Volume: 1 mL

Minimum Volume: 0.5 mL (Repeat testing is not possible with this specimen volume.)

Stability (collection to time of analysis/testing):

• Ambient: 14 days
• Refrigerated: 14 days
• Frozen: 14 days
• Freeze/Thaw Cycles: Stable (x 3)

This test aids in the diagnosis of Sjögren’s syndrome (especially with vasculitis) and lupus patients with Sjögren’s overlap syndrome. It includes the semiquantitative result of IgG class antibodies.

0.0 – 0.9 AI